Students with learning difficulties, especially those who have trouble learning to read, write, and count often occur in low-grade inclusion primary school. Inclusion primary school teachers need skills and knowledge on inclusive education to help students learn to read, write, and count. Inclusive education is one of the educational approaches that can be applied in inclusion in primary schools that have students with diverse abilities, one of which is the learning disabilities of reading, writing, and counting. Efforts to optimize inclusive education can be made through interactive multimedia based on multisensory. Interactive multimedia based on multisensory is a learning medium that can accommodate various types of student learning by optimizing different senses owned by students, namely auditory, visual, kinesthetic, and tactile. There are two objectives in the application of interactive multimedia based on multisensory, i.e. (1) interactive multimedia based on multisensory forming student variously learning culture in the model of inclusive education; and (2) students can overcome the difficulties of learning to read, write, and count through the application of interactive multimedia based on multisensory.