Application Of 3D Model Research Articles

Application and progress of 3D tumor models in breast cancer.

Due to its high heterogeneity and significant impact on women's health globally, breast cancer necessitates robust preclinical models to understand tumor biology and guide personalized treatment strategies. Three-dimensional (3D) in vitro tumor models hold immense promise in this regard. These tumor models not only mimic the spatial structure and growth environment of tumors in vivo, but also retain the pathological and genetic characteristics of solid tumors. This fidelity makes them powerful tools for accelerating advancements in fundamental research and translational medicine. The diversity, modularity, and efficacy of 3D tumor models are driving a biotechnological revolution. As these technologies become increasingly sophisticated, 3D tumor models are poised to become powerful weapons in the fight against breast cancer. This article expounds on the progress made in utilizing 3D tumor models for breast cancer research.

The Role of Human Factors, Ergonomics, and 3D Modeling When Evaluating Incidents Involving Micromobility Devices: An E-Scooter Fall Case Study

Micromobility devices—encompassing a range of lightweight devices such as bicycles, pedal-assist bicycles, e-bikes, e-scooters, mopeds, and electronic skateboards—are promising as a complement to existing modes of travel. Human factors and ergonomics professionals can leverage available technology, education, and experience to assess aspects of human behavior, perception, expectations, performance, and kinematics when interacting with micromobility devices. This study discusses the application of Human Factors and 3D modeling when assessing micromobility devices during real-world incident investigations and showcases various tools that can be used for these types of assessments. This article outlines an incident case study involving an operator-owned e-scooter purchased from the manufacturer.

The Emerging Role of Three-dimensional Technologies in Orthoplastic Surgery.

Three-dimensional (3D) planning and manufacturing technologies have become integral to head and neck reconstruction following tumor resection. These technologies facilitate the prototyping of patient-specific solutions in both digital and physical form. Three-dimensional tumor models and cutting guides help conceptualize and verify the surgical approach, as well as serve as a blueprint for reconstruction. Computer-aided renderings have been shown to add precision to bony contouring to achieve functional and aesthetic goals following tumor resection, such as in mastication, oral competence, speech, and symmetric facial aesthetics. Three-dimensional technologies have also been introduced in orthopedic oncology, making limb-salvage surgery the mainstay of treatment in cases where amputation was historically required. The advent of customized 3D cutting guides and plates allows surgeons to spare surrounding healthy tissue, markedly enhancing postoperative quality of life and significantly reducing associated morbidities. Borrowing from these applications of 3D planning and modeling, our institution has recently implemented these technologies for the reconstructive planning of soft tissue defects following sarcoma resection. Here we present a series of cases that demonstrate the workflow and clinical outcomes associated with the utilization of 3D planning techniques in orthoplastic surgery.

3D models for mohs micrographic surgery: a review on its use in patient education.

The use of a 3D model for patient education has shown encouraging results in surgical specialties like plastic surgery and neurosurgery, amongst many others; however, there is limited research on the clinical application of 3D models for Mohs Micrographic Surgery. This study delves into the utilization of 3D models for patient education in Mohs Surgery by juxtaposing different 3D modalities, highlighting their differences, and exploring potential avenues for future integration of 3D models into clinical practice. A literature search in the scientific database MEDLINE through PubMed and OVID and on the ProQuest Health & Medical Collection database was performed on the use of a 3D model for patient education. We limited the search to articles available in English and considered those mentioning the educational use of 3D models, especially for patient education, after excluding duplicate titles. We did not exclude articles based on publication year due to limited availability of literature. Utilizing 3D models for patient education within the framework of Mohs Micrographic surgery, including a 3D multicolored clay model and a 3D model accompanied by an educational video intervention, presents substantial advantages. 3D models offer a visual and tactile means to improve patients' comprehension of the Mohs procedure, the affected area, and possible outcomes. They hold the potential to reduce patient anxiety and improve decision-making. Currently, literature on the use of 3D models for patient education in Mohs Micrographic Surgery is limited, warranting further research in this area.

Cultural Relics Restoration Technology in Virtual Reality: Application of 3D Modeling and Rendering Algorithms in Cultural Relics Digitization

Cultural Relics Restoration Technology in Virtual Reality: Application of 3D Modeling and Rendering Algorithms in Cultural Relics Digitization

Applications of 3D modeling in cryptic species classification of molluscs

Applications of 3D modeling in cryptic species classification of molluscs

Study of Early Iron Age Vessels Using 3D-Modeling (Based on Baraba, Sargat Culture): Metric Characteristics

Purpose. The purpose of the paper is to approve and identify the possibilities of 3D modelling in the study of the Early Iron Age vessels.Methods. A series of experiments comparing computer and manual measurements of the vessels metric characteristics have been carried out (corolla diameter and vessel height). The experiments are based on 3D-models of three Early Iron Age vessels: a complete round-bottom vessel; a complete flat-bottom vessel; a fragmented round-bottom vessel. The respondents are represented by two groups: Iron/Bronze age and Stone Age researchers. The methods of statistics and arithmetic were used to process the results. The obtained computer and manual metric characteristics were subjected to arithmetic and statistical analyses.Results. It was revealed that the differences in measuring the corolla diameter between two groups were 0.1–1 mm. Measurements of vessels height by Stone Age researchers are more exact: the difference at the minimum discrepancies is less than 1 mm, the maximum values diverged up to 7 mm. According to the results of preliminary statistical analysis, there are no differences between the researcher groups on metric measurements of vessels. Statistical analysis showed that the results of manual measurements of simple objects (corollas) are sufficiently accurate and can be used for research. If a complex object (the complete vessel) is to be measured, it is better to use computerised measurements. Manipulation of high-precision artefact measurements is possible through the application of 3D-modelling.

Point cloud registration method for indoor depth sensor acquisition system based on dual graph computation with irregular shape factors

AbstractThe registration performance determines the widespread indoor application of 3D models acquired by depth sensors. Many advanced registration methods lack comprehensive feature aggregation and poor generalization capabilities, which improves the mismatching ratio. Here, a dual graph network is proposed by incorporating irregular shape factors to make point cloud features more expressive. At first, we transform point cloud sets into the stellar graph within the local neighbourhood of each point. The deep feature and shape factor of each point are combined in the directional‐connected irregular projection space. Subsequently, the combined features are modelled as the second graph. By the attention mechanism computation, feature information is continuously aggregated with intra‐graph and inter‐graph. Finally, a loss function is utilized to confirm point correspondence and perform the registration through singular value decomposition. Extensive experiments validate that the proposed point cloud registration method achieves state‐of‐the‐art performance.

Use of modern three-dimensional imaging models to guide surgical planning for local control of pediatric extracranial solid tumors.

In complex pediatric surgical oncology, surgical planning is contingent upon data gathered from preoperative imaging. Three-dimensional (3D) modeling and printing has been shown to be beneficial for adult presurgical planning, though pediatric literature is less robust. The study reviews our institutional experience with the use of 3D image segmentation and printed models in approaching resection of extracranial solid tumors in children. This is a single institutional series from 2021 to 2023. Models were based on computed tomography and magnetic resonance imaging studies, optimized for 3D imaging. The feasibility and creation of the models is reviewed, including specific techniques, software, and printing materials from our institution. Clinical implications for surgical planning are also described, along with detailed preoperative and intraoperative images. 3D modeling and printing was performed for four pediatric patients diagnosed with extracranial solid tumors. Diagnoses included Ewing sarcoma, hepatoblastoma, synovial sarcoma, and osteosarcoma. No intraoperative complications or discrepancies with the preoperative 3D-printed model were noted. No evidence of local recurrence was identified in any patient thus far. Our institutional series demonstrates a wide spectrum of clinical application for 3D modeling and printing technology within pediatric surgical oncology. This technology may aid in surgical planning for both resection and reconstruction, can be applied to a diverse breadth of diagnoses, and may potentially augment patient and/or family education about their condition.

Application of 3d Models in Preoperative Planning of Tibial Plateau Fractures: Can We Expect Changes?

Application of 3d Models in Preoperative Planning of Tibial Plateau Fractures: Can We Expect Changes?

Research on prosthesis customization with 3D modeling and printing technology

With the development of science and technology and the maturity of technology, the application of 3D printing technology has developed from the art to the clinical medical treatment. Nowadays, the research and development and production of personalized customized orthopedic medical devices are possible, and the production line and supply chain of customized prostheses are constantly improving. The research on 3D printing and prosthesis customization technology is at the forefront of science. This article uses the method of literature review, reading, quoting, and summarizing several domestic and foreign professional experimental records and opinions, focusing on the history of 3D modeling and printing technology, the application method of this technology and the current clinical application of 3D modeling and printing technology. This paper puts forward reflection on the current shortcomings of the technology and my thinking and suggestions for future research. The conclusion of this paper is that 3D modeling and printing technology has played a great role in medical treatment, but there are still shortcomings in terms of cost and materials.

Tumor Organoids: The Era of Personalized Medicine.

The strategies of future medicine are aimed to modernize and integrate quality approaches including early molecular-genetic profiling, identification of new therapeutic targets and adapting design for clinical trials, personalized drug screening (PDS) to help predict and individualize patient treatment regimens. In the past decade, organoid models have emerged as an innovative in vitro platform with the potential to realize the concept of patient-centered medicine. Organoids are spatially restricted three-dimensional clusters of cells ex vivo that self-organize into complex functional structures through genetically programmed determination, which is crucial for reconstructing the architecture of the primary tissue and organs. Currently, there are several strategies to create three-dimensional (3D) tumor systems using (i) surgically resected patient tissue (PDTOs, patient-derived tumor organoids) or (ii) single tumor cells circulating in the patient's blood. Successful application of 3D tumor models obtained by co-culturing autologous tumor organoids (PDTOs) and peripheral blood lymphocytes have been demonstrated in a number of studies. Such models simulate a 3D tumor architecture in vivo and contain all cell types characteristic of this tissue, including immune system cells and stem cells. Components of the tumor microenvironment, such as fibroblasts and immune system cells, affect tumor growth and its drug resistance. In this review, we analyzed the evolution of tumor models from two-dimensional (2D) cell cultures and laboratory animals to 3D tissue-specific tumor organoids, their significance in identifying mechanisms of antitumor response and drug resistance, and use of these models in drug screening and development of precision methods in cancer treatment.

Onset and Evolution of Solar Flares: Application of 2D and 3D Models of Magnetic Reconnection

Contemporary multi-wavelength observations have revealed various important features during solar flares. On one hand, these observations support the two-dimensional (2D) “standard flare model,” while on other hand, they also call for exploration of three-dimensional (3D) magnetic field topologies involved in flares. Traditionally, the formation of parallel ribbons on both sides of the polarity inversion line (PIL) and associated overlying loop arcades have been recognized as the most prominent features of eruptive flares, forming the basis for the development of the standard model that provides a 2D description of flare-associated phenomena. However, the actual flare occurs within a more complicated 3D magnetic structure. Thus, despite its general applicability, the standard model has limited or no scope in explaining some features that exclusively require a 3D description. In this context, the observations of “circular ribbon flares” stand out, where one of the ribbons presents an almost fully closed quasi-circular or quasi-ellipsoidal shape, providing evidence of the involvement of a typical fan-spine magnetic configuration. In this article, we discuss observational features vis-à-vis theoretical understanding of solar flares in view of 2D and 3D models of magnetic reconnection. We highlight a few complex cases of circular ribbon flares exhibiting parallel ribbons, a coronal jet, and/or an erupting magnetic flux rope. Exploring various 3D topologies also enables us to probe similarities between the circumstances that govern the onset of jets, confined flares and CME-producing eruptive flares.

Advances in screening hyperthermic nanomedicines in 3D tumor models.

Hyperthermic nanomedicines are particularly relevant for tackling human cancer, providing a valuable alternative to conventional therapeutics. The early-stage preclinical performance evaluation of such anti-cancer treatments is conventionally performed in flat 2D cell cultures that do not mimic the volumetric heat transfer occurring in human tumors. Recently, improvements in bioengineered 3D in vitro models have unlocked the opportunity to recapitulate major tumor microenvironment hallmarks and generate highly informative readouts that can contribute to accelerating the discovery and validation of efficient hyperthermic treatments. Leveraging on this, herein we aim to showcase the potential of engineered physiomimetic 3D tumor models for evaluating the preclinical efficacy of hyperthermic nanomedicines, featuring the main advantages and design considerations under diverse testing scenarios. The most recent applications of 3D tumor models for screening photo- and/or magnetic nanomedicines will be discussed, either as standalone systems or in combinatorial approaches with other anti-cancer therapeutics. We envision that breakthroughs toward developing multi-functional 3D platforms for hyperthermia onset and follow-up will contribute to a more expedited discovery of top-performing hyperthermic therapies in a preclinical setting before their in vivo screening.

Система обучения программированию и выбор микроконтроллеров для управления электроприводами

Ability of university graduates to design electric drives (ED) implies that they have knowledge and skills to develop software for microcontrollers (MC) used in modern electric drive control systems (ED CS). Studies on this topic touch upon the issues of particular training courses or teaching methods, and laboratory benches mean only debug boards. Often, education process is designed on a piecemeal basis. A systematic approach is required to teach students programming of microcontrollers of ED CS. In the context of restrictions of manufacturers from the USA, Japan and Europe, the selection of microcontroller for training and developing the ED CS is also topical. When developing the interrelated training courses, the authors have used 20 years of experience of design of ED CS. Product design software packages and metalworking technologies have been used as tools to develop a specialized laboratory bench. The method of comparative analysis is used when selecting microcontrollers. A multi-level (3-stage) model of interrelated training courses to teach students programming MC of ED CS is described. The evolution of the contents of training courses is shown. The author-developed bench is presented. It includes the debug board, measuring (multimeter, oscilloscope) and debugging (interface converters) equipment placed on a special unit. A review is given, an analysis of studies on these issues is carried out, and recommendations to select MC of ED CS in the current situation are given. Implemented at the department, a systematic approach to teach students programming MC of ED CS gives them the qualifications necessary to independently perform tasks during the design of modern ED CS. The developed laboratory bench provides convenient and safety work with all debugging and measuring equipment used in the educational process. An overview and recommendations on the selection of MC of domestic and Chinese manufacturers will be useful for the developers of the electrical drive control systems.

Tumor Organoid as a Drug Screening Platform for Cancer Research.

A number of studies have been conducted on the application of 3D models for drug discovery, drug sensitivity assessment, and drug toxicity. Most of these studies focused on disease modelling and attempted to control cellular differentiation, heterogeneity, and key physiological features to mimic organ reconstitution so that researchers could achieve an accurate response in drug evaluation. Recently, organoids have been used by various scientists due to their highly organotypic structure, which facilitates the translation from basic research to the clinic, especially in cancer research. With this tool, researchers can perform high-throughput analyses of compounds and determine the exact effect on patients based on their genetic variations, as well as develop personalized and combination therapies. Although there is a lack of standardization in organoid culture, patientderived organoids (PDOs) have become widely established and used for drug testing. In this review, we have discussed recent advances in the application of organoids and tumoroids not only in cancer research for drug screening but also in clinical trials to demonstrate the potential of organoids in translational medicine.

Development and Application of 3D Modeling in Game

The development and progress of computer graphics and 3D modeling technology play an important role in the development of 3D game animation. Three-dimensional modeling technology combines artistic design and computer technology perfectly with a real sense of depth, so it has been widely used in the game industry. This paper introduces the development process of 3D modeling technology and the application of 3D modeling technology in games. At the same time, it gives suggestions on the problems existing in the application of 3D modeling technology in games, as well as researches and looks forward to the development trend of 3D modeling technology.

Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development.

The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) Workshop on 3D Tissue Models for Antiviral Drug Development, held virtually on 7-8 June 2022, provided comprehensive coverage of critical concepts intended to help scientists establish robust, reproducible, and scalable 3D tissue models to study viruses with pandemic potential. This workshop was organized by NCATS, the National Institute of Allergy and Infectious Diseases, and the Bill and Melinda Gates Foundation. During the workshop, scientific experts from academia, industry, and government provided an overview of 3D tissue models' utility and limitations, use of existing 3D tissue models for antiviral drug development, practical advice, best practices, and case studies about the application of available 3D tissue models to infectious disease modeling. This report includes a summary of each workshop session as well as a discussion of perspectives and challenges related to the use of 3D tissues in antiviral drug discovery.

Retracted: Application of Realistic 3D Model in Building Prefabricated Nanomaterial Structure.

[This retracts the article DOI: 10.1155/2022/1726948.].

Cancer 3D Models for Metallodrug Preclinical Testing.

Despite being standard tools in research, the application of cellular and animal models in drug development is hindered by several limitations, such as limited translational significance, animal ethics, and inter-species physiological differences. In this regard, 3D cellular models can be presented as a step forward in biomedical research, allowing for mimicking tissue complexity more accurately than traditional 2D models, while also contributing to reducing the use of animal models. In cancer research, 3D models have the potential to replicate the tumor microenvironment, which is a key modulator of cancer cell behavior and drug response. These features make cancer 3D models prime tools for the preclinical study of anti-tumoral drugs, especially considering that there is still a need to develop effective anti-cancer drugs with high selectivity, minimal toxicity, and reduced side effects. Metallodrugs, especially transition-metal-based complexes, have been extensively studied for their therapeutic potential in cancer therapy due to their distinctive properties; however, despite the benefits of 3D models, their application in metallodrug testing is currently limited. Thus, this article reviews some of the most common types of 3D models in cancer research, as well as the application of 3D models in metallodrug preclinical studies.