A study of the seasonal development of the red-banded leaf roller, Argyrotaenia velutinana (Walker), on grapes in Erie County, Pennsylvania, indicated that the larvae of the first brood feed on the blossom buds, newly set berries, and leaves. The first-brood infestation was light and losses were usually not severe. The greatest damage was done by the second-brood larvae feeding in the cluster. The insect caused serious losses in 1960 and 1961. Field experiments were conducted, during 1952, 1960, and 1961 to determine the effectiveness of several insecticides for the control of the red-banded leaf roller. When applied against the first-brood larvae, parathion, lead arsenate, TDE, DDT, endrin, Diazinon ® ( O, O -diethyl O -(2-isopropyl-4-methyl-6-pyrimidinyl) phosphorothioate), Guthion® ( O, O -dimelhyl S -(4-oxo-1,2,3-benzotriazin-3-(4 H )-ylmethyl phosphorodithioate), and Sevin® (1-naphthyl N -methylcarbamate) were quite effective under conditions of light first-brood infestation. Against the second-brood larvae two applications of parathion, Guthion, or Sevin gave satisfactory control. A single application of parathion, Sevin, Diazinon, methoxychlor, EPN-300, malathion, TDE, or DDT did not give a high degree of control. One application of TDE, applied before blossoming against the first brood, did not give satisfactory control throughout the season.