Cold Application Research Articles

Neuropathy in pruritus medicine : Recommended diagnostics and therapy

Chronic itch is afrequent and debilitating condition that greatly affects the quality of life of those affected. In asubset of patients, damage to the peripheral or central nervous system constitutes the cause of the itch. Small-fiber neuropathy, nerve compression syndromes, post-herpetic neuralgia, scars and burns are possible conditions affecting the peripheral nervous system potentially causing itch, whereas space-occupying lesions affecting the spinal cord and stroke are examples of conditions that may induce central itch. Neuropathic itch starts on normal appearing skin, is often accompanied by pain sensations and other dysesthesias, and usually relieved by local cold application. Its distribution depends on the affected site of the somatosensory system. Acomprehensive medical history is paramount to reach the diagnosis, while complementary diagnostics with skin biopsies for the investigation of cutaneous neuromorphological alterations or medical imaging to rule out nerve impingement may be advised in selected cases. Topical agents such as capsaicin or local anesthetics as well as systemic drugs such as gabapentinoids, antidepressants and opioid receptor modulators are used in the treatment of neuropathic itch. This review article provides an overview of the clinical features, underlying causes, diagnostic workup and therapeutic approach in neuropathic itch.

Training in the use of the water jet and cold atmospheric plasma jet for the decontamination of dental implants

ObjectivesClinical trials testing new devices require prior training on dummies to minimize the "learning curve" for patients. Dentists were trained using a novel water jet device for mechanical cleaning of dental implants and with a novel cold plasma device for surface functionalisation during a simulated open flap peri-implantitis therapy. The hypothesis was that there would be a learning curve for both devices.Materials and methods11 dentists instrumented 44 implants in a dummy-fixed jaw model. The effect of the water jet treatment was assessed as stain removal and the effect of cold plasma treatment as surface wettability. Both results were analysed using photographs. To improve treatment skills, each dentist treated four implants and checked the results immediately after the treatment as feedback.ResultsWater jet treatment significantly improved from the first to the second implant from 62.7% to 75.3% stain removal, with no further improvement up to the fourth implant. The wettability with cold plasma application reached immediately a high level at the first implant and was unchanged to the 4th implant (mean scores 2.7 out of 3).ConclusionA moderate learning curve was found for handling of the water jet but none for handling of the cold plasma.Clinical relevanceScientific rational for study: Two new devices were developed for peri-implantitis treatment (Dental water jet, cold plasma). Dentists were trained in the use of these devices prior to the trial to minimize learning effects.Principal findings: Experienced dentists learn the handling of the water jet very rapidly and for cold plasma they do not need much training.Practical implications: A clinical study is in process. When the planned clinical study will be finished, we will find out, if this dummy head exercise really minimised the learning curve for these devices.

High-density thermal sensitivity maps of the body of people with multiple sclerosis: Implications for inclusive personal comfort systems

Inclusive thermal comfort solutions should accommodate the need of clinical groups such as people with Multiple Sclerosis (pwMS), who experience abnormal thermal sensitivity. The aim of this study was to develop high-density body maps of temperature sensitivity in pwMS to inform the design of patient-centred personal comfort systems.Fourteen pwMS (6 M/8 F; 48.6 ± 10.0 y) and 13 healthy individuals (CTR; 5 M/8 F; 47.8 ± 10.4) underwent a quantitative sensory test in a thermoneutral environment, during which they rated their local thermal sensations arising from the application of warm (39°C) and cold (27°C) stimuli to 115 bilateral body sites across the face, torso, upper and lower limbs. We used a z-transformation to create maps of hypo- and hyper-sensitivity for each individual MS participant using normative CTR data.We found that 50% of pwMS (N = 7/14) presented a loss of cold sensitivity over the upper limb, and a loss of warm sensitivity over the feet. Furthermore, 36% of pwMS (N = 5) presented warm hyper-sensitivity over the upper limb. Finally, cold sensitivity loss and warm sensitivity gain were more evenly distributed and affected a greater proportion of skin sites in MS (i.e. cold hypo-sensitivity = 44% of tested sites; warm hyper-sensitivity = 14%) than warm sensitivity loss (i.e. 10%), which was more focused on sites such as the feet.Our findings highlight the need to consider “thermosensory corrective power” when designing personal comfort systems, to accommodate either thermosensory loss or gain in pwMS. Our approach to clinical body mapping may support this process and help meeting the unique thermal needs of vulnerable individuals.

Effects of cold spray on thirst, frequency of oral care, and pain of general surgery intensive care unit patients

This study aims to investigate the effects of intraoral cold water spray on thirst, frequency of oral care and postoperative period pain at surgical incision site in patients having abdominal surgery. The study was carried out as a randomized controlled trial, registered under Clinical Trial Number: NCT05940818. The study involved 110 participants, divided equally into two groups (n = 55): the experimental group and the control group. Data were collected using patient information form, NRS, Intensive Care Oral Care Frequency Assessment Scale (ICOCFAS) and Visual Analog Scale (VAS). The severity of thirst at 1st, 8th, 16th h of post-operative period (p < 0.01) and the frequency of oral care application at 16th h were statistically significantly decreased in the experimental group when compared to the control group (p < 0.01).There wasn’t statistically significant difference between the patients in the experimental and control groups in terms of pain at surgical incision site (p > 0.05). The patient’s thirst and need for frequent oral care in the postoperative period were reduced by the application of a cold water spray. In patients undergoing abdominal surgery, the use of cold water spray application may be recommended to reduce thirst and the need for frequency of oral care application.

A STUDY TO ASSESS THE EFFECT OF CRYOTHERAPY ON PAIN AND SELECTED BIOPHYSIOLOGICAL PARAMETERS DURING ARTERIOVENOUS FISTULA CANNULATION AMONG PATIENTS ON MAINTENANCE HAEMODIALYSIS

The current study entitled a study to assess the effect of Cryotherapy on pain and selected Biophysiological parameters during arteriovenous fistula cannulation among patients on maintenance Hemodialysis at KMCH, Coimbatore was undertaken, during the year 2010 - 2011 in partial fulfillment of the requirement for the degree of Master of Science in Nursing at KMCH College of Nursing, Coimbatore which is affiliated to Dr. M.G.R. Medical University, Chennai. Objectives: To assess the pain intensity during Xylocaine infiltration. To determine the effect of Cryotherapy on pain and Biophysiological parameters during AV fistula cannulation. To associate the level of pain with selected demographic variables. Design: Repeated Measures design. Setting: Hemodialysis unit of Kovai Medical Center and Hospital, Coimbatore. Sample: Sample size was 50. Conceptual framework: Modified Orlando‟s Nursing process model. Outcome measures: The demographic data was collected from the subjects. The pain intensity was measured during cannulation with Xylocaine and with Cryotherapy using Numerical Pain rating Scale. The investigator recorded the Biophysiological parameters during the procedure. Intervention: Cold application was done prior and during cannulation over on the web between the thumb and index finger of the hand which does not have the AV fistula. Results: The mean pain score with Xylocaine infiltration at arterial site was 4.81 and at the venous site was 4.86.There was a significant reduction in the pain score during cannulation with the application of Cryotherapy. The mean pain score during cannulation after Xylocaine at the arterial site was 1.59 and at the venous site was 1.51 whereas the mean pain score during cannulation after Cryotherapy was 0.96 and 0.92 correspondingly. But there was no statistically significant difference between the values of Biophysiological parameters such as BP, PR and RR during cannulation done with Xylocaine and with Cryotherapy. There was no significant association between pain score and age and gender of the subjects but there was significant association between pain and duration of illness and duration of treatment Conclusion: Cryotherapy is an effective nonpharmacological measure in reducing pain during AV fistula cannulation among Hemodialysis patients.

4E assessment of ejector-enhanced R290 heat pump cycle with a sub-cooler for cold region applications

Currently, the worldwide implementation of the Montreal Protocol has accelerated the development of low GWP refrigerants. R290 as an alternative refrigerant with low GWP has great advantages over R134a for heat pump applications. However, the use of expansion valve throttling in the heat pump cycle has a large irreversible loss. Therefore, an ejector-enhanced sub-cooler vapor injection heat pump cycle (ESVIC) with R290 for water heating is proposed in this paper to improve the energy efficiency by applying ejector. The thermodynamic models are established based on the 4E (energy, exergy, economic and environmental) analysis to compare its performance with the basic ejector-enhanced heat pump cycle (BEEC) and the sub-cooler vapor injection heat pump cycle (SVIC). The energy analysis results show that compared with the BEEC and SVIC, the volumetric heating capacity of the ESVIC is improved by 42.0 % and 21.2 %, and the heating coefficient of performance (COPh) of the ESVIC is improved by 27.6 % and 5.3 %, respectively. The exergy analysis results indicate that in BEEC, SVIC and ESVIC the exergy destruction of the expansion valves is 0.3 %, 13.5 % and 0.8 %, respectively. It is indicated that the adoption of ejector can significantly decrease the exergy destruction of expansion valves. Moreover, the environmental analysis results reveal that the carbon emissions of ESVIC is 21.5 % and 5.0 % lower than those of BEEC and SVIC, respectively. Besides, for the ESVIC system, the carbon emissions of the life cycle climate performance when using R290 are 9.9 % lower than that of using R134a, indicating that the R290 is a potential substitute for R134a in heat pump applications. The economic analysis results demonstrate that the unit exergy production costs of ESVIC is 21.6 % and 5.1 % lower than BEEC and SVIC, respectively.

Performing of the Winter Buds and Phloem Tissue in Grape Cultivars After Cold Applications

Performing of the Winter Buds and Phloem Tissue in Grape Cultivars After Cold Applications

Cold-active microbial enzymes and their biotechnological applications.

Microorganisms known as psychrophiles/psychrotrophs, which survive in cold climates, constitute majority of the biosphere on Earth. Their capability to produce cold-active enzymes along with other distinguishing characteristics allows them to survive in the cold environments. Due to the relative ease of large-scale production compared to enzymes from plants and animals, commercial uses of microbial enzyme are alluring. The ocean depths, polar, and alpine regions, which make up over 85% of the planet, are inhabited to cold ecosystems. Microbes living in these regions are important for their metabolic contribution to the ecosphere as well as for their enzymes, which may have potential industrial applications. Cold-adapted microorganisms are a possible source of cold-active enzymes that have high catalytic efficacy at low and moderate temperatures at which homologous mesophilic enzymes are not active. Cold-active enzymes can be used in a variety of biotechnological processes, including food processing, additives in the detergent and food industries, textile industry, waste-water treatment, biopulping, environmental bioremediation in cold climates, biotransformation, and molecular biology applications with great potential for energy savings. Genetically manipulated strains that are suitable for producing a particular cold-active enzyme would be crucial in a variety of industrial and biotechnological applications. The potential advantage of cold-adapted enzymes will probably lead to a greater annual market than for thermo-stable enzymes in the near future. This review includes latest updates on various microbial source of cold-active enzymes and their biotechnological applications.

Excellent interfacial compatibility of phase change capsules/polyurethane foam with enhanced mechanical and thermal insulation properties for thermal energy storage

The incorporation of phase change microcapsule (microPCMs) substantially augmented the temperature regulation capacity of foams, endowing it with outstanding application potential in numerous industrial domains. However, interfacial compatibility issues between the capsule and the substrate always exist and affect foam performance. In this study, a milli-meter macrocapsule (macroPCMs) containing microPCMs was prepared using calcium alginate gel as the second layer wall to physically improve the interfacial compatibility. And poly (N-hydroxymethyl acrylamide) was in situ polymerized in the gel layer and provided active alcohol hydroxyl groups to form chemical grafting with the polyurethane raw materials, which further chemically improved the interfacial compatibility. These measures created a significantly improved foam microstructure and a greatly increased foaming capacity, which thus endow the composite foam with excellent thermal insulation performance and mechanical strength. Compared with conventional microPCMs-based foam, the foaming capacity of the macroPCMs-based foam increased by 40 folds, the temperature regulation duration increased by 7 folds, and the mechanical performance increased by 3 folds. Moreover, the insulated incubator fabricated with the macroPCMs-based foam exhibited two-fold greater thermal insulation efficiency than conventional models containing internal ice incubator, which validated the potential of employing macroPCMs-based polyurethane foam in cold chain logistics applications.

The effect of cryotherapy on pain in patients with total knee replacement surgery: a meta-analysis.

Cryotherapy is used to reduce edema and pain after total knee replacement surgery. This study was conducted as a meta-analysis study to determine the effect of cryotherapy on pain in patients undergoing total knee arthroplasty. The words 'total knee prosthesis,' 'pain,' 'cryotherapy,' 'cold application,' and 'orthopedic surgery' were searched in Turkish and English in scientific articles in the last 20 years from Scopus, Science Direct, Google Scholar, Pubmed databases. As a result of the research, a total of 8.406 studies were identified. Funnel Plot, Rosenthal's Secure N, and Orwin's Secure N methods were used to demonstrate that the meta-analysis study was reliable and valid and to determine publication bias. The sample size of the studies included in the analysis was 1462. The total effect size was 2.929, with a lower bound of 1.641 and an upper bound of 5.223 at a 95% confidence interval. The study determined that patients who underwent cryotherapy in total knee replacement surgery had 2.9 times less pain than patients who did not undergo cryotherapy.

Mixed-Material Feedstocks for Cold Spray Additive Manufacturing of Metal–Polymer Composites

High-performance polymers such as poly(ether ether ketone) (PEEK) are appealing as composite components for a wide variety of industrial and medical applications due to their excellent thermomechanical properties. However, conventional PEEK metallization methods can often lead to poor quality control, low deposition rate, and high cost. Cold spray is a promising potential alternative to produce polymer–metal composites rapidly and inexpensively due to its relatively mild operating conditions and high throughput. In this study, we investigated the deposition characteristics of metal–polymer composite feedstock, composed of PEEK powder and copper flake in varying ratios, onto a PEEK substrate. Copper-PEEK powder blends were prepared by both hand-mixing and cryogenic milling (cryomilling), which predominantly creates composite particles with micron-scale copper domains coating PEEK particle surfaces. This process non-monotonically affects the relative dominance and length scales of the multiple contributing deposition mechanisms present in mixed-material cold spray. In low-pressure cold spray, deposits showed significant changes in deposition efficiency and composition as a result of milling, with improvements in these characteristics most dramatic at lower Cu fractions. Deposits of a cryomilled blend of nominally 30 vol.% copper in PEEK exhibited minimal porosity under scanning electron microscopy, complete retention of powder composition, and the highest deposition efficiency among all samples tested. Notably, neither neat PEEK nor neat Cu meaningfully deposited at the same mild conditions as this 30 vol.% Cu blend, indicating a synergistic departure from linear mixing rules driven by the relative balance of local deposition interactions (e.g., hard–soft, soft–soft, etc.). Intentional powder and process design toward optimizing this balance may facilitate cold spray metallization applications.

Application of cold wet road concrete mix with modified dispersed viscous bitumen for operative patch works

One of the directions of road surfaces operative patch works provision in spring period is the possibility of materials and technologies development of warehoused cold wet road concrete mix with clamp storage period is up to several years according to the technology of scientific school of professor Gornayev Nikolay Alekseevich of Saratov State Technical University. In this article the questions of cold wet road concrete mix application with modified dispersed viscous bitumen for patch work in Kuvandyk town of Orenburg region are considered. The time to repair the pothole after its discovery was 10 minutes. According to road workers with many years of experience, manual laying of asphalt mix with dispersed bitumen was not different in labour intensity from work with hot mix, while working conditions with cold mix were much better. Working mixture compaction brings water from the composition to the surface of the arranged asphalt concrete layer and, further, evaporates, and particles of viscous bitumen in the mineral material shell are destroyed and at the limits give the usual film coating of mineral particles in the form of mastic, various types of asphalt concrete and other asphalt materials. Two patents have been obtained by the authors on this technology. When the repair results were examined after three years, the facility was found to be in good condition.

Farklı Dozlarda Soğuk Plazma Tekniğine Maruz Bırakılan Domates Salçasının Fizikokimyasal ve Mikrobiyolojik Özelliklerindeki Değişikliklerin Belirlenmesi

This study aimed to reveal the effect of cold plasma application using different gases and mixtures on some physicochemical and microbiological properties of tomato paste. For this purpose, applications were performed in different gases and times, and the effect of each application was examined separately. As a result of the study, the pH values of the samples varied between 3.77 and 4.87, and the aw values between 0.718 and 0.819. When the color values were examined, it was determined that the L* value varied between 22.42 – 32.48, the a* value varied between 23.59 – 30.18 and the b* value varied between 12.16 – 19.52 (P

A Comprehensive Review on the Latest Insights into Cold Therapies and Their Impact on the Human Body, with a Focus on Neurophysiological Responses

Introduction In contemporary medicine, increasing attention is being devoted to alternative forms of therapy. Immersing oneself in cold water, cryotherapy, or cold showers are practices that have long sparked interest due to their potential health benefits. Aim of the study The aim of this comprehensive review is to analyze the impact of cold exposure on the human body, with particular emphasis on its effects on the nervous system. Through the synthesis of available research, the paper seeks to identify health benefits and areas requiring further investigation in the context of various cold application practices. Materials and methods An analysis of scientific articles available in the Pubmed and Google Scholar databases was conducted. Publications from recent years that most relevantly addressed the discussed topic were utilized for this study. The search process involved the use of the following keywords: “cold,” “cold showering,” “cold water,” “cryotherapy.” Results The results of the literature review unequivocally indicate a positive, multifaceted impact of cold on the human body, particularly with an emphasis on the nervous system. Significant therapeutic effects observed in various fields suggest that the application of cold may be a promising alternative in promoting health and treating numerous medical conditions. Summary The focused literature review on the impact of cold on the human body, especially the nervous system, presents various therapies such as cryotherapy or cold water immersion, emphasizing their beneficial effects on the nervous, cardiovascular, endocrine, lymphatic, musculoskeletal, and joint systems. However, despite the observed benefits, further research is needed to gain a more detailed understanding of the mechanisms of action and to ensure the safety of these practices.

Assessment, Treatment, and Follow-Up of Phlebitis Related to Peripheral Venous Catheterisation: A Delphi Study in Spain

Background: Phlebitis related to peripheral venous catheters (PVCs) is a common complication in patients who require these devices and can have important consequences for the patients and the healthcare system. The management and control of the PVC-associated complications is related to nursing competency. The present study aims to determine, at the national level in Spain, the consensus on the assessment, treatment, and follow-up of PVC-related phlebitis and the importance of the actions taken. Method: A three-round Delphi technique was used with clinical care nurses who are experts in the field of in-hospital intravenous treatment in Spain. For this, an online questionnaire was developed with three open-ended questions on the dimensions of phlebitis assessment, treatment, and follow-up. For the statistical analysis of the results, frequencies and percentages were used to determine consensus, and the measures of central tendency (mean, standard deviation, and the coefficient of variation) were used to rank importance. The coefficient of variation was set as acceptable at ≤30%. Results: The final sample was 27 expert nurses. At the conclusion of round 3, actions were ranked according to their importance, with six items included in the PVC-related phlebitis assessment (symptomatology/observation, redness, the Maddox scale, induration, temperature, and pain), two in treatment (catheter removal, pentosan polysulphate sodium ointment + application of cold), and just one in follow-up (general monitoring + temperature control). Conclusions: There is a major disparity in relation to the PVC-related phlebitis assessment, treatment, and follow-up actions. More clinical studies are therefore needed to minimise the complications associated with the use of PVCs, given their impact on the quality of care and patient safety and their economic cost.

Shotblocker or Cold Application; Which One is More Effective in Reducing Anxiety and Pain Associated with the Intramuscular Injection in Children?: A Randomized Controlled Trial

Shotblocker or Cold Application; Which One is More Effective in Reducing Anxiety and Pain Associated with the Intramuscular Injection in Children?: A Randomized Controlled Trial

The effect of cold gel pack application in the prevention of amiodarone-related phlebitis.

The purpose of this study was to evaluate the effect of cold application on amiodarone-related vein phlebitis. A quasi-experimental design was used. The study sample consisted of 79 patients who received an amiodarone infusion. The control group of the study consisted of patients receiving amiodarone treatment, while the intervention group consisted of patients receiving cold application during the amiodarone infusion. In the intervention group, after the start of amiodarone treatment, cold gel packs were applied a total of 12 times for 15 min at 2-h intervals. The rate of phlebitis development was 59% in the intervention group and 95% in the control group (p < .001). It was found that 52.2% of the patients in the intervention group had first grade phlebitis and 84.4% of the patients in the control group who developed phlebitis had second grade phlebitis (p < .001). The 15-min cold application was found to be effective in terms of the rate of phlebitis development, phlebitis grade and time of phlebitis development. (ClinicalTrials.gov NCT05058053).

The Effect of Alternating Application of Cold and Hot Compresses on Reduction of Breast Engorgement Among Lactating Mothers.

Breast engorgement is a common issue that affects breastfeeding initiation and continuation. Engorgement can cause exhaustion, making it difficult to care for and feed the infant, and it can cause a mother to wean her baby before she intends to initiate breastfeeding. This study aimed to determine the effectiveness of the alternating application of cold and hot compresses in reducing breast engorgement among lactating mothers. Design, sample size and setting: A quasi-experimental study design is used to conduct this study. A purposeful sample of 100 lactating mothers was screened in the postnatal ward for the presence of breast engorgement. The 100 mothers with engorgement were divided into two equal groups of 50 mothers each - the first group (the intervention) and the second group (the control) - at the postnatal ward of King Abdulaziz Hospital-National Guard in Alahsa City. Sampling and tools: The data collection was conducted over five months, from January 2023 until May 2023. Data collection was done through a structured interview questionnaire sheet. The questionnaire was divided into six parts: socio-demographic data, obstetric and initial women assessment, the six-point engorgement scale (SPES), the visual analog scale (VAS), the LATCH breastfeeding charting scale, and the Infant Breastfeeding Assessment Tool (IBFAT). The present study found no statistically significant difference between the study intervention and control groupsin breast engorgement, LATCH level, or overall level of breastfeeding assessment before the intervention. While, in terms of breast engorgement, pain level, attachment, and LATCH, the overall levels of infant breastfeeding assessment across study time had a statistically significant variance among the study and control groups after the intervention at p values=<0.001. The alternating application of cold and hot compresses can have a significant role in reducing breast engorgement among lactating mothers. Women should be encouraged to use hot compresses and cold gel packs as an alternative treatment to reduce engorgement and promote comfort. In addition, the study results can be utilized to aid Saudi Arabian nurses and midwives in understanding the advantages of applying a cold gel pack and a hot compress and to decrease levels of engorgement, improve latch, and relieve discomfort.

The Effect of Ice Massage Applied to the SP6 Point on Labor Pain, Labor Comfort, Labor Duration, and Anxiety: A Randomized Clinical Trial.

Acupressure and cold application are nonpharmacologic methods that midwives can use for labor pain. The purpose of this study was to determine the effects of ice massage applied to the SP6 acupressure point during labor on labor pain, labor comfort, labor duration, and anxiety. A single-masked, randomized controlled trial was conducted with 100 nulliparous women, including 50 in the intervention group and 50 in the control group. Rotational ice massage was applied to the SP6 point on both legs of the pregnant women in the intervention group at 4 to 5 cm, 6 to 7 cm, and 8 to 9 cm dilation amounts during 3 contractions. Routine oxytocin was administered to all pregnant women to promote progress of labor. Standard midwifery care was provided to the control group. Data were collected using a Personal Information Form, the Visual Analog Scale (VAS), a partograph form, the Childbirth Comfort Questionnaire (CCQ), and the State-Trait Anxiety Inventory State subscale. The VAS pain scores of the pregnant women in the intervention group were significantly lower compared with the control group following the intervention at dilatations of 4 to 5 cm, 6 to 7 cm, and 8 to 9 cm (P = .001, P = .003, P <.001, respectively). The total CCQ and comfort level scores of the pregnant women in the intervention group at 8 to 9 cm cervical dilatation were significantly higher than the control group (P = 0.044, P = .027, respectively). Additionally, as the anxiety levels of the pregnant women increased, their total comfort scores decreased (P <.05). Ice application to the SP6 point during stage 1 of childbirth reduced labor pain, increased comfort, and reduced anxiety levels. No adverse events were found in the intervention group with ice massage applied to the SP6 point. Therefore, this method can be used as a safe and effective midwifery intervention in childbirth.

The Effect of the Timing of Cold Application on Pain and Satisfaction in Patients With Fractures.

This experimental study used a repeated-measures design to examine the effect of the timing of cold application on pain and satisfaction in a sample of 60 patients who had fracture surgery. Cold was applied for 20 minutes each hour for four hours to patients assigned to the experimental group. Whereas cold was applied once to those in the control group: for 20 minutes during the first hour after surgery. Results following data analysis from repeated measurements of pain before and after cold application in both groups showed a significant difference between the groups ( p <.05). Patients' levels of satisfaction with nursing care practice were higher in the experimental group than in the control group, although not significantly ( p >.05). The pain score in the experimental group decreased significantly with each cold application. In the control group, the pretreatment pain score decreased significantly after one cold application, increasing again in 3 hours without cold application. These findings are important for nurses caring for postoperative patients and giving discharge instructions. Our findings suggest repeated cold applications for 20 minutes at hourly intervals may result in better overall pain reduction than a single cold application.