Additional Applications Research Articles

Research Progress of Metal Additive Manufacturing Technology and Application in Space: A Review

Metal additive manufacturing in space is a cutting-edge technology that is designed to meet the needs of space exploration and space station construction. This technology is capable of customizing and repairing key metallic parts in a space microgravity environment, providing the feasibility for long-term space tasks. It enables astronauts to perform on-site repairs and replace broken parts, significantly reducing the risk of mission failure on the International Space Station or during future deep space missions. Further, this technique opens new possibilities for constructing space bases by directly utilizing the materials from space, thereby reducing reliance on Earth’s resources. However, metal additive manufacturing in space faces challenges due to the unclear underlying mechanisms that lie in (I) the significant differences in the melting behaviors of materials in a space microgravity environment compared to those on Earth; and (II) extreme environmental factors, i.e., radiation and temperature fluctuations, that influence the metal additive manufacturing process and, consequently, the properties of the manufactured materials. This review provides a comprehensive analysis of those mechanisms underlying metal additive manufacturing in space, based on published works. Emphasis is placed on aluminum, titanium, iron, and copper-based metals. Our work may offer valuable guidance for reducing mission costs, improving safety, and enabling the on-demand production of complex components in the harsh environment of space by using metal additive manufacturing.

Desktop Based Database System Learning Media Application Design with MS Visual Basic Net 8.0

In the modern era, information technology in education is becoming increasingly important. This is why creating a desktop-based database learning media application using Microsoft Visual Basic Net 8.0 is a strategic step to improve the efficiency and quality of education. Additional application programs that can be used to design and create learning media, particularly in math education, are the subject of this article. Visual Basic, a programming language that is also taught in many college degree programs, is one such application program that can replace teachers who need to provide exercises and examples.

A Simplified, CRISPR-Based Method for the Detection of Batrachochytrium salamandrivorans.

The fungal pathogen Batrachochytrium salamandrivorans (Bsal) is one of two species (the other, B. dendrobatidis/Bd) that cause amphibian chytridiomycosis, an emerging infectious disease that has been indicated in the declines of hundreds of amphibian species worldwide. While Bd has been near globally distributed for decades, Bsal is a more recently emerged pathogen, having been identified just over a decade ago with current impacts localized to salamandrids in parts of Europe. However, because there is concern that Bsal will cause widespread declines if introduced to naïve regions-such as the Americas where the greatest diversity of salamandrids exist-it is imperative that widespread monitoring strategies be implemented to mitigate the spread of Bsal. As standard molecular diagnostic approaches-such as qPCR-tend to be expensive, time-consuming, or require specialized instrumentation and training, we have developed a simplified, rapid, CRISPR-based approach for Bsal-DNA detection. Here, we demonstrate this approach-termed FINDeM (Field-deployable, Isothermal, Nucleotide-based Detection Method)-and show that it can detect clinically relevant concentrations of Bsal DNA in under an hour using only inexpensive supplies and body-heat inducible reactions. Further, we highlight drawbacks and limitations associated with FINDeM-such as decreased DNA extraction yields and detection sensitivity when compared to more traditional approaches-and provide suggestions for additional development and future application of this method.

Using computed tomogram atrial myocardial thickness maps in cryoballoon pulmonary vein isolation: The UTMOST AF II Randomized Clinical Trial.

Whether adjusting the duration of ablation based on left atrial wall thickness (LAWT) provides extra benefits for pulmonary vein (PV) isolation for atrial fibrillation (AF) is uncertain. We studied the safety and efficacy of tailored cryoballoon PV isolation (CB-PVI) based on LAWT for paroxysmal AF. 277 patients with paroxysmal AF refractory to anti-arrhythmic drug were randomized 1:1 to either LAWT-guided CB-PVI (n=135) and empirical CB-PVI (n=142). Empirical CB-PVI was performed using a 28-mm cryoballoon with recommended application for 240 seconds per ablation. Cryoapplication in the LAWT-guided group was titrated (additional application for 120 seconds at PVs, where >25% of the circumference includes segments with LAWT >2.5mm and reduced baseline application to 180 seconds at PVs where >75% of the circumference includes segments with LAWT <1.5mm) according to the computed tomogram-LAWT color map. The primary endpoint was freedom from any documented atrial arrhythmia of more than 30 seconds without antiarrhythmic medication, after a single ablation procedure. During a mean follow-up of 18.7 months, patients in the LAWT-guided CB-PVI group (70.8%) had a higher event-free rate from primary endpoint than those in the empirical CB-PVI group (54.4%; HR 0.64, 95% CI 0.42-0.99; P=0.043). No differences were observed between the groups in complication rates (3.0% in LAWT-guided vs. 4.9% in empirical CB-PVI). The total procedure time was extended in the LAWT group than in the empirical group (mean 70.2 vs. 65.2 minutes, respectively). The LAWT-guided energy titration strategy improved freedom from atrial arrhythmia recurrence, compared with conventional strategy.

Methodological Advances with Penalized Structural Equation Models

Penalized structural equation models (PSEM) is a powerful technique that unlocks a variety of new modeling frameworks. PSEM applications have been established previously for standard SEM and ESEM models. In this note we aim to extend these ideas to more general types of models such as finite mixture models, multilevel models as well as models with more general types of outcomes. Maximum likelihood and weighted least squares estimation methods naturally accommodate a penalty term. In Mplus 8.12 the PSEM methodology is implemented for all models that can be estimated with these two estimators. Therefore we can now easily combine the more general models with the features of PSEM such as EFA, Alignment, and parameter invariance. Some additional basic SEM applications are also included.

MOBILE APPLICATIONS AND SUICIDE: A SYSTEMATIC ANALYSIS ON THE EFFECTIVENESS OF MOBILE APPLICATIONS FOR SUICIDE PREVENTION

MOBILE APPLICATIONS AND SUICIDE: A SYSTEMATIC ANALYSIS ON THE EFFECTIVENESS OF MOBILE APPLICATIONS FOR SUICIDE PREVENTION ABSTRACT Objective: This study aimed to evaluate the effectiveness of mobile applications designed to prevent suicide. Design: Within the scope of the study, open access Turkish and English articles published in online databases (Web of Science, PubMed (MEDLINE), WİLEY, Taylor &amp; Francis Online, Science Direct) between 2019 and August 2024 were reviewed. Randomized controlled trials on mobile applications whose role in preventing suicide was clearly stated in the articles were included in the study. Results: As a result of the screening, seven studies that met the inclusion criteria were included in this study. In four of the included studies, a routine intervention (awareness training, psychotherapy or medical treatment) was compared with an additional mobile application; in three studies, a routine intervention was compared with a mobile application. As a result of the evaluation, different results were obtained in terms of the effectiveness, acceptability and usability of mobile applications. It was concluded that mobile applications with psychotherapy content, especially applied together with face-to-face interventions, provided more positive results in reducing the risk of suicide. However, the level of effectiveness may vary depending on the content of the application, the characteristics of the sample, and whether it is a treatment support. At the same time, it has been determined that mobile applications are usable but that there is limited data on their acceptability. Conclusion: Mobile applications aimed at preventing suicide are potential tools that can be used in preventing suicide. However, there is no definitive result regarding their effectiveness. It is important to increase randomized controlled studies with a large sample, long follow-up period, and high level of evidence. Keywords: Mental health, mobile application, suicide

A multilayer network-based framework for handling and comparing user histories in X

In this article, we propose a framework that uses a multimodal multilayer network to build, manage and compare User Histories in X. A User History not only considers the contents of interest to the user, as is generally the case with a User Profile. In fact, it also records the set of interactions she has made with contents, the timestamps when they happened, and, ultimately, the history of her actions and behaviour. This provides a more comprehensive view of the user, her preferences and needs and paves the way to a number of additional applications. Most of them need to compare two User Histories to calculate their similarity degree. Our framework proposes two approaches, one naive and one refined, to perform this task. We also mention an application that, along with others already proposed in the literature, can greatly benefit from User Histories with the aim of fostering people inclusiveness. Finally, we describe a set of experiments we conducted to evaluate the goodness of the proposed framework.

Development and validation of an analytical method for the simultaneous quantitation of posaconazole Form I and Form-S in oral suspensions

Any polymorphic conversion of an active pharmaceutical ingredient (API), even if partial, is likely to lead to changes in its efficiency and safety. Posaconazole, an antifungal drug, is detected as Form-S in the commercially available oral suspensions. However, a mixture of Form-S and the initial Form I is likely to coexist depending either on the manufacturing process of the suspensions and/or to the storage conditions of the suspension. The simultaneous quantitation of these crystal forms in suspensions is challenging because of the dose inhomogeneity and the instability of Form-S at ambient conditions. Although X-ray Powder Diffraction (XRPD) was initially employed, preferred orientation issues in the suspension inhibited the successful quantitative determination of the polymorphs. In order to circumvent the problem Raman spectroscopy was selected for addressing this challenge, while the additional application of a home-made rotation system reduced the inhomogeneity problems. A separate calibration curve was generated for each polymorph using a conventional linear regression. The combination of these two relations led to the formation of a comprehensive equation relating the characteristic Raman peak intensities of posaconazole Form-S and Form I with the concentrations thereof. The method was validated and the results were confirmed through a partial least square regression (PLSR). The detection limits for Form-S and Form I were determined equal to 1.9 mg/mL and 2.2 mg/mL, respectively.

Impact of Soil Amendments and Improved Alkaline Water on the Physico-chemical Characteristics of the Soil, the Distribution of Salt in the Soil, the Growth, and the Yield of Hybrid Cotton Grown in Sodic Soil with Drip Irrigation

The effects of ameliorated alkali water and soil amendments on the soil properties, growth, and yield of hybrid cotton in sodic soil under drip irrigation were investigated in this field experiment at Anbil Dharma lingam Agricultural College and Research Institute, Trichy, using cotton (RCH-20) as a test crop. The main-plot treatments included drip irrigation with gypsum treatment water and drip irrigation with spent wash treatment water; the sub-plot treatments included soil application of gypsum @ 50% GR (5.2 t ha-1) and a one-time soil application of distillery spent wash at 5 lakh liters ha-1. The treatment without amendments under main plot and sub-plots was used as a control. The experiment was designed in a strip-plot design with four replications. The application of additives through irrigation water or soil dramatically lowered the post-harvest soil's pH. Plots applied with wasted wash had the greatest pH reduction (M1S1) 7.81, followed by those applied with gypsum (M2S2) 7.90 and control (M3S3) 8.15. Because there was more soluble salt present in the spent wash treated plots, there was a little rise in EC. Drip irrigation with distillery spent wash (DSW) treated water and drip irrigation with gypsum treated water, respectively, resulted in ESP decreases of (M2S2) 0.97 and (M1S1) 0.61 over control. Similarly, ESP decreased by 2.63 and 1.31 when gypsum and DSW were applied to the soil, respectively, compared to the control. The organic carbon values ranged from (M3S3) 0.47 to (M2S2) 0.92 percent. In general, an increase in organic carbon content was observed in all the treatments that received amendments (Gypsum&amp; DSW) compared to control. Salt distribution pattern conducted in treatment of distillery spent wash @ 5.0 lakh liters ha-1 significantly increased vertical depth of soil pH ranges (7.56,7.68,7.80,8.30) and decreased EC ranges (1.05,1.02,1.00,0.95) followed by horizontal line soil pH ranges (7.54,7.51,7.49,7.50) and EC ranges (1.04,1.02,1.00,1.02) at 120 DAS after application. In the experimental field recorded vertical depth of soil increased pH and decreased electrical conductivity compared to horizontal distances of soil pH and EC. The physico- chemical properties reduced in treatment one time application of DSW @ 5 lakh liters ha-1 recorded the highest physico -chemical properties followed by the treatment receiving irrigation with gypsum bed treated alkali water and lowest was recorded in the untreated alkali water irrigated through drip system in non- amended soil.

Comparing DCE-MRI and DSA: Understanding the embolization of hypervascular spinal metastases.

This study aims to examine and compare the effectiveness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and Digital Subtraction Angiography (DSA) in evaluating hypervascular spinal metastases. A comprehensive literature review was conducted, utilizing top-tier databases such as PubMed, Scopus and Google Scholar, to compile an authoritative and up-to-date overview of the current advancements in the field. We synthesized key studies focusing on the advantages, limitations and efficacy of both imaging techniques. DCE-MRI provides a non-invasive method for evaluating tissue morphology, perfusion and vascularity, offering valuable information for cancer diagnosis and treatment monitoring. In contrast, DSA is an invasive procedure primarily used for embolization and diagnosing cerebrovascular events. Both modalities have distinct features regarding image acquisition, contrast agents, resolution and accessibility. DCE-MRI shows promise for cancer-related applications, offering advantages over conventional MRI by incorporating anatomical and hemodynamic parameters. While DSA remains important for cases requiring critical vascular information, further research is necessary to explore its potential therapeutic benefits in assessing vessel patency. Continued investigations are crucial to uncover additional insights and therapeutic applications for both DCE-MRI and DSA in medical imaging.

Utilization of Single-Pulse Transcranial-Evoked Potentials in Neurological and Psychiatric Clinical Practice: A Narrative Review.

Background: The utility of single-pulse TMS (transcranial magnetic stimulation)-evoked EEG (electroencephalograph) potentials (TEPs) has been extensively studied in the past three decades. TEPs have been shown to provide insights into features of cortical excitability and connectivity, reflecting mechanisms of excitatory/inhibitory balance, in various neurological and psychiatric conditions. In the present study, we sought to review and summarize the most studied neurological and psychiatric clinical indications utilizing single-pulse TEP and describe its promise as an informative novel tool for the evaluation of brain physiology. Methods: A thorough search of PubMed, Embase, and Google Scholar for original research utilizing single-pulse TMS-EEG and the measurement of TEP was conducted. Our review focused on the indications and outcomes most clinically relevant, commonly studied, and well-supported scientifically. Results: We included a total of 55 publications and summarized them by clinical application. We categorized these publications into seven sub-sections: healthy aging, Alzheimer's disease (AD), disorders of consciousness (DOCs), stroke rehabilitation and recovery, major depressive disorder (MDD), Parkinson's disease (PD), as well as prediction and monitoring of treatment response. Conclusions: TEP is a useful measurement of mechanisms underlying neuronal networks. It may be utilized in several clinical applications. Its most prominent uses include monitoring of consciousness levels in DOCs, monitoring and prediction of treatment response in MDD, and diagnosis of AD. Additional applications including the monitoring of stroke rehabilitation and recovery, as well as a diagnostic aid for PD, have also shown encouraging results but require further evidence from randomized controlled trials (RCTs).

StepFit-18K: Improving Irritable Bowel Syndrome (IBS) Symptoms with a Simple, Structured Walking Intervention.

Background: Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal (GI) disorder characterized by abdominal pain, altered bowel habits, and bloating, affecting approximately 10.1% of the global population. While current treatments emphasize dietary modifications and symptom management, emerging evidence suggests that physical activity (PA) may help alleviate IBS symptoms. This study evaluated the effects of a structured walking program, "StepFit-18K", on IBS symptom relief. Methods: A total of 106 participants (68 females and 38 males) completed the 12-week intervention, which consisted of 18,000 additional steps per week (6000 extra steps on three days per week) tracked via fitness devices. The program emphasized step count, ease of adoption, and social support through walking groups. Results: As assessed by validated questionnaires, significant reductions in GI symptoms were observed. The IBS Symptom Severity Score (IBS-SSS) decreased from 118.30 ± 98.73 to 74.46 ± 74.93, with a delta score of -43.84%, highlighting bloating as the most improved symptom. No clinically significant changes were observed in anthropometric or biochemical markers. Conclusions: StepFit-18K is a simple, accessible, and effective form of physical activity that has demonstrated therapeutic benefits for IBS symptoms. This offers an additional application beyond its well-established role in preventing cardiovascular diseases.

Investigating the Effect of Internet-Based Applications on Secondary School Students' Academic Achievement in Science, Motivation and Awareness of Web 2.0 Tools

In this study, the effect of internet-based applications on the academic achievement, motivation, and awareness of Web 2.0 tools of 6th grade middle school students on "Matter and Heat" was examined. The study group consisted of 73 (experimental: 50, control: 23) 6th grade students from a public school in Istanbul, Turkey. The study was conducted with an experimental design with pretest-posttest control group among quantitative research models. In the experimental group, science lessons were taught with the support of web 2.0 tools such as Nearpod, Canva and Quizizz, while in the control group, no additional application was made and the lessons were taught as specified in the curriculum. The data of the study were collected with the “Motivation Scale in Science Education”, “Matter and Heat Achievement Test” and “Awareness Scale for Web 2.0 Tools”. T-test and one-way factor analysis (ANCOVA) test were used to analyze the data. The results of this study showed that the academic achievement test scores of the experimental group students were higher than the control group and there was a significant difference between the academic achievement test scores of the experimental and control groups. The results showed that the science motivation scores showed a significant difference in favor of the experimental group and the science motivation scores of the experimental group students who were supported with web-based applications were higher than the control group. In addition, according to the results of the one-way analysis of covariance regarding the awareness of web 2.0 tools, there was a significant difference between the experimental group and the control group in favor of the experimental group in the post-test scores. In this study, the importance of planning and implementing science lessons supported by internet-based applications at the secondary school level was revealed.

Computer Simulation of Triazole-Modified Urethane Segments

The focus is on the development of siloxane-urethane block copolymer matrices for additive manufacturing applications, including soft robotics. Molecular dynamics simulations compare classical urethane segments with the triazole-modified ones, revealing temperature-dependent behaviors in their conformational structures. The results suggest the potential for tailoring the mechanical properties of polyurethanes through molecular modification, which is crucial for optimizing additive manufacturing processes. Further research could advance material design for customizable objects with desired mechanical response.

In situ Construction of Single-Atom Electronic Bridge on COF to Enhance Photocatalytic H2 Production.

Photocatalytic hydrogen production is one of the most valuable technologies in the future energy system. Here, we designed a metal-covalent organic frameworks (MCOFs) with both small-sized metal clusters and nitrogen-rich ligands, named COF-Cu3TG. Based on our design, small-sized metal clusters were selected to increase the density of active sites and shorten the distance of electron transport to active sites. While another building block containing nitrogen-rich organic ligands acted as a node that could in situ anchor metal atoms during photocatalysis and form interlayer single-atom electron bridges (SAEB) to accelerate electron transport. Together, they promoted photocatalytic performance. This represented the further utilization of Ru atoms and was an additional application of the photosensitizer. N2-Ru-N2 electron bridge (Ru-SAEB) was created in situ between the layers, resulting in a considerable enhancement in the hydrogen production rate of the photocatalyst to 10.47 mmol g-1 h-1. Through theoretical calculation and EXAFS, the existence position and action mechanism of Ru-SAEB were reasonably inferred, further confirming the rationality of the Ru-SAEB configuration. A sufficiently proximity between the small-sized Cu3 cluster and the Ru-SAEB was found to expedite electron transfer. This work demonstrated the synergistic impact of small molecular clusters with Ru-SAEB for efficient photocatalytic hydrogen production.

OPTIMIZATION OF THE PARAMETERS OF SYNTHESIZED SIGNALS USING LINEAR APPROXIMATIONS BY THE NELDER-MEAD METHOD

Context. The article presents the results of a study of the effectiveness of using the Nelder-Mead method to optimize the parameters of linear approximations of synthesized signals. Algorithms have been developed and tested that integrate spectral, temporal, and statistical analyzes and provide reasonable optimization. The effectiveness of the application of the Nelder-Mead method was proven by experiment. The obtained results substantiate the improvement of the properties of the mutual correlation of signals and the reduction of the maximum deviations of the side lobes, which opens up prospects for the further application of the method in complex scenarios of signal synthesis. Objective. The purpose of the work is to evaluate the effectiveness of the application of the Nelder-Mead method when adjusting the parameters of linear approximations to optimize the mutual correlation and minimize side deviations of complex synthesized signals. Method. The main research method is the comparison of various optimization algorithms for the selection of the most effective approaches in linear approximations of synthesized signals, taking into account such criteria as accuracy, speed and minimization of deviations. Scientific works [1, 2, 4–6, 8, 9] present algorithms, including the Nelder-Mead method and differential evolution. The effectiveness of these methods is achieved due to adaptive optimization procedures that improve the characteristics of signals. It is worth noting that the methods have disadvantages associated with high requirements for computing resources, especially when processing large data. This can be minimized using combined optimization methods that take into account the interaction of signal parameters. Another important direction of improvement is the optimization of methods for adaptation to dynamic changes in the characteristics of complex signals, which allows to achieve high adaptability and reliability of real-time systems. Results. As a result of the experiment using the Nelder-Mead method, an increase in the similarity of spectral densities was achieved from 0.52 in the first iteration to 0.90 in the fourth, with a significant decrease in the distance between the peaks of the spectrum from 1.2 to 0.4, which indicates high adaptability and the accuracy of the method in adjusting the parameters of the synthesizedsignals. Conclusions. The effectiveness of the Nelder-Mead method for adjusting the specified parameters of the synthesized signals was experimentally proven, which is confirmed by a significant improvement in the similarity of the spectra with each iteration. This opens the way for additional optimizations and application of the method in various technological areas.

Foundation Model Study on Inorganic and Biopolymer Nano Additives Treated Soil—A Step Forward in Nano Additive Soil Stabilization

For almost a decade, various studies have been carried out to prove the suitability of nano additives in enhancing the geotechnical properties of soil. Yet, this line of research is still in its elementary stage, restricting itself to laboratory tests to determine soil’s index and engineering properties blended with varying dosages of nano additives. In other words, research on practical applications of nano additives for soil stabilization is scarce. The present work attempts to investigate the suitability of three different nanomaterials as a load-bearing stratum for shallow foundations. The nano additives were chosen in such a way that each of them is from a different origin. One of them is nano calcium carbonate (inorganic) whereas the other two are nano-sized varieties of natural biopolymers, namely nano chitosan (crustacean-based) and nano carboxymethyl cellulose (plant-based). A series of laboratory tests were initially conducted to determine the strength of all three nano-additive-treated soils at different dosages, which were investigated for 180 days to ensure their long-term performance. This was followed by a foundation model study on untreated soil and on soil treated with optimal dosages of nano additives. The results were validated using finite element software followed by a parametric study to optimize the depth of soil stabilization. It was observed that all three nano additives exhibited a better performance when the top layer had the optimal dosage and the subsequent layers had a relatively lesser dosage.

Applicability of low sodium additives in sea food processing

Applicability of low sodium additives in sea food processing

Effect of an Additional Hydrophobic Adhesive Layer Application on the Clinical Performance of Class V Resin Composite Restorations: An 18-month Randomized Clinical Trial.

This study aimed to evaluate the 18-month clinical performance of two different one-step adhesives that were applied alone or with an additional hydrophobic adhesive layer to noncarious cervical lesions. One hundred sixty teeth in 31 patients were included in the study. Each patient received at least four restorations. A 2-hydroxyethylmethacrylate (HEMA)-containing one-step self-etch adhesive (Clearfil S3 Bond Plus, Kuraray Noritake, Noritake, Japan) and a HEMA-free universal adhesive (G-Premio Bond) were applied to noncarious cervical lesions with or without additional hydrophobic adhesive (Heliobond) randomly. Teeth were restored with a nanohybrid composite. Restorations were evaluated according to FDI criteria at baseline, 6-, 12-, and 18-month recalls. Data were analyzed with the Kruskal-Wallis and the Friedman analysis of variance (ANOVA) tests (α=0.05). At 18 months, recall rates were 100%, and there was no significant difference between four different adhesive applications in terms of any criteria (p>0.05). The cumulative retention rates were 92.5%, 92.5%, 97.5%, and 100% for the restorations with one-step self-etch, one-step self-etch plus hydrophobic adhesive layer, a universal adhesive, and a universal adhesive plus hydrophobic adhesive layer, respectively. An additional hydrophobic adhesive layer was found to have no significant effect on the 18-month clinical performance of two different one-step adhesive systems with and without HEMA.

Efficacy of Disinfectants for Monkeypox Virus Inactivation on High Touch Surface Materials in Low-Resource Settings.

Disinfection efficacy tests were conducted on surface carriers inoculated with the monkeypox virus (MPXV) by applying six disinfectant solutions (and three controls) on six surfaces common in low-resource settings: four nonporous surfaces (stainless steel, glass, plastic, and latex) and two porous surfaces (ceramic and wood). Disinfectants were wiped on carriers in triplicate, with a 1 min contact time: 0.05 and 0.5% sodium hypochlorite, 70% ethanol, two quaternary ammonium compound (QAC)-based disinfectants, and 1.4% hydrogen peroxide. MPXV was then quantified, and log10 removal values were calculated. Sodium hypochlorite (0.05 and 0.5%) and ethanol (70%) removed MPXV to below detection level, ≥ 99.97% reduction for nonporous surfaces, and ≥99.40% for wood, QAC-based disinfectants were efficacious on nonporous surfaces (≥99.97% inactivation) but had diminished efficacy on wood, a porous surface, and 1.4% H2O2 had limited efficacy across all tested surfaces. Results varied by disinfectant type and surface type. Based on our results, we recommend using 0.05% sodium hypochlorite or 70% ethanol with 1 min contact time to inactive MPXV on clean nonporous and porous surfaces. As MPXV is evolving, future research with additional disinfectants, application methods, and environmental conditions and research to understand adsorption, disinfection efficacy, and transmission risk on porous surfaces are needed to develop practical disinfection recommendations.