Application Of 3D Model Research Articles

Three-dimensional finite element modeling for evaluation of laryngomalacia severity in infants and children.

This study was performed to investigate the feasibility of using a three-dimensional (3D) finite element model for laryngomalacia severity assessment. We analyzed laryngeal computed tomography images of seven children with laryngomalacia using Mimics software. The gray threshold of different tissues was distinguishable, and a 3D visualization model and finite element model were constructed. The laryngeal structure parameters were defined. The peak von Mises stress (PVMS) value was obtained through laryngeal mechanical analysis. The PVMS values of the laryngeal soft tissue and cartilage scaffolds were independently correlated with disease severity. After stress loading the model, the relationship between laryngomalacia severity and the PVMS value was apparent. However, the PVMS value of laryngeal soft tissue was not correlated with laryngomalacia severity. This study established the efficacy of a finite element model to illustrate the morphological features of the laryngeal cavity in infants with laryngomalacia. However, further study is required before widespread application of 3D finite element modeling of laryngomalacia. PVMS values of the laryngeal cartilage scaffold might be useful for assessment of laryngomalacia severity. These findings support the notion that structural abnormalities of the laryngeal cartilage may manifest as quantifiable changes in stress variants of the supraglottic larynx.

Three-dimensional culture models to study drug resistance in breast cancer.

Despite recent advances in breast cancer treatment, drug resistance frequently presents as a challenge, contributing to a higher risk of relapse and decreased overall survival rate. It is now generally recognized that the extracellular matrix and cellular heterogeneity of the tumor microenvironment influences the cancer cells' ultimate fate. Therefore, strategies employed to examine mechanisms of drug resistance must take microenvironmental influences, as well as genetic mutations, into account. This review discusses three-dimensional (3D) in vitro model systems which incorporate microenvironmental influences to study mechanisms of drug resistance in breast cancer. These bioengineered models include spheroid-based models, biomaterial-based models such as polymeric scaffolds and hydrogels, and microfluidic chip-based models. The advantages of these model systems over traditionally studied two-dimensional tissue culture polystyrene are examined. Additionally, the applicability of such 3D models for studying the impact of tumor microenvironment signals on drug response and/or resistance is discussed. Finally, the potential of such models for use in the development of strategies to combat drug resistance and determine the most promising treatment regimen is explored.

Modelling the Process of Processing Ash and Slag Wastes of TPP by Means of Consistent Application of CAE- and CAD- systems

The article considers the possibility of joint application of mathematical processing and computer 3D modeling of the technological process line for processing ash and slag waste from thermal power plants (TPP). The authors suggest considering an approach to the design of the ash and slag waste processing site by mathematical processing and 3D computer modeling. The mathematical processing with the help of E- network device and the creation of a 3D model allows to plan the site for processing ash and slag waste, select the appropriate technology and thereby ensure the environmental effect of both existing and projected power plants. The authors present the results of processing the technological process of recycling ash and slag wastes of TPP in terms of E-networks using mathematical processing in the Simulink application, which displays the device model from the standard blocks available in the program and performs the necessary calculations. 3D models of individual equipment units selected on the basis of mathematical processing calculations in the Simulink application, were created using computer 3D modeling in a graphical editor. A 3D visualization of the technological section of ash and slag waste processing was performed, which allows to clearly show the planned section at the design stage, which, if necessary, will allow to easily make changes to the project.

Практическое применение биотехнологий трехмерного клеточного культивирования в онкологии и персонализированной терапии

The creation of in vitro three-dimensional cellular model systems (in vitro 3D cultures) is a fast-growing leading-edge segment of the biotechnological industry. We have examined in this work the key 80 articles published after 2008, and focused on applications of in vitro 3D culture in translational oncology. We described a broad range of 3D culture systems, including models with and without extracellular matrix (ECM). 3D culture models based on decellularized ECM were discussed in more detail. The role of ECM in pathogeneis of malignant neoplasms, in particular, in the phenomenon of the tumor resistance to chemotherapy, was evaluated. 2D and 3D culture systems were compared, and natural and synthetic ECM were described, as well as the model creation based on 3D bioprinting. Particular attention was paid to in vitro models of various cancers, including those at the metastatic stage, based on 3D cell cultures, which maximally mimic the in vivo tumor behavior. The prospects of the practical application of 3D cell culture models in preclinical drag screening and in personalized therapy were discussed. We also presented our data on in vitro 2D and 3D culturing of human cells on various substrates. 3D cellular models, 3D bioprinting, biotechnology, extracellular matrix, cancer, translational medicine, personalized medicine, drag development, in vitro, ex vivo, oncology The authors are grateful to Dr. E. Shabalina for providing part of the experimental data and to OKA-Biotech Company for the samples of recombinant Funding-The work was supported by a Grant from the Russian Science Foundation (no. 18-15-00391). doi: 10.21519/0234-2758-2020-36-3-3-15

Application of 3D Model of Cancer Cells in Research on the Effectiveness of BNCT in the Treatment of Melanoma

Application of 3D Model of Cancer Cells in Research on the Effectiveness of BNCT in the Treatment of Melanoma

Augmented Reality as Learning Medium for Preservation of Traditional Musical Instruments in Bangka

Nowadays the use of technology is something that can be found anywhere. This condition has an impact on the loss of awareness of the Indonesian cultural treasures value in the form of traditional tools. No exception to traditional musical instruments on Bangka Island which began to lose its popularity. At present, most teenagers on Bangka Island cannot play traditional musical instruments. Likewise with the children who do not know and not even know their own regional musical instruments. With the continuation of this condition, it is feared that the existence of traditional Bangka musical instruments will disappear, as well as human resources that can play it. Augmented Reality (AR) is a visual technology that can display objects in 3D. The advantage of this technology is being able to give a display of real-time musical instrument in the form of dynamic 3D visualization of objects and it is in accordance with the movements of the user's smartphone camera. AR has also been applied in various cases as a solution to problem-solving. Therefore, to overcome this problem, an application to preserve the traditional Bangka musical instruments using Augmented Reality (AR) is forming. The 3D objects of musical instruments are made using Maya. Unity is also used as an engine for the application of 3D modeling on the Android system, and Vuforia SDK as it’s augmented reality engine. The results of performance testing obtained 100% running well. From the results of testing the user experience with the HARUS method, it is proven that the system has comprehensibility aspects of 75.98% and manipulability aspects of 80.74% so that the total value HARUS be 78.36%.

Hybrid Scene Structuring for Accelerating 3D Radiative Transfer Simulations

Three-dimensional (3D) radiative transfer models are the most accurate remote sensing models. However, presently the application of 3D models to heterogeneous Earth scenes is a computationally intensive task. A common approach to reduce computation time is abstracting the landscape elements into simpler geometries (e.g., ellipsoid), which, however, may introduce biases. Here, a hybrid scene structuring approach is proposed to accelerate the radiative transfer simulations while keeping the scene as realistic as possible. In a first step, a 3D description of the Earth landscape with equal-sized voxels is optimized to keep only non-empty voxels (i.e., voxels that contain triangles) and managed using a bounding volume hierarchy (BVH). For any voxel that contains triangles, within-voxel BVHs are created to accelerate the ray–triangle intersection tests. The hybrid scheme is implemented in the Discrete Anisotropic Radiative Transfer (DART) model by integrating the Embree ray-tracing kernels developed at Intel. In this paper, the performance of the hybrid algorithm is compared with the original uniform grid approach implemented in DART for a 3D city scene and a forest scene. Results show that the removal of empty voxels can accelerate urban simulation by 1.4×~3.7×, and that the within-voxel BVH can accelerate forest simulations by up to 258.5×.

Fast encryption scheme for 3D models based on chaos system

With the development of multimedia applications, the application of 3D models becomes more and more popular, and its security has become an urgent problem to be solved. 3D objects have more complex spatial structures than 1D and 2D objects. Most of the previous work is to encrypt 3D objects directly, and this kind of algorithm is often tedious and the encryption time is long. Therefore, a new fast image encryption scheme based on chaos theory is proposed in this paper. In this scheme, the 3D object is transformed into 2D object (similar to image format), and then encrypted. The encryption process is divided into two stages: confusion stage and diffusion stage. In the confusion phase, we introduce random points. In the diffusion phase, we split the floating-point data, the integer part is encrypted by XOR, and the decimal part is scrambled only. The experimental results show that the scheme can encrypt and decrypt the 3D model correctly. The numerical results in security analysis are close to the ideal value, which shows that the scheme can resist common attacks and has high security.

Karst recharge-discharge semi distributed model to assess spatial variability of flows

Aquifer recharge assessment is a key factor for sustainable groundwater resource management. Although main factors of the spatial and temporal variability of recharge are known, taking them into account in a distributed or semi-distributed model is still a challenging task. This difficulty is increased in karst environments. Indeed, recharge of karst aquifers also depends on the organization of the karst network, which is both highly heterogeneous and difficult to characterize.We developed a reservoir model to simulate the spatial and temporal variability of recharge on karst watersheds. Special attention was paid to the link between model parameters and measurable or qualitative environmental factors of recharge. The spatial variability of soil reservoir capacity was estimated by multifactorial modelling (neural network). Intrinsic vulnerability indices were used to constrain the partitioning between slow and fast flows within the karst aquifer. Comparison of simulated and measured discharge at the outlet was used to calibrate and assess recharge model.The karst hydrosystem of the Fontaine de Vaucluse is renowned for its significant heterogeneity and anisotropy, which has so far limited the application of 2D or 3D modelling. The model developed was successfully applied to this system. Our results showed that the annual recharge is very heterogeneous on the test site. Spatialization of recharge improves discharge modelling as evidenced by increased KGE (from 0.8 to 0.9) and more realistic flows during drought periods. It is therefore essential to spatialize recharge in karst hydrogeological modelling to improve predictive capacity and better understand functioning of the whole hydrosystem.

Evaluation of Tooth No. 2674 and ESCO Tooth 3D models

Abstract The expense of restoring of excavators cutting bodies is increasing these days in the Most Basin area, primarily the replacement of tooth because of abrasion expense. The main reason is the complicated geological situation of overburden rocks, first of all the occurrence of sands and hard structures in the overburden cuts rocks in the deep horizons of open pit mines. Description of the first part of the strength analysis and applicability of 3D models of the tooth serial number 2673 and the tooth ESCO Super V39VYH with application of finite element method (FEM) is the main topic of this article. This research is the stage of the project based on optimisation of the shape and primarily the material used during manufacturing of the mining and ground machines cutting bodies in concrete mining conditions. The research is going on with application of new knowledge in the field of material engineering, metallurgy, cryogenic and nanotechnology. The main target is the increasing of mining process efficiency and the mining machines key node lifetime. Research of the excavator tooth parameters described in this article is very important part of the research.

3D Models Revolutionizing Surgical Outcomes in Oral and Maxillofacial Surgery: Experience at Our Center.

New technological advances have revolutionized the field of oral and maxillofacial surgery. The three-dimensional (3D) models are new technological breakthroughs which have equipped the oral and maxillofacial surgeon to effectively reproduce or improve preoperative form and function. They have also allowed the surgeon to achieve minimal operative and postoperative morbidity. In this case series, we present the clinical application and benefits of 3D models that are used for the surgical planning and execution of surgery in treating a case of mid-face deficiency and for the treatment of extensive jaw pathologies using reconstruction plate bent preoperatively, which contributed to improved surgical outcomes and patient satisfaction.

Rich-information watermarking scheme for 3D models of oblique photography

The security issues of copyright information arise rapidly along with the widely application of 3D models of oblique photography. In this paper, a reversible watermarking scheme is proposed for 3D models of oblique photography, aiming at robustness enhancing and rich-information watermark embedding. To realize the goal of rich-information watermark embedding, an encoding method of original copyright information is designed based on QR code, which can shorten significantly the length of the final watermark data without affecting the copyright expression. A 3D point grouping method is designed and both watermark embedding and extraction are completed group by group, so that the robustness of this scheme under certain attacks can be enhanced, e.g., model segmentation, data compression, point randomly deleting, etc. Moreover, watermarks are embedded into spherical coordinates of 3D points so that the ability of the proposed scheme in resisting geometric transformation can be improved. Results of simulation experiments have demonstrated that the proposed scheme can support rich-information watermark embedding, and it has a satisfying robustness under common geometric and non-geometric attacks.

Imagining the Past? Architecture and Public Rituals in Early Modern Lisbon, Madrid and Valladolid

This article discusses the application of architectural drawing and 3D modelling as suitable digital heritage methods for the study of ephemeral and residential architecture in sixteenth-century Iberia. Public rituals transformed spaces of social encounter in early modern cities. Learning how these urban spaces were decorated for such rituals is often challenging, for our knowledge of ephemeral displays and the residential architecture that composed the streetscapes of cities can be slim. Visual sources of ephemera, surviving early modern buildings and depictions of streetscapes can be scant. However, urban theories on early modern urbanism, theatre and space have demonstrated that ephemeral and permanent residential architecture are crucial for our understanding of festival culture. This paper examines the digital re-creation of the ephemera of the Lisbon ceremonial entry of 1581 through the lens of notions of authenticity in conservation theory and practice. It also explores early modern reforms in residential architecture in Madrid and Valladolid as a vehicle to examine the relationship between ritual and urbanism. This latter case study shows how digital re-creations aided the identification of primary visual sources and problematizes the use of digital heritage visualization as a tool for the analysis of urban historic environments.

Rapid Condition Surveys of Archaeological Excavations: Training Professionals in Two Minoan Sites on East Crete, Greece

Over the past century, monumental architecture has been at the center of attention of heritage professionals, stakeholders, and the public. On the contrary, vernacular architecture, which constitutes the majority of our built heritage, especially at rural sites in the provinces of Greece and other Mediterranean countries, has been mostly neglected and often has fallen into disarray. As a result, we now witness the severe degradation of several important settlements, which are threatened due to long exposure to the elements and lack of conservation, maintenance, and management plans. Since 2015, the Architectural Conservation Laboratory, University of West Attica, organizes a field-training program at the Minoan sites of Mochlos and Pseira on East Crete, aimed at addressing the challenges of vernacular architecture and raising awareness. The program provides on-the-job training opportunities to heritage professionals in surveying, assessing, and documenting the condition of architectural remains and finally establishing the conservation priorities. This paper discusses the approaches and the goals of the program, as well as the potential for the integration of cost-effective digital documentation techniques, such as photogrammetry, into the systematic monitoring of archaeological sites under threat. The preliminary results of the condition survey of Pseira and the challenges in the application of image-based 3D modeling on site are also reported.

Application of 3D skin culture model as a tool to study the role of immune mechanisms in chronic diabetic foot ulcers pathogenesis

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Methodological and Application Aspects of Indirect Analytical Determination of Coating Thickness on Metal-Coated Superabrasive Grits

The paper reviews the publications addressing the determination of the coating thickness on metal-coated grits of superhard materials. The available approaches to defining this problem have been analyzed and the methodological features of solving it have been studied. The present investigations have demonstrated that in the case where the actual 3D shape of a grit is a priori unknown the most appropriate approach is that which includes the outer specific surface in the coating thickness calculations. The author has been the first to propose to use an extrapolation-affine 3D model of a grit in such calculations. For synthetic diamond grits AS125 400/315 as an example, this 3D model has been shown to have a definite advantage over a sphere- and cube-shaped 3D model. The application of the extrapolation-affine 3D model of a grit provides a more accurate determination of the coating thickness on metal-coated diamond grits. The proposed method based on this methodological innovation is also suitable for grits of other abrasive materials.

The application of 3D modeling and spatial analysis in the study of groundstones used in wild plants processing

In recent years, several works have proved the reliability of the application of 3D modeling and spatial analysis in the study of stone tool use. Monitoring surface morphometry resulting from the use of lithic tools has the potential to objectively quantify and identify patterns of modifications associated to specific activities and worked materials. In particular, the combination of surface morphometry with a systematic experimental framework and use wear analysis has the potential of foreseeing residue distribution areas over the groundstone surfaces, hence providing a key aid in establishing sampling strategies applied to archeological specimens. Here, we propose an approach that applies 3D modeling, performed through a close-range photogrammetry, and the use of GIS software to investigate surface modifications and residue distribution on groundstones used to process wild plants. Our work comprises a dedicated experimental framework in which modern tool replicas have been used to process different species of wild plant foods through grinding, crushing, and pounding. By applying 3D modeling and spatial analysis, we were able to characterize patterns of surface modifications related to each of the worked substances and activities performed. Moreover, we monitored the distribution of starch granules over the experimental groundstone surfaces and its variation in relation to the state of the worked substance and the action carried out. Our results provide one of the first experimental dataset focused on the use of groundstones for wild plant processing, and a reliable methodology for further studies related to the exploitation of stone technology and wild vegetal substances in the past.

Using 3D-Printed Models to Advance Clinical Care

Structural Heart is a new field within the division of cardiovascular service lines. Structural heart has broadened the scope of delivery of cardiovascular care with its ability to deliver new valves and devices to heart patients who were once turned down for traditional open-heart surgery through the use of transcatheter delivery systems and device designs. However, in the absence of an open-surgical field, the main limitation in transcatheter device development and patient-centric care is the inability of the Structural Heart Implanter to palpate the patient’s cardiac anatomy for device sizing and delivery. Application of 3D printing and 3D modeling are becoming a useful toolkit for Structural Heart Implanters, Imagers, and Device specialists within the Heart Team to use as a communication tool and case planning resource to optimize patient care, and patient safety. Transcatheter interventions have revolutionized not only the field of cardiology, but additionally the field of biomedical engineering within Cardiovascular Medicine through the incorporation of 3D simulation technology.

Evaluation of the Applicability of 3d Models as Perceived by the Students of Health Sciences.

The methodology and style of teaching anatomy in the faculties of Health Sciences is evolving due to the changes being introduced as a result of the application of new technologies. This brings a more positive attitude in the students, enabling an active participation during the lessons. One of these new technologies is the creation of 3D models that reliably recreates the anatomical details of real bone pieces and allow access of anatomy students to bone pieces that are not damaged and possess easily identifiable anatomical details. In our work, we have presented previously created 3D models of skull and jaw to the students of anatomy in the Faculties of Health Sciences of the University of Salamanca, Spain. The faculties included were odontology, medicine, occupational therapy nursing, health sciences and physiotherapy. A survey was carried out to assess the usefulness of these 3D models in the practical study of anatomy. The total number of students included in the survey was 280.The analysis of the results presents a positive evaluation about the use of 3D models by the students studying anatomy in different Faculties of Health Sciences.

Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models.

Neurological disorders have emerged as a predominant healthcare concern in recent years due to their severe consequences on quality of life and prevalence throughout the world. Understanding the underlying mechanisms of these diseases and the interactions between different brain cell types is essential for the development of new therapeutics. Induced pluripotent stem cells (iPSCs) are invaluable tools for neurological disease modeling, as they have unlimited self-renewal and differentiation capacity. Mounting evidence shows: (i) various brain cells can be generated from iPSCs in two-dimensional (2D) monolayer cultures; and (ii) further advances in 3D culture systems have led to the differentiation of iPSCs into organoids with multiple brain cell types and specific brain regions. These 3D organoids have gained widespread attention as invitro tools to recapitulate complex features of the brain, and (iii) complex interactions between iPSC-derived brain cell types can recapitulate physiological and pathological conditions of blood-brain barrier (BBB). As iPSCs can be generated from diverse patient populations, researchers have effectively applied 2D, 3D, and BBB models to recapitulate genetically complex neurological disorders and reveal novel insights into molecular and genetic mechanisms of neurological disorders. In this review, we describe recent progress in the generation of 2D, 3D, and BBB models from iPSCs and further discuss their limitations, advantages, and future ventures. This review also covers the current status of applications of 2D, 3D, and BBB models in drug screening, precision medicine, and modeling a wide range of neurological diseases (e.g., neurodegenerative diseases, neurodevelopmental disorders, brain injury, and neuropsychiatric disorders). © 2019 American Physiological Society. Compr Physiol 9:565-611, 2019.