Current Applications Research Articles

Accelerated thermal ageing on performance of polypropylene‐based semiconducting screen for high voltage direct current cable applications—Effect of antioxidants

AbstractThe potential of using eco‐friendly thermoplastic polypropylene (PP)‐based insulation for high voltage direct current (HVDC) cable has been widely investigated but much less work on the PP‐based semiconducting screen (SC). Considering a long service life (>30 years) under high temperature and high electrical stress is required for typical HVDC cables, and investigations on the effect of antioxidant (AO) concentration and thermal oxidative stability, mechanical, and electrical properties of PP‐based SCs have been conducted. It has been demonstrated that an appropriate combination and amounts of AOs are critical for achieving high thermal stability and maintaining the mechanical properties of SC after ageing in a harsh environment (150°C, with Cu, in air, 7 days). Although higher amounts of space charges have been observed in SC/PP/SC samples with higher AO concentrations, the impact on space charge behaviours is less after ageing, suggesting that ageing (or operating at high temperature) leads to microstructure evolution in SC and can potentially mitigate space accumulation in PP‐based insulating materials.

Two dimensional shear wave elastography—Basic principles and current applications

AbstractUltrasound‐based elastography techniques are increasingly available on modern ultrasound systems. The application of elastography extends the utility of ultrasound, yielding new information about the impact of disease on tissue biomechanics. By modifying the B‐mode imaging pulse, an Acoustic Radiation Force Impulse produces shear waves in selected tissue. Quantifying the speed of the resultant shear wave provides an indirect assessment of tissue stiffness, with stiffer tissue producing faster shear wave movement than softer tissue. Two main types of ultrasound shear wave elastography are currently in use. Point shear wave elastography uses one or two pulses to measure shear wave speeds over a small fixed area. Alternatively, two‐dimensional shear‐wave elastography provides a colour elastogram map over a larger area, allowing the operator to select specific regions of interest to measure shear wave speed. This article will discuss the essential physics principles, and clinical uses of two‐dimensional shear wave elastography, aiming to provide sonographers with a basic understanding of the technology and current applications.

O142: Current clinical applications and limitations of graft augmentation in rotator cuff repair: a systematic review

Abstract Background Rotator cuff tears (RCTs) are a leading source of chronic and acute shoulder pain globally, with causes spanning from tendon degeneration to traumatic injury. Especially prevalent in the aging population, RCTs have a significant retear rate despite surgical intervention, and recent years have seen an increase in the use of grafts in surgery to address many of the clinical issues previously encountered in tendon-healing. Objectives To compare the effectiveness of various grafts in graft-augmentation surgery for full-thickness rotator cuff tears, assessed with functional and clinical outcomes. Selection criteria Adult patients with MRI-diagnosed full-thickness RCT and subsequently underwent graft-augmentation surgery; followed-up >1year, with assessment for retear and quantitative clinical outcomes. Results 32 primary studies, mean follow-up of 2 years and total of 1052 patients were included. The effectiveness of graft-augmentation was assessed using retear rate, ASES, Constant, UCLA and VAS. Graft-augmentation significantly improves all functional and clinical scores (p<0.05), and decreases retear rate to an average of 18.5% >1year post-surgery (p<0.0001), with no significant difference in effectiveness between the 4 different types of grafts. (p>0.05). No significant difference in outcomes was found in graft-augmentation between different tear sizes. Conclusions Graft augmentation for RCTs shows significant improvements in clinical and functional outcomes, and significantly lowers retear rate compared to conservative treatment or surgery without graft augmentation. The choice of graft has been shown to be of less importance than the clinical decision to use surgical-intervention with graft-augmentation, which applies to full-thickness tears of all sizes; both primary and revision tears.

Materials and Strategies to Enhance Melt Electrowriting Potential.

Melt electrowriting (MEW) is an emerging additive manufacturing (AM) technology that enables the precise deposition of continuous polymeric microfibers, allowing for the creation of high-resolution constructs. In recent years, MEW has undergone a revolution, with the introduction of active properties or additional functionalities through novel polymer processing strategies, the incorporation of functional fillers, postprocessing, or the combination with other techniques. While extensively explored in biomedical applications, MEW's potential in other fields remains untapped. Thus, this review explores MEW's characteristics from a materials science perspective, emphasizing the diverse range of materials and composites processed by this technique and their current and potential applications. Additionally, the prospects offered by postprinting processing techniques are explored, together with the synergy achieved by combining melt electrowriting with other manufacturing methods. By highlighting the untapped potentials of MEW, this review aims to inspire research groups across various fields to leverage this technology for innovative endeavors.

Current developments and future perspectives of nanotechnology in orthopedic implants: an updated review.

Orthopedic implants are the most commonly used fracture fixation devices for facilitating the growth and development of incipient bone and treating bone diseases and defects. However, most orthopedic implants suffer from various drawbacks and complications, including bacterial adhesion, poor cell proliferation, and limited resistance to corrosion. One of the major drawbacks of currently available orthopedic implants is their inadequate osseointegration at the tissue-implant interface. This leads to loosening as a result of immunological rejection, wear debris formation, low mechanical fixation, and implant-related infections. Nanotechnology holds the promise to offer a wide range of innovative technologies for use in translational orthopedic research. Nanomaterials have great potential for use in orthopedic applications due to their exceptional tribological qualities, high resistance to wear and tear, ability to maintain drug release, capacity for osseointegration, and capability to regenerate tissue. Furthermore, nanostructured materials possess the ability to mimic the features and hierarchical structure of native bones. They facilitate cell proliferation, decrease the rate of infection, and prevent biofilm formation, among other diverse functions. The emergence of nanostructured polymers, metals, ceramics, and carbon materials has enabled novel approaches in orthopaedic research. This review provides a concise overview of nanotechnology-based biomaterials utilized in orthopedics, encompassing metallic and nonmetallic nanomaterials. A further overview is provided regarding the biomedical applications of nanotechnology-based biomaterials, including their application in orthopedics for drug delivery systems and bone tissue engineering to facilitate scaffold preparation, surface modification of implantable materials to improve their osteointegration properties, and treatment of musculoskeletal infections. Hence, this review article offers a contemporary overview of the current applications of nanotechnology in orthopedic implants and bone tissue engineering, as well as its prospective future applications.

Light on Alzheimer's disease: from basic insights to preclinical studies.

Alzheimer's disease (AD), referring to a gradual deterioration in cognitive function, including memory loss and impaired thinking skills, has emerged as a substantial worldwide challenge with profound social and economic implications. As the prevalence of AD continues to rise and the population ages, there is an imperative demand for innovative imaging techniques to help improve our understanding of these complex conditions. Photoacoustic (PA) imaging forms a hybrid imaging modality by integrating the high-contrast of optical imaging and deep-penetration of ultrasound imaging. PA imaging enables the visualization and characterization of tissue structures and multifunctional information at high resolution and, has demonstrated promising preliminary results in the study and diagnosis of AD. This review endeavors to offer a thorough overview of the current applications and potential of PA imaging on AD diagnosis and treatment. Firstly, the structural, functional, molecular parameter changes associated with AD-related brain imaging captured by PA imaging will be summarized, shaping the diagnostic standpoint of this review. Then, the therapeutic methods aimed at AD is discussed further. Lastly, the potential solutions and clinical applications to expand the extent of PA imaging into deeper AD scenarios is proposed. While certain aspects might not be fully covered, this mini-review provides valuable insights into AD diagnosis and treatment through the utilization of innovative tissue photothermal effects. We hope that it will spark further exploration in this field, fostering improved and earlier theranostics for AD.

Harnessing the Power of Stimuli-Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System.

The quest for effective and reliable methods of delivering medications, with the aim of improving delivery of therapeutic agent to the intended location, has presented a demanding yet captivating field in biomedical research. The concept of smart drug delivery systems is an evolving therapeutic approach, serving as a model for directing drugs to specific targets or sites. These systems have been developed to specifically target and regulate the administration of therapeutic substances in a diverse array of chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel diseases, rheumatoid arthritis, and different cancers. Nevertheless, numerous comprehensive clinical trials are still required to ascertain both the immediate and enduring impacts of such nanosystems on human subjects. This review delves into the benefits of different drug delivery vehicles, aiming to enhance comprehension of their applicability in addressing present medical requirements. Additionally, it touches upon the current applications of these stimuli-reactive nanosystems in biomedicine and outlines future development prospects.

INTEGRATING IOT IN PEDIATRIC HEALTHCARE: A SYSTEMATIC REVIEW OF CURRENT APPLICATIONS AND FUTURE DIRECTIONS FOR PANCREATIC DISEASES AND OBESITY Tolulope O. Olorunsogo1

In recent years, the integration of Internet of Things (IoT) technologies into healthcare systems has shown immense promise in revolutionizing patient care, particularly in pediatric populations. This systematic review aims to explore the current landscape of IoT applications in pediatric healthcare, specifically focusing on pancreatic diseases and obesity, two significant health challenges affecting children worldwide. The review comprehensively analyzes existing literature, including peer-reviewed articles, conference papers, and relevant reports. By employing systematic search strategies across various databases, studies were identified, screened, and synthesized to elucidate the diverse applications of IoT in managing pancreatic diseases and obesity among pediatric patients. The findings reveal a multitude of IoT applications tailored to pediatric healthcare, ranging from wearable devices for continuous glucose monitoring in diabetic children to smart scales and activity trackers for managing pediatric obesity. These technologies offer real-time monitoring, data analytics, and personalized interventions, enhancing disease management, improving patient outcomes, and promoting patient engagement and adherence to treatment regimens. Furthermore, this review identifies critical challenges and limitations associated with current IoT implementations in pediatric healthcare, such as data privacy concerns, interoperability issues, and the need for robust regulatory frameworks. Addressing these challenges is crucial to maximizing the potential benefits of IoT in pediatric healthcare and ensuring its safe and effective integration into clinical practice. The review outlines promising future directions for IoT in managing pancreatic diseases and obesity in pediatric populations. These include integrating advanced sensors and artificial intelligence algorithms for predictive analytics, developing user-friendly and child-centric IoT solutions, and establishing collaborative networks for data sharing and knowledge exchange. This systematic review underscores the transformative impact of IoT technologies in pediatric healthcare, particularly in managing pancreatic diseases and obesity. By highlighting current applications and future directions, this study provides valuable insights for clinicians, researchers, and policymakers to harness the full potential of IoT in improving pediatric health outcomes.
 Keywords: IoT, Healthcare, Pancreatic, Disease, Obesity, Pediatric, Review.

Application of direct electric current to the corneal and conjunctival epithelia regulates the tight junctional assembly for ocular iontophoretic drug delivery

Objectives: In this study, we determined how iontophoresis (IP) affects tight junctions (TJs) in isolated rabbit corneas and conjunctiva.
 Methods: Direct electric current in the range of 0.5–2.0 and 0.5–10 mA/cm2 were applied to the cornea and conjunctiva, respectively, for 30 min. The localization and expression levels of TJ-associated proteins were assessed before and after the application of the electric currents using immunostaining and western blotting.
 Results: In both corneal and conjunctival epithelia, the localization of proteins, such as claudin-1, claudin-4, occludin, and ZO-1, was temporarily altered by anodal and cathodal IP; however, the protein relocalization was slower at higher currents. Additionally, in both anodal and cathodal IP, the expression levels of claudin-1 and occludin in the cornea and conjunctiva remained unchanged after the application of the electric currents compared with those before.
 Conclusion: Our results indicated that the application of a direct electric current temporarily regulated TJ assemblies without altering the levels of TJ-associated proteins in both the cornea and conjunctiva. This temporary weakening of the paracellular barrier by the current may be responsible for the enhanced drug transport across the cornea and conjunctiva induced by ocular IP.
 Keywords: ocular drug delivery, iontophoresis, electric current, cornea, conjunctiva, tight junction

Updates in pelvic neuromodulation: the role of pelvic neuromodulation in pelvic disorders

Pelvic disorders affecting both male and female patients are major areas of concern for clinicians in cases where pharmacotherapy and behavioral therapy are not effective. In such cases, pelvic neuromodulation has become an alternative therapy that could relieve chronic pelvic pain and enhance the quality of life. The goal of this paper was to present a summary of the current therapeutic applications of various pelvic neuromodulation techniques and their efficacy in treating patients with a range of pelvic illnesses. Based on the available literature, this review assessed the validity and significance of the last 10 years’ advancements in the fields of sacral neuromodulation (SNM), posterior tibial nerve stimulation (PTNS), and pudendal neuromodulation (PNM), including meta-analyses, randomized controlled trials, and observational, prospective, and retrospective studies.

Palliative Care in Sub-Saharan Africa: A Narrative Review.

Background: As a person nears the end of their life, culture and ethnicity increasingly drive preferences and priorities for care. Understanding these preferences and priorities is fundamental to health care professionals' goals to respect decision making and support the individual throughout this phase of life. Across Africa, several countries are in the initial stages of implementing palliative care services in their burgeoning health care systems. Moving forward, it is imperative to consider cultural similarities and differences when compared with the Western world, where the field of palliative care evolved, to create a tailored palliative care approach that is consistent with African culture. In palliative care, understanding cultural preferences and priorities requires communication between the patient and the provider and is a crucial step toward a successful implementation in Africa. A paternalistic patient-provider relationship is the current leading model in sub-Saharan Africa.1 Aim: This narrative review explores the prevalence of paternalism and explores its appropriateness and necessity in the current application of palliative care in sub-Saharan African countries. Methods: This narrative review was conducted using four databases as well as hand searching of relevant articles sourced from references of already selected articles. A total of 730 articles were identified. Fourteen articles met the inclusion/exclusion criteria set for this narrative review. Results: In sub-Saharan Africa, the leading patient-provider relationship was determined to be paternalistic. Reasons for this were language, education, cultural norms and expectations, lack of time, and benevolence. Conclusions: The implementation of palliative care often relies on communication of patient desires and goals. Consideration is needed to determine how a provider can appropriately know these factors in a paternalistic relationship.

Public Health Law In Malaysia And The United States: Comparing Current Applications

Background: The main objective of public health law is to pursue the highest possible level of physical and mental health in the population, consistent with the values of social justice. Aims: To elaborate on Malaysia’s public health laws that share unique commonalities with those of the United States of America, due to both countries’ colonial past as part of the British Empire. Methods: Historical review and analysis of current public health law issues in both nations. Results: The United States of America gained full independence from the British Empire on 3 September 1783, while almost three years later, on 11 August 1786, the Union Jack was raised on the island of Pulau Pinang in Malaysia. When the colonies first formed the United States, there was no national public health law; the American colonies adopted the English laws on the control of diseases. This is similar to Pulau Pinang, after the implementation of the Charter of Justice in 1807. Conclusion: Current applications of the law, which include quarantine, sanitation, disease reporting, and vaccination,exhibit interesting similarities as well as differences between the United States and Malaysia.

Maximizing the role of undergraduate teaching assistants (UTAs) to match signature pedagogies in leadership education

PurposeThe purpose of the current application paper is to integrate previous literature with recent results from practitioners on effective practices for utilizing small groups in the leadership classroom.Design/methodology/approachWe use these integrated findings to innovate practice on maximizing the role of undergraduate teaching assistants (UTAs) by matching their tasks to signature pedagogies in leadership education.FindingsThe integrated findings revealed three practice themes: (1) match UTAs to pedagogical approach, (2) create small groups by design and (3) providing training and reflection practice for UTAs.Originality/valueIn sum, leadership education can and should challenge historical practices in higher education whereby UTAs are used purely for grading and course logistics management.

Digital Twins along the product lifecycle: A systematic literature review of applications in manufacturing

Background The evolution of product expectations in the era of mass personalization implies an improvement and a better control of individualized creation and production processes throughout the product lifecycle. The application of the digital twin seems to be a favoured solution in this context, but its study during the lifecycle of a product has only been partially evoked in the literature. Methods The purpose of this research is to identify the leverages and barriers to support the digital twin diffusion in the manufacturing industry from a technological, operational, and social standpoint. To determine these elements, this paper will identify current digital twins applications in the literature under two main dimensions: the type of digital twin, and its applications along the product lifecycle. To achieve this analysis a systematic literature review was carried out. The publications selection was based on the presence in these of a case of application of a digital twin with a focus in the Manufacturing sector. Within this review, 188 scientific papers were comprehensively compiled and analyzed. Results Results showed that although the term digital twin is widely used, the deployment of digital twin technologies in manufacturing is still at an early stage as most of the reported digital twin applications were in fact prototypes focused on the real-time observability of the physical system, either for optimization or predictive maintenance. Moreover, regarding the product lifecycle, most of the applications have been focused on the production and operational phases whereas those at the design and disposal phases are still limited. Conclusions This paper presents an original approach to the study of digital twins, focusing simultaneously on the type of digital twin, the application area and the lifecycle phase. Under the basis of the obtained results, future perspectives on the use of digital twins along the lifecycle are proposed.

Phospholipid Membranes as Chemically and Functionally Tunable Materials.

The sheet-like lipid bilayer is the fundamental structural component of all cell membranes. Its building blocks are phospholipids and cholesterol. Their amphiphilic structure spontaneously leads to the formation of a bilayer in aqueous environment. Lipids are not just structural elements. Individual lipid species, the lipid membrane structure, and lipid dynamics influence and regulate membrane protein function. An exciting field is emerging where the membrane-associated material properties of different bilayer systems are used in designing innovative solutions for widespread applications across various fields, such as the food industry, cosmetics, nano- and biomedicine, drug storage and delivery, biotechnology, nano- and biosensors, and computing. Here, the authors summarize what is known about how lipids determine the properties and functions of biological membranes and how this has been or can be translated into innovative applications. Based on recent progress in the understanding of membrane structure, dynamics, and physical properties, a perspective is provided on how membrane-controlled regulation of protein functions can extend current applications and even offer new applications.

Plastic Pollution in Agriculture as a Threat to Food Security, the Ecosystem, and the Environment: An Overview

Plastic products in plant production and protection help farmers increase crop production, enhance food quality, and reduce global water use and their environmental footprint. Simultaneously, plastic has emerged as a critical ecological issue in recent years, and its pollution has significantly impacted soil, water, and plants. Thus, this review examines the multifaceted problems of plastic pollution in agriculture as a risk to food security, the ecosystem, and the environment. The study’s objective was to review and present the most recent information on using different plastic products in agriculture, the sources of plastic pollution, the advantages and drawbacks of using plastic products, and the strategies for mitigating plastic pollution in agriculture. Furthermore, after examining current plastic applications, benefits, adverse effects, and risks to soil, plants, and the environment, we addressed the requirements for technological advancements, regulations, and social processes that could contribute to mitigating plastic pollution in our ecosystems. We identified different pathways toward more sustainable use of plastics in agriculture and discussed future research directions.

A systematic review of transcranial magnetic and direct current stimulation application on the improvement of reading ability of developmental dyslexia

Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), two non-invasive brain stimulation techniques (NIBS), are modulatory tools to probe into a possible causal and interaction relationship between brain structure and function. Developmental dyslexia (DD) is a neurodevelopmental disorder, which is characterized by significant and persistent difficulty in learning and reading-related skills. Previous studies have shown that TMS and tDCS play an important role in reading ability and neurocognitive plasticity, such as visuospatial working memory, attention, speech recognition, and motor perception. However, research on the effectiveness of TMS/tDCS in treating DD is still limited. The current study aimed to systematically review the broadly application of TMS/tDCS in the treatment of dyslexic children and adolescents as well as adults. Twelve studies involving 128 dyslexic subjects (199 children/adolescents and 29 adults) were included in this systematic review. Overall, TMS/tDCS appeared to be an effective technique for treating dyslexia. However, further future studies with larger sample sizes as well as more different languages are essential to demonstrate its potential for successful intervention in DD. This systematic review suggested that the combination of tDCS and cognitive training was effective. Moreover, the treatment with multiple sessions and coupled with behavioral training appeared to result in greater efficacy than stand-alone NIBS treatment.

Research Progress of Ozone/Peroxymonosulfate Advanced Oxidation Technology for Degrading Antibiotics in Drinking Water and Wastewater Effluent: A Review.

Nowadays, antibiotics are widely used, increasing the risk of contamination of the water body and further threatening human health. The traditional water treatment process is less efficient in degrading antibiotics, and the advanced oxidation process (AOPs) is cleaner and more efficient than the traditional biochemical degradation process. The combined ozone/peroxymonosulfate (PMS) advanced oxidation process (O3/PMS) based on sulfate radical (SO4•-) and hydroxyl radical (•OH) has developed rapidly in recent years. The O3/PMS process has become one of the most effective ways to treat antibiotic wastewater. The reaction mechanism of O3/PMS was reviewed in this paper, and the research and application progress of the O3/PMS process in the degradation of antibiotics in drinking water and wastewater effluent were evaluated. The operation characteristics and current application range of the process were summarized, which has a certain reference value for further research on O3/PMS process.

Design and implementation of breast cancer prediction system based on machine learning

With the increasing incidence of breast cancer worldwide, early diagnosis and treatment of breast cancer has become the key to improving patient survival and quality of life. As a powerful data analysis tool, machine learning is increasingly widely used in the medical field, especially in disease prediction and assisted diagnosis. This paper aims to design and implement a machine learning-based breast cancer prediction system to improve the early diagnosis rate of breast cancer and reduce medical costs. Through an in-depth analysis of the global incidence of breast cancer and the current application of machine learning in the medical field, this study clarified the importance of breast cancer prediction and the problems existing in the existing prediction system. This paper further discusses the theoretical basis of machine learning in breast cancer detection, evaluates the advantages and disadvantages of commonly used machine learning algorithms, and reviews the latest research progress in this field at home and abroad. In the part of system design and implementation, the architecture design, data flow and processing process of the prediction system, as well as the method of data preprocessing and feature selection are introduced in detail. In addition, this paper also constructs a machine learning model suitable for breast cancer prediction, and carries out systematic implementation and testing through the actual development environment. In the discussion section, the applicability of machine learning model in breast cancer prediction is analyzed, the causes of model inefficiency are discussed, and the corresponding solutions are proposed. Finally, the paper summarizes the content of the full text, points out the limitations of the research, and puts forward the direction of future research. The results of this study not only provide a new technical means for the early diagnosis of breast cancer, but also provide valuable experience for the application of machine learning in the medical field.

Current and future applications of light-sheet imaging for identifying molecular and developmental processes in autism spectrum disorders.

Autism spectrum disorder (ASD) is identified by a set of neurodevelopmental divergences that typically affect the social communication domain. ASD is also characterized by heterogeneous cognitive impairments and is associated with cooccurring physical and medical conditions. As behaviors emerge as the brain matures, it is particularly essential to identify any gaps in neurodevelopmental trajectories during early perinatal life. Here, we introduce the potential of light-sheet imaging for studying developmental biology and cross-scale interactions among genetic, cellular, molecular and macroscale levels of circuitry and connectivity. We first report the core principles of light-sheet imaging and the recent progress in studying brain development in preclinical animal models and human organoids. We also present studies using light-sheet imaging to understand the development and function of other organs, such as the skin and gastrointestinal tract. We also provide information on the potential of light-sheet imaging in preclinical drug development. Finally, we speculate on the translational benefits of light-sheet imaging for studying individual brain-body interactions in advancing ASD research and creating personalized interventions.