In newly reclaimed coastal soil, saline conditions and nutrient deficiency are the restraining factors for crop yield. Manure and plastic film mulch are proved to play a vital role in reducing soil salt, increasing soil water, and improving soil nutrients and plant growth. A field experiment was carried out with plastic film mulch, manure, and their combinations in the Tiaozini reclamation area; four treatments were set up as (1) control treatment (CK), (2) plastic film mulch (PM), (3) farmyard manure (FM), and (4) combined application of plastic film mulch and farmyard manure (PM+FM). The main results showed that, compared with CK treatment, the average soil water content under the FM+PM treatment was increased by 5.8% and 3.6%, and the average soil salt content was reduced by 20.2% and 10.0% at 0–20 cm and 20–40 cm soil layers, respectively. This was because of the decrease in soil bulk density and increase in saturated hydraulic conductivity and saturated water content. Meanwhile, soil organic matter, total nitrogen, available nitrogen, and available phosphorus were significantly increased under the PM+FM treatment, except that for AN, which was significantly decreased at the 0–10 cm soil layer owing to plant uptake. Based on the decrease in soil salt, there was an improvement in soil hydraulic properties and soil nutrients, which resulted in summer maize biomass and yield being increased by 106% and 137%, respectively, and barley biomass and yield were increased by 133% and 106%, respectively, under FM+PM treatment. Consequently, combined manure and plastic film mulch application was better at reducing soil salt; increasing soil water content; and improving soil nutrients, plant growth, and yield production in newly reclaimed salt-affected soils.