In practical engineering, the choice of blade shape is crucial in the design process of turbine. It is because not only the structural stability but also the aerodynamic performance of turbine depends on the shape of blades. Generally, the design of blades is a typical multidisciplinary design optimization problem which includes many different disciplines. In this study, a fluid–structure coupling analysis approach is proposed to show the application of multidisciplinary design optimization in engineering. Furthermore, a strategy of uncertainty-based multidisciplinary design optimization using fluid–structure coupling analysis is proposed to enhance the reliability and safety of blades in turbine. The design of experiment technique is also introduced to construct response surface during uncertainty-based multidisciplinary design optimization using fluid–structure coupling analysis. The design solution shows that the adiabatic efficiency is increased and the equivalent stress is decreased, which means that better performance of the turbine can be obtained.