In this paper, a newly designed wireless sensing network platform for structural monitoring applications is presented and the results of a validation test performed in the authors' laboratory are reported. The main features offered by the proposed wireless platform are the capability of real-time and multi-channel data transmission, a high compatibility to different types of sensors, a highly efficient power-supply, and low-cost. Instead of adopting the most commonly used commercial wireless modems, the wireless communication is pursued by implementing an optimized and customized solution based on a recent System on Chip wireless transceiver. The Frequency Division Multiplexing method is exploited to ensure the real-time feature of the multi-channel data transmission. A simple and practical point-to-point topology is pursued. The usage of switching regulators which feature low quiescent current, highly efficient power conversion, the adjustable output voltage, and the high output power make this platform suitable for both low-power and non low-power structural monitoring applications involving different types of sensors. In order to validate the prototyped platform, a laboratory test is performed. The measurements of the acceleration response of a simple 3-storey structure mounted on a shaking table are acquired from both a wired DAQ system and the developed wireless platform. The data comparison enables to validate the efficacy of the real-time, multi-channel wireless transmission.