Objective To explore the effect of application of clinical nursing pathways on health education for patients with chemotherapy by PICC. Methods The 164 cases of patients with PICC lines were randomly divided into control group and experimental group. The control group underwent the traditional methods of health education. Experimental group of clinical nursing path model were guided to patients and their families. The items were compared between groups, such as the rate of mastering knowledge, quality of service satisfaction, health education, confidence in disease treatment, hospital days, complications. Results The healthy missionary of the compliance rate and satisfaction, knowledge and grasp of the PICC catheter rates,confidence in the treatment of the disease were significantly higher in experimental group. Patient days of hospitalization and complications were significantly lower than those of the control group ( P < 0.01).Conclusions PICC catheter path by application of clinical nursing care can increase health knowledge of the patients, improve the patient's satisfaction, save nursing human resources, and improve the quality of nursing service. Key words: Clinical nursing pathways; PICC; Health-education