Local Application Research Articles

Joint Incentive Mechanism Design and Energy-Efficient Resource Allocation for Federated Learning in UAV-Assisted Internet of Vehicles

With the increasing demand for application development of task publishers (e.g., automobile enterprises) in the Internet of Vehicles (IoV), federated learning (FL) can be used to enable vehicle users (VUs) to conduct local application training without disclosing data. However, the challenges of VUs’ intermittent connectivity, low proactivity, and limited resources are inevitable issues in the process of FL. In this paper, we propose a UAV-assisted FL framework in the context of the IoV. An incentive stage and a training stage are involved in this framework. UAVs serve as central servers, which assist to incentivize VUs, manage VUs’ contributed resources, and provide model aggregation, making sure communication efficiency and mobility enhancement in FL. The numerical results show that, compared with the baseline algorithms, the proposed algorithm reduces energy consumption by 50.3% and improves model convergence speed by 30.6%.

Scaling from global to regional river flow with global hydrological models: Choice matters

High-resolution global flow discharge datasets are critical to understand the terrestrial water cycle and river ecosystem services. Recently, a number of global hydrological models have been developed to capture global river flow dynamics at locally relevant scales. However, the relative accuracy of these simulated flow discharges is largely unknown. In this paper, using the largest observed streamflow datasets from > 26,000 gauging stations, we evaluated the performance of monthly and sub-monthly flow variation (1980–2014) generated from five major global hydrological models, Catchment-based Macro-scale Floodplain model (CaMa-Flood), Global Flood Awareness System (GloFAS-reanalysis), Global Reach-level Flood Reanalysis (GRFR), PCRaster GLOBal Water Balance model (PCR-GLOBWB), and Water Global Assessment and Prognosis (WaterGAP). Significant spatial heterogeneity in model performance was identified. We found that estimates by all five discharge datasets have a relatively high correlation with the observations (medians > 0.6). But none of them showed adequate correlations between simulated and observed flows for systems in Southwest or Central U.S.A., South Africa, or South Australia. Across all models, overestimation of monthly mean flow was more common than underestimation and high flows at a sub-monthly scale were more accurately characterized than low flows. Performance of all models was poor in Africa and Oceania. No single model performed universally best at all gauging stations, but GRFR showed the best estimate at around 40 % of the locations. None of the models provided satisfying estimates for rivers and streams in arid regions. We also found a significant negative effect of flow regulation on the predictive accuracy of all models. Our study highlights the importance of thorough evaluation of global discharge datasets before their local and regional application and provides guidance for future enhancement of global hydrological models.

Nanometa Live: a user-friendly application for real-time metagenomic data analysis and pathogen identification.

Nanometa Live presents a user-friendly interface designed for real-time metagenomic data analysis and pathogen identification utilizing Oxford Nanopore Technologies' MinION and Flongle flow cells. It offers an efficient workflow and graphical interface for the visualization and interpretation of metagenomic data as it is being generated. Key features include automated BLAST validation, streamlined handling of custom Kraken2 databases, and a simplified graphical user interface for enhanced user experience. Nanometa Live is particularly notable for its capability to run without constant internet or server access once installed, setting it apart from similar tools. It provides a comprehensive view of taxonomic composition and facilitates the detection of user-defined pathogens or other species of interest, catering to both researchers and clinicians. Nanometa Live has been implemented as a local web application using the Dash framework with Snakemake handling the data processing. The source code is freely accessible on the GitHub repository at https://github.com/FOI-Bioinformatics/nanometa_live and it is easily installable using Bioconda. It includes containerization support via Docker and Singularity, ensuring ease of use, reproducibility, and portability.

A comparative study between local application of 10% zinc oxide to a combination of 10% zinc oxide and tocopherol in treating infant’s diaper dermatitis

Background Tocopherol is known to have an anti-inflammatory effect, thereby reducing erythema, edema, and skin irritation, which are the main pathologies observed in diaper dermatitis. Objective To compare the effect of local application of a combination of 10% zinc oxide and tocopherol in the treatment of infant diaper dermatitis with plain 10% zinc oxide. Methods A single-centric, prospective interventional study was conducted in a tertiary care hospital for 18 months where all children aged <1 year newly diagnosed with diaper dermatitis were selected. They were divided into two groups; one group received only 10% zinc oxide, while the other group received a combination of 10% zinc oxide and tocopherol for local application. Patients were assessed for rash dimensions, severity score of diaper dermatitis, and pH of the rash prior to starting treatment and at the end of 5 days. Statistical analysis was done using students paired two-tailed T-test. Results Out of 115 infants with diaper dermatitis, 88 were included in our study. The decrease in rash dimensions was greater in the study group (P=0.004). A mean diaper dermatitis severity score of 1.96±0.76 cm in the study group was noted on day five of the assessment (P<0.001). Conclusion The healing process in diaper dermatitis is accelerated when a combination of 10% zinc oxide and tocopherol is used. This study supports the evidence of expediting healing by tocopherol, which can be considered in treatment recommendations for diaper dermatitis.

Repeated local delivery of hyaluronic acid gel as adjunctive treatment of residual pockets in periodontitis patients undergoing supportive periodontal care. A randomized controlled clinical trial

ObjectivesTo assess the effect of hyaluronic acid (HyA) application as adjunct to re-instrumentation of residual pockets in patients undergoing regular supportive periodontal care (SPC).MethodsChronic periodontitis patients (stage III and IV, grade B and C) with 4 interproximal residual pockets were randomly assigned to the test (HyA gel) or control (saline) group. After subgingival instrumentation, test or control substance was applied subgingivally, then daily supragingivally for 3 months, and if required a second time after subgingival re-instrumentation after 3 months. Clinical and patient reported outcome parameters were recorded every 3 months for 12 months. Pocket closure [probing pocket depth (PPD) ≤ 4mm with absence of bleeding on probing (BoP) at PPD = 4mm] was the main outcome parameter.ResultsFifty-six patients (221 experimental sites) were analysed. Pocket closure was achieved in 56.8 and 46.6% of the experimental sites in the test and control group, respectively (p > 0.05), while median PPD and PPD distribution (< 5mm/5mm/ > 5mm) differed significantly between groups in favour of the test group, at 12 months. Further, significantly fewer sites in the HyA group required re-instrumentation at 3 months, and sites in the HyA group showed a tendency for lower odds to remain diseased compared to the control group (OR 0.48, 95%CI 0.22–1.06). The odds for a site to remain diseased after 12 months increased significantly in the presence of plaque (OR 7.94, 95%CI 4.12–15.28), but in general, decreased significantly over time (OR 0.48, 95%CI 0.28–0.81).ConclusionRe-instrumentation of residual pockets in SPC patients, per se, leads to a significant increase in pocket closure over time; this was impeded by poor plaque control. Repeated local application of HyA results in fewer sites requiring re-instrumentation and might slightly improve the rate of pocket closure. (clinicaltrials.gov registration nr. NCT04792541).Clinical relevanceHyA gel is easy to apply, well accepted by patients, and may have some positive effect in terms of fewer sites requiring re-instrumentation at 3 months and higher pocket closure rate at 12 months.

A Benchtop Round Window Model for Studying Magnetic Nanoparticle Transport to the Inner Ear.

The round window membrane (RWM) presents a significant barrier to the local application of therapeutics to the inner ear. We demonstrate a benchtop preclinical RWM model and evaluate superparamagnetic iron oxide nanoparticles (SPIONs) as vehicles for magnetically assisted drug delivery. Guinea pig RWM explants were inset into a 3D-printed dual chamber benchtop device. Custom-synthesized 7-nm iron core nanoparticles were modified with different polyethylene glycol chains to yield two sizes of SPIONs (NP-PEG600 and NP-PEG3000) and applied to the benchtop model with and without a magnetic field. Histologic analysis of the RWM was performed using transmission electron microscopy (TEM) and confocal microscopy. Over a 4-h period, 19.5 ± 1.9% of NP-PEG3000 and 14.6 ± 1.9% of NP-PEG600 were transported across the guinea pig RWM. The overall transport increased by 1.45× to 28.4 ± 5.8% and 21.0 ± 2.0%, respectively, when a magnetic field was applied. Paraformaldehyde fixation of the RWM decreased transport significantly (NP-PEG3000: 7.6 ± 1.5%; NP-PEG600: 7.0 ± 1.6%). Confocal and electron microscopy analysis demonstrated nanoparticle localization throughout all cellular layers and layer-specific transport characteristics within RWM. The guinea pig RWM explant benchtop model allows for targeted and practical investigations of transmembrane transport in the development of nanoparticle drug delivery vehicles. The presence of a magnetic field increases SPION delivery by 45%-50% in a nanoparticle size- and cellular layer-dependent manner. NA Laryngoscope, 134:3355-3362, 2024.

Hierarchical Composite Scaffold with Deferoxamine Delivery System to Promote Bone Regeneration via Optimizing Angiogenesis.

A bone defect refers to the loss of bone tissue caused by trauma or lesion. Bone defects result in high morbidity and deformity rates worldwide. Autologous bone grafting has been widely applied in clinics as the gold standard of treatment; however, it has limitations. Hence, bone tissue engineering has been proposed and developed as a novel therapeutic strategy for treating bone defects. Rapid and effective vascularization is essential for bone regeneration. In this study, a hierarchical composite scaffold with deferoxamine (DFO) delivery system, DFO@GMs-pDA/PCL-HNTs (DGPN), is developed, focusing on vascularized bone regeneration. The hierarchical structure of DGPN imitates the microstructure of natural bone and interacts with the local extracellular matrix, facilitating cell adhesion and proliferation. The addition of 1 wt% of halloysite nanotubes (HNTs) improves the material properties. Hydrophilic and functional groups conferred by polydopamine (pDA) modifications strengthen the scaffold bioactivity. Gelatin microspheres (GMs) protect the pharmacological activity of DFO, achieving local application and sustained release for 7 days. DFO effectively promotes angiogenesis by activating the signaling pathway of hypoxia inducible factor-1 α. In addition, DFO synergizes with HNTs to promote osteogenic differentiation and matrix mineralization. These results indicate that DGPN promotes bone regeneration and accelerates cranial defect healing.

An ensemble-based approach to estimate confidence of predicted protein-ligand binding affinity values.

When designing a machine learning-based scoring function, we access a limited number of protein-ligand complexes with experimentally determined binding affinity values, representing only a fraction of all possible protein-ligand complexes. Consequently, it is crucial to report a measure of confidence and quantify the uncertainty in the model's predictions during test time. Here, we adopt the conformal prediction technique to evaluate the confidence of a prediction for each member of the core set of the CASF 2016 benchmark. The conformal prediction technique requires a diverse ensemble of predictors for uncertainty estimation. To this end, we introduce ENS-Score as an ensemble predictor, which includes 30 models with different protein-ligand representation approaches and achieves Pearson's correlation of 0.842 on the core set of the CASF 2016 benchmark. Also, we comprehensively investigate the residual error of each data point to assess the normality behavior of the distribution of the residual errors and their correlation to the structural features of the ligands, such as hydrophobic interactions and halogen bonding. In the end, we provide a local host web application to facilitate the usage of ENS-Score. All codes to repeat results are provided at https://github.com/miladrayka/ENS_Score.

Idiopathic Subglottic Tracheal Stenosis

Idiopathic subglottic stenosis is a circular scarred narrowing of the airway at the transition from the cricoid cartilage to the trachea. The stenosis is found radiologically and endoscopically at the level of the cricoid cartilage without involvement of the cricoid or tracheal cartilage itself. The disease practically only affects women between the ages of 20 and 60. The same clinical picture occurs in granulomatosis with polyangiitis and less frequently in other autoimmune diseases, where it requires systemic treatment. The clinical picture usually begins insidiously with coughing and sputum production and leads to dyspnoea and a restricted cough. As the course is insidious and the patients are otherwise healthy, the symptoms are often misinterpreted and the diagnosis is delayed. Treatment consists of local measures, ranging from dilatation and laser surgical resection, sometimes with local application of medication to inhibit the proliferation of new scar tissue, to laryngotracheal resection of varying degrees. The disease is located in the border area between the trachea and larynx and the patients are therefore treated by ENT medicine, pneumology and thoracic surgery.

A multicentre, randomized, double blind, placebo controlled pilot study to evaluate the efficacy and safety of colloidal Nano silver gel (SilverSol) in the treatment of bacterial vaginosis, vulvovaginal candidiasis and trichomoniasis

The study evaluated the efficacy and safety of colloidal nano silver gel (SilverSol Vagigel) (A patented technology from American Biotech Labs, USA) in combination with 0.2% lactic acid in the female subjects for the treatment of vaginal infections.This study was a multicenter, randomized, double-blind, placebo-controlled pilot study in which post-menarchal female subjects between 18 and 65 years of age clinically diagnosed with bacterial vaginosis and vulvovaginal candidiasis were enrolled. The participants were randomized to receive treatment with SilverSol Vagigel or placebo (vehicle) gel (both treatments as one 4 gm application inserted into the vagina with an applicator device, once daily at bedtime for internal use and 2 gm gel for local application to the vulva and vagina for external use twice daily for a period of 14 days). The primary endpoint evaluated was the proportion of subjects achieving clinical cure. The secondary endpoint was the proportion of subjects achieving microbiological cure at the end of the study visit. A total of 57 subjects were randomized in the study out of which 38 subjects were randomized in SilverSol Vagigel arm and 19 subjects were randomized in placebo arm. SilverSol Vagigel significantly improved cure rates of vaginal infections compared to placebo. The proportion of subjects achieving clinical cure of vaginal infections was higher i.e., 33 (86.84%) subjects in SilverSol Vagigel arm compared to 07 (41.18%) subjects in Placebo gel arm (p-value: 0.0009). The clinical cure rate with SilverSol Vagigel was 81.82% (P=0.1758) for bacterial vaginosis and 92.59% (P=0.0010) for vulvovaginal candidiasis patients at the end of the study. Overall SilverSol Vagigel treatment resulted in a significantly higher microbial cure of vaginal infections (P=0.0028) compared to placebo, with a microbial cure rate of 100% for bacterial vaginosis (P=0.0330) and 85.19% for vulvovaginal candidiasis (P=0.0097). No adverse events were reported in subjects treated with SilverSol Vagigel.Colloidal Nano Silver Gel (SilverSol Vagigel) was effective and safe in treating bacterial vaginosis and vulvovaginal candidiasis.

The Monitoring System of Soil PH Factor Using IoT-Webserver-Android and Machine Learning: A Case Study

In Indonesia, the agriculture industry has been more reluctant than other sectors to adopt IoT, IT, and AI technology. Utilizing this technology will enable precision agriculture. This research aims to make and implement an IoT-Webserver-Android and Machine Learning-based soil PH factor monitoring tool system. The steps for making the tool system are divided into three subsystems. The first is a multiple sensors data acquisition subsystem, consisting of sensors for soil PH-Moisture, Temperature-Humidity, and Sunlight. The sensors are connected to the Arduino Uno microcontroller for serial communication with the ESP 8266 microcontroller for the Wi-Fi module. The second part is the monitoring subsystem with the local web application, which contains a MySQL database and a local web page. The third part is the monitoring subsystem with the Android application, which includes a real-time Firebase database and the application for real-time and mobile data display. The results have been implemented and display the expected outcomes. It is clear from the performance of the three subsystems. The outcomes of the tool system's data evaluation provide precise statistical values. Then, Machine Learning analysis generates accurate soil PH prediction models. It has been demonstrated that the monitoring system is applicable and has a favorable impact on data soil PH factor. The implication for the future is that this monitoring system should be added with Nitrogen-Phosphorus-Potassium sensors to measure soil nutrients. Also, the system added edge-analysis to be integrated in monitoring and analyzing soil nutrients.

Antimicrobial effects of clindamycin-loaded platelet-rich fibrin (PRF)

ObjectivesRecent research has demonstrated that platelet-rich fibrin (PRF) is an appropriate carrier for ampicillin/sulbactam. The aim of the study was to investigate whether PRF is also a suitable bio-carrier for clindamycin (CLI).MethodsPRF membranes were produced from 36 patients receiving intravenous therapy with CLI (e.g. due to the diagnosis of an osteonecrosis of the jaw or infections). Concentrations of CLI in PRF membranes were measured with liquid chromatography-tandem mass spectrometry, and the antimicrobial effects were investigated in vitro in agar diffusion tests with fresh PRF and PRF stored for 24 h. Storage was performed in an incubator at 36 °C to simulate the in-vivo situation.ResultsThe mean concentration of CLI in plasma was 1.0 ± 0.3 μg/100 mg plasma; in resulting PRF membranes 0.7 ± 0.4 μg/100 mg PRF. Agar diffusion tests were performed with Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus mitis, Porphyromonas gingivalis, and Fusobacterium nucleatum. Mean inhibition zones, in mm, for fresh PRF were 17.3, 12.2, 18.8, 17.1, 25.8 and 18.1, 12.7, 19.2, 17.3, and 26.3 for stored PRF, respectively.ConclusionThe results demonstrate that PRF is a suitable bio-carrier for CLI when administered systemically to patients. The concentration in PRF generated from patients after infusion of 600 mg CLI dose suffices to target clinically relevant bacteria.Clinical relevanceUsing PRF as a carrier for local antibiotic application can prevent infections in oral and maxillofacial surgery. Within the study limitations, the findings could expand the scope of PRF application by adding CLI as a new antibiotic to the spectrum of PRF therapy.

Understanding to Concept of Jarajanya Vyadhi (ageing related diseases) w.s.r. to Sandhigatavata (osteo arthritis)

As age advances Vata Dosha increases in an individual. This increasing Vata trigger and accelerates Dhatu Kshaya (depletion of tissues) and Bala Kshaya (diminished the body strength). Hence advancing age makes man prone to many diseases especially degenerative disorders. Asthis (bones) are the main seat of Vata Dosha and Sandhis (joints) is the main seat of Kapha Dosha. Vata Dosha is responsible for different body movements like Prasaarana and Akunchana of Sandhi (flexion and extension of joints), whereas Shleshaka Kapha located in Sandhi (joints) is provides nutrition, protection and to minimize the friction during the movement. Sandhigatavata is Vata pradhana vyadhi. It is quite similar to osteoarthritis, a degenerative joint disease stand in modern medical science. Sandhigatavata is Vata dominating disorder which result in inflammatory and degenerative changes in joints. Osteoarthritis is a disease of musculoskeletal system, affecting the joints mostly in elderly population and in weight bearing joints (particularly knee joint). The current standard modern medical pharmacological management of osteoarthritis includes the administration of analgesics and non-steroidal anti-inflammatory drugs (NSAIDs). However, their use neither provides adequate and significant relief in symptoms nor deceleration in disease process. Therefore, Vata shamaka aushadhis along with local application e.g. Abhyanga, different form of Swedana are beneficial. As Sandhigatavata is ageing related heath condition, Rasayana chikitsa can also be helpful in the management of Sandhigatavata (Osteoarthritis). This article enlighten the knowledge about Jarajanya vyadhi especially Sandhigatavata.

Efficacy of Virechana Karma along with Shamana Ausadha in Vipadika w.s.r to Palmar Psoriasis

Healthy skin depicts a healthy life. The skin is the largest organ and also a protecive covering for more delicate and funcionally sophisticated internal vicera. The skin was appreciated primarily as a passive barrier to fluid loss and mechanical injury. Many interrelated factors affects both the appearence and health of the skin including nutrition, hygiene, circulation, age, immunity, genetic traits, psychological state and drugs. Skin conditions can affect anyone- young and old, men and women. Acne vulgaries, psoriasis, eczema, urticaria etc are just a few examples of common skin disorders. Treating skin diseases is like, fighting war and if the warriors want to win, it is necessary to accurately access the strength of the adversary. So accurate diagnosis, application of principle, understanding the Avastha, treatment based on Avastha are highly essential. Vipadika is one of the types of the Kshudrakushta in Ayurveda. Here a 57 years old male patient history of repeted exposure to a chemical substance in paddy field with complain of excessive dryness, pain and fissures in palms since 1 year, diagnosed as Vipadika (palmer psoriasis) was treated with Sodhana (Virechana karma with Tivrit Avaleha) as well as Samana ausadhi with Trikatu churna, Mahatikta Ghrita, Khadiraarista, Panchatikta Ghrita guggul and Nimba taila (local application) having marked improvement. The study showed that combination of Ayurvedic modalities gives significant result in Lakshanas (symptoms) like Panisphutana (fissures in palms), Tivravedana (severe local pain), Daha (burning sensation), Kandu (itching) in a span of about 1 month.

Treatment of Second-Degree Scald Burn with the Application of Madhuchistadi Ghrita

Burn is one of the common conditions affected by individuals in day-to-day activity which needs extra attention to prevent ugly scars and many more complications. Ayurveda has a wide range of herbal formulations to manage such types of burn wounds. Among them, one is Madhuchistadi Ghrita which has burn wound healing properties by its Vrana Ropana drugs. A 45-year-old male patient suffered second-degree scald burn along with blisters and burning over the right hand for four days. The patient was successfully treated with a local application of Madhuchistadi Ghrita twice daily for 15 days. After seven days of treatment, the wound was 70% covered with epithelialization and at the end of 15 days, the wound was completely healed. During the follow-up period of 1 month, the skin was completely remodeled with the presence of skin appendages. This is a single case report with a positive outcome on the treatment of second-degree scald burns with the application of Madhuchistadi Ghrita.

α-Gal Nanoparticles in CNS Trauma: II. Immunomodulation FollowingSpinal Cord Injury (SCI) Improves Functional Outcomes.

Previous investigations have shown that local application of nanoparticles presenting the carbohydrate moiety galactose-α-1,3-galactose (α-gal epitopes) enhance wound healing by activating the complement system and recruiting pro-healing macrophages to the injury site. Our companion in vitro paper suggest α-gal epitopes can similarly recruit and polarize human microglia toward a pro-healing phenotype. In this continuation study, we investigate the in vivo implications of α-gal nanoparticle administration directly to the injured spinal cord. α-Gal knock-out (KO) mice subjected to spinal cord crush were injected either with saline (control) or with α-gal nanoparticles immediately following injury. Animals were assessed longitudinally with neurobehavioral and histological endpoints. Mice injected with α-gal nanoparticles showed increased recruitment of anti-inflammatory macrophages to the injection site in conjunction with increased production of anti-inflammatory markers and a reduction in apoptosis. Further, the treated group showed increased axonal infiltration into the lesion, a reduction in reactive astrocyte populations and increased angiogenesis. These results translated into improved sensorimotor metrics versus the control group. Application of α-gal nanoparticles after spinal cord injury (SCI) induces a pro-healing inflammatory response resulting in neuroprotection, improved axonal ingrowth into the lesion and enhanced sensorimotor recovery. The data shows α-gal nanoparticles may be a promising avenue for further study in CNS trauma.

Local Application of Acibenzolar-S-Methyl Treatment Induces Antiviral Responses in Distal Leaves of Arabidopsis thaliana.

Systemic acquired resistance (SAR) is a plant defense mechanism that provides protection against a broad spectrum of pathogens in distal tissues. Recent studies have revealed a concerted function of salicylic acid (SA) and N-hydroxypipecolic acid (NHP) in the establishment of SAR against bacterial pathogens, but it remains unknown whether NHP is also involved in SAR against viruses. We found that the local application of acibenzolar-S-methyl (ASM), a synthetic analog of SA, suppressed plantago asiatica mosaic virus (PlAMV) infection in the distal leaves of Arabidopsis thaliana. This suppression of infection in untreated distal leaves was observed at 1 day, but not at 3 days, after application. ASM application significantly increased the expression of SAR-related genes, including PR1, SID2, and ALD1 after 1 day of application. Viral suppression in distal leaves after local ASM application was not observed in the sid2-2 mutant, which is defective in isochorismate synthase 1 (ICS1), which is involved in salicylic acid synthesis; or in the fmo1 mutant, which is defective in the synthesis of NHP; or in the SA receptor npr1-1 mutant. Finally, we found that the local application of NHP suppressed PlAMV infection in the distal leaves. These results indicate that the local application of ASM induces antiviral SAR against PlAMV through a mechanism involving NHP.

Effect of human lactoferrin solution on histological changes of rabbit cornea in alkaline burns

BACKGROUND: Eye burns are a severe injury, accounting for 6.1–38.4% of all ophthalmic diseases. Alkaline burns are the most common and most severe forms of eye burns.&#x0D; AIM: Evaluation of the effectiveness of drug topical application based on human lactoferrin in alkaline cornea burns of the 3rd degree in the experiment.&#x0D; MATERIAL AND METHODS: The study was conducted on 42 rabbits. It included two groups: the first (without treatment) — alkaline burns during therapy with water for injection (1 drop 3 times a day) — 21 rabbits, the second (experimental) — treatment with lactoferrin solution (concentration 2.5 mg/ml, 1 drop 3 times a day) — 21 rabbits. Alkaline burns were induced by applying a filter paper disc moistened with 5% sodium hydroxide solution to the cornea. 6 eyes of 3 intact animals served as controls. The effectiveness of the drug was evaluated by the rate of closure of the corneal epithelium defect, the time of suppression of the inflammatory reaction in the area of the defect and the limbus, the degree of restoration of the morphological structure of the cornea, as close as possible to the normal rabbit cornea. The obtained data were processed using the methods of variation statistics, the Statistica 10.0 software package. The significance of differences was assessed by calculating the median and interquartile interval. The critical level of significance for statistical criteria was taken as p=0.05.&#x0D; RESULTS: From the 3rd day of the study, in the experimental treatment group, there was an acceleration of reepithelialization, restoration of the cornea's own substance, and a more rapid subsidence of inflammation compared to the control group. The thickness of the cornea in the center of the defect in the group without treatment was significantly higher than the values of intact animals at all periods of observation: on the 3rd day after the burn it was 615.99 [450.70–794.07] µm (p=0.000574), reached the maximum by day 7 — it was 1363.16 [907.78–1543.44] µm (p=0.000091), and by day 28 it decreased to 384.38 [376.03–398.14] µm (p=0.0000041). In the group with experimental treatment, the thickness of the cornea in the center of the defect also increased relative to intact animals, starting from the 1st day of pathology, reaching maximum values on the 3rd day — 436.70 [415.57–489.90] µm (p=0.005589). The use of lactoferrin solution in comparison with the first group led to a significant decrease in the thickness of the cornea in the center of the defect on 7th (p=0.039985) and 28th days (p=0.0443).&#x0D; CONCLUSION: Local application of lactoferrin solution in alkaline burns of the cornea promotes faster regeneration of the epithelium and restoration of the stroma structure of the rabbit cornea.

Evaluation of Damage Severity and Strength of Structural Member Using Macro‐Molecular PZT Sensor

AbstractThe structural health of various engineering systems has been easily monitored using macromolecular piezoelectric ceramic lead zirconate titanate (PZT) based electromechanical impedance (EMI) technique. It is in need to study the evaluation of various levels of damage and the present strength of structural systems to enhance the life of structures. Once damages occur, due to continuing usage they usually propagate in certain directions. Moreover, the increase in the severity of damages may lead to failure of the structural components or even the whole structure. Interaction between structure and PZT, which is found effective in EMI technique, is to identify effective damage detection. The macro‐molecular PZT's self‐actuating and sensing properties are utilized by the electromechanical impedance (EMI) method. The higher modes of vibration are locally activated by the local application of an AC source on the PZT transducers attached to the host structure. In this paper, the EMI technique using surface‐bonded PZT transducers is employed to obtain the structural health signature. The experiment is carried out on a real‐size concrete frame structure subjected to artificial damage to identify and locate the damages using frequency variations, and the severity is checked using extracted equivalent parameters; the damage index. This method also can identify hair‐like cracks at an early stage, which explains how it can shield the building from serious failures.

An improved axisymmetric interfacial lattice Boltzmann flux solver for large-density-ratio multiphase flows

In this paper, an improved axisymmetric interfacial lattice Boltzmann flux solver abandoning the previous predictor-corrector scheme is proposed. Unlike the previous model starting from the two-dimensional standard lattice Boltzmann method (LBM), the present method is developed using the axisymmetric LBM, which directly incorporates the axisymmetric effects into the distribution functions. As a result, the proposed solver does not need the corrector step involving complicated space derivatives. It makes this method simpler and more computationally efficient. In the present solver, the resultant governing equation is globally resolved by the finite volume method, while the fluxes are reconstructed by local application of the axisymmetric LBM. Therefore, the inconsistency between the local reconstruction and the global governing equation can be eliminated because the global equation can be strictly derived from the axisymmetric LBM, which holds stronger physical basis than the previous method. Numerical experiments about the interface capturing and the multiphase flows are conducted to test the proposed model. Results show that the present method is superior to the fractional step solver in terms of the accuracy, stability, and computational efficiency. In addition, this solver has the capacity of simulating large-density-ratio and complex interfacial change.