Objective To explore the application effect of nursing intervention to prevent postpartum hemorrhage in natural childbirth. Methods A total of 86 women who underwent natural childbirth in the hospital from December 2016 to November 2017 were selected as research objects.According to the random number table method, the patients were divided into the control group and the observation group, 43 cases of each group.The control group was given routine nursing.The observation group was added with comprehensive nursing intervention on the basis of the control group.A comprehensive evaluation was conducted on the condition of postpartum hemorrhage, postpartum adverse reactions, Self-Rating Anxiety Scale(SAS), Self-Rating Depression Scale(SDS)before and after nursing care in the two groups. Results The amount of bleeding at delivery, 2 hours postpartum and 12 hours postpartum in the observation group were significantly lower than those in the control group, and the differences were statistically significant(P<0.05). After nursing, 2 cases of maternal adverse reactions occurred in the observation group, accounting for 4.65%, which was significantly lower than that of the control group 25.58%, and the difference was statistically significant (P<0.05). The scores of SAS and SDS in the observation group were compared with those of the control group, and the differences were statistically significant (P<0.05). Conclusions Nursing intervention in the natural delivery of maternal application can reduce the amount of blood loss, relieve maternal negative psychology, reduce the incidence of adverse reactions.It is worth promoting the application. Key words: Nursing intervention; Postpartum hemorrhage; Natural childbirth; Adverse reaction; Application effect