Apparent Molar Volume Of Transfer Research Articles

The impact of thermophysical properties on eflornithine drug solute in acetone and ethyl acetate solvent interactions at varying concentrations and temperatures

The study was conducted on the impact of thermophysical properties on eflornithine drug solute–solvent interactions in aqueous ethyl acetate and acetone at different concentrations and temperatures. The aim of this study is to enhance the understanding of eflornithine’s behavior in different solvents, which is crucial for its effective use in pharmaceutical applications. The density, molar volume, viscometric, and conductometric characteristics of the eflornithine drug solutions (0.025, 0.05, 0.075, 0.1, and 0.125 mol/kg) in acetone and 25% (v/v) aqueous ethyl acetate were measured within a temperature range of 298.15 K–318.15 K. Based on the determined density parameters, the following parameters were assessed: viscosity (η), equivalent molar conductance, limiting apparent molar volume (V0φ), apparent molar volume of transfer (V0φtr), and apparent molar volume (Vφ). The Masson empirical relationship and the viscosity-to-Jones-Dole (JD) equation were used to evaluate the partial molar volume (Vφ), experimental slope (SV), viscosity, and density data. Temperature and concentration were used to determine each parameter. For each set of dilutions, conductometric studies were conducted in both study solvents. The gathered data was analyzed in order to evaluate the ion–solvent interactions. The Walden product Λomηo’s positive temperature coefficient values indicate that the drug eflornithine functions as a structural modifier in acetone and aqueous acetyl acetate systems. The structure-making and breaking characteristics of the polar solvents acetone and ethyl acetate were identified.

Volumetric and acoustic studies of L-Citrulline in aqueous Urea and Dextrose solutions at different temperatures

Density (ρ) and speed of sound (u) values of L-Citrulline in aqueous solution, 0.06 mol·kg−1 aqueous Urea and aqueous 0.06 mol·kg−1 Dextrose solutions have been measured at T = (288.15, 293.15, 298.15, 303.15, 308.15, 313.15 and 318.15) K within the concentration range of (0.02 to 0.2) mol·kg−1.These measurements have been performed to evaluate some important parameters, viz, apparent molar volume of solute (Vϕ), limiting apparent molar volume of solute (Vϕ0), limiting apparent molar volume of transfer (ΔtrVϕ0), limiting apparent molar expansivity(Eϕ0), thermal expansion coefficient (α*), Hepler's constant (∂2Vϕ0∂T2), isentropic compressibility (κs), apparent molar compressibility (Ks,ϕ), limiting apparent molar compressibility (Ks,ϕ0), limiting apparent molar isentropic compressibility of transfer (ΔtrKs,ϕ0)and hydration number(ηH) . The results have been interpreted in terms of different interactions taking place in aqueous solutions.

Effect of trisodium citrate dihydrate on thermophysical properties of saccharides in aqueous media at different temperatures: Volumetric and acoustic properties

From the measurements of density, (ρ) and speed of sound, (u), the intermolecular interactions of D-maltose monohydrate and D-lactose monohydrate with trisodium citrate (TSC) have been explored in aqueous medium at temperatures, T = (293.15–313.15) K, pressure p = 0.1 MPa. From the experimental density measurements, apparent molar volume (VΦ), limiting apparent molar volume (VoΦ) and limiting apparent molar volume of transfer (VoΦ,tr) have been determined for various solutions of maltose and lactose in aqueous TSC. In addition, using experimental speed of sound data, apparent molar isentropic compressibility (KΦ,s), limiting apparent molar isentropic compressibility (KoΦ,s) and partial molar isentropic compression of transfer (KoΦ,s,tr) have been calculated.Further, apparent molar expansibility (EoΦ), Hepler's constant values(∂EoΦ∂T)Pand hydration number (nH)have been assessed to contribute the interpretations received from the acoustic and analysis. The assessed outcomes were construed in terms of diverse intermolecular interactions present in the ternary systems (saccharides+ water + TSC) through a co-sphere overlap model. From the Hepler's constant structure breaking nature of the solute have been confirmed.

Volumetric and acoustic studies of aqueous l-arginine·HCl and l-proline in electrolytic and non-electrolytic solutions at various temperatures

Densities and speed of sound of l-arginine hydrochloride and l-proline within the concentration range (0.03–0.2) mol.kg−1 in water and in aqueous NaCl and Urea are determined between temperatures 288.15 K and 318.15 K and at one atmospheric pressure. Densities and speeds of sound have been used to calculate apparent molar volume of solute (Vφ), isentropic compressibility of solution (κS), apparent molar isentropic compressibility (KS,φ) of solute, limiting apparent molar volume (Vφ0), limiting apparent molar volume of transfer (ΔtrVφ0), limiting apparent molar expansibility (Eφ0), limiting apparent molar isentropic compressibility (KS,φ0) and limiting apparent molar isentropic compressibility of transfer (ΔtrKS,φ0). These results are then interpreted in terms of intermolecular interactions. The concentration dependencies of the calculated quantities, their limiting values and temperature characteristics are discussed in terms of solute - solvent and solute - solute interactions at experimental conditions.

Solute–solvent interactions of ibuprofen in the aqueous solutions of 1–propanol: Volumetric, acoustic and viscometric study

Ternary system contains ibuprofen + water +1–propanol in the certain composition have been reported as forming two phases systems. Therefore solute–solvent and solute–solute interactions are necessary for a fundamental understanding of the phase equilibrium in this ternary system. In this work solute–solvent and solute–solute interactions were studied via volumetric, acoustic and viscometric methods. The experimental densities, speed of sounds and viscosities of ibuprofen in mixtures of water +1–propanol with different cosolvent proportions (w1-pro = 1.000, w1-pro = 0.950, w1-pro = 0.900, w1-pro = 0.850, w1-pro = 0.800) were measured at temperatures T = 288.15, 298.15 and 308.15 K. The apparent molar volume (Vϕ), apparent molar volume at infinite dilution (Vϕo), apparent molar volume of transfer (ΔtrVϕo), apparent molar isentropic compressibility (κϕ), apparent molar isentropic compressibility at infinite dilution (κϕo) and viscosity B-coefficient were calculated using the experimental data. The obtained apparent molar volume, apparent molar isentropic compressibility at infinite dilution and viscosity B–coefficient are explained in terms of solute–solvent and solute–solute interactions. The obtained results reveal that solute–solvent interactions decrease with increasing temperature. Also, solute–solvent interactions decrease with decreasing weight fraction of 1–propanol. This behavior may be due to preferential solvation of ibuprofen with 1–propanol.

Volumetric, acoustic and viscometric studies of solute-solute and solute-solvent interactions of glycyl-glycyl-glycine in aqueous tartaric acid at different temperatures

In this investigation, thermophysical properties like density, speed of sound and viscosity of solutions of glycyl-glycyl-glycine (0.05–0.40) mol·kg−1 were studied with water and aqueous solvent (tartaric acid). The solutions were experimentally calculated with in temperature range of (298.15 and 318.15) K and at pressure (0.1 MPa). The obtained experimental outcomes were further taken to compute the parameters like apparent molar volume, limiting apparent molar volumes, limiting apparent molar volumes of transfer, the hydration number from volumetric data and properties like apparent molar isentropic compression, limiting apparent molar isentropic compression, limiting apparent molar isentropic compression of transfer and the hydration number from acoustic data of the studied solutions. The experimental viscosity values were used in the Jones-Dole equation to obtain viscosity coefficients A and B. The computed activation parameters of the studied system were explained on the lines of transition state theory. These experimental and computed parameters and further, their alterations with molal concentration and temperature were discussed from the point of view of ionic-hydrophilic, hydrophilic-hydrophilic and hydrophilic-hydrophobic operational in the system.

Determination of densities, apparent molar volume and apparent molar volume of transfer of some R4NI salt solutions in NMF-DMSO mixtures using magnetic float densitometer and then to study of ionic Interaction at 303.15 K

Binary solvent mixtures of different (%) compositions have been prepared at 303.15 K using tetra alkyl ammonium iodides (R 4 NI) of 0.02 M to 0.14 M to investigate inter ionic interaction, ion-ion and ion solvent interactions in NMF-DMSO solvent mixture containing large cations of tetra alkyl ammonium iodides (R 4 NI). The densities (ρ 0 ) of binary solvent mixtures and salt solutions have been measured by magnetic float densitometer. The apparent molar volume at infinite dilution ф v 0 , in the solvent mixtures, have been utilized to estimate the apparent molar volumes of transfer ∆ф v 0 (tr), for various tetra alkyl ammonium iodide salts (R 4 NI) from NMF-DMSO mixtures. The observed trend and variations of dielectric constant and density with different (%) composition of NMF – DMSO provide useful information about the structural interactions.

How the presence of ATP affect caffeine hydration and self-aggregation?

Based on data analyzed from volumetric, viscosimetric measurements and computational simulations, caffeine hydration and aggregation properties in aqueous solutions were compared with caffeine properties in the presence of ATP. The experimental values of the apparent molar volume (Vϕ), apparent molar volume at infinite dilution (Vϕo), Masson's experimental slope (Sv), the apparent molar volume of transfer (ΔtrVϕo), limiting apparent molar expansibility, (Eϕo), hydration number, viscosity B coefficient, thermodynamics parameters of viscous flow were calculated in the temperature range from T = (283.15 to 313.15) K. For the additional investigation of the caffeine hydration properties, the molecular dynamics (MD) simulations, the radial distributive functions (RDFs) and spatial distribution functions (SDFs) were performed. Reduced caffeine hydration and pronounced self-aggregation in the ATP presence are linked to its dehydration effect on caffeine molecules. These results point out the ATP negative effects on caffeine, due to undesirable process of active molecule self-aggregation leading to the reduce bioavailability in the biological systems.

Investigation of the effect of temperature on aggregation behaviour and thermodynamic properties of Ornithine monohydrochloride in aqueous and aqueous dextrose and urea solutions

In this communication for the first time, we report the density ρ and speed of sound u of aqueous solution of Ornithine monohydrochloride (Ornithine·HCl) and Ornithine monohydrochloride (Ornithine·HCl) in aqueous 0.06 mol·kg−1 urea and aqueous 0.06 mol·kg−1 dextrose at T = (288.15, 293.15, 298.15, 303.15, 308.15, 313.15 and 318.15) K within the concentration range of (0.02 to 0.2) mol·kg−1. From the experimental data of density (ρ) and speed of sound (u) the various derived parameters such as apparent molar volume of solute (Vϕ) limiting apparent molar volume of solute Vϕ0, limiting apparent molar volume of transfer (ΔtrVϕ0), limiting apparent molar expansivity Eϕ0, thermal expansion coefficient (α*), second derivative of limiting apparent molar volume ∂2Vϕ0/∂T2, isentropic compressibility κs, apparent molar compression (Ks,ϕ), limiting apparent molar compression of solute KS,ϕ0, apparent molar isentropic compression of transfer ΔtrKS,ϕ0 and hydration number (nH) have been calculated.

Apparent molar volume, isentropic compressibilities, viscosity B-coefficients and activation parameters of thiamine hydrochloride in aqueous solutions of saccharides at different temperatures

In this paper, volumetric, ultrasonic and viscometric analysis of thiamine hydrochloride in aqueous and mixed aqueous solutions of saccharides such as (0.1 mol kg−1 D-(-)-fructose, 0.1 mol kg−1 D-(+)-maltose and 0.1 mol kg−1 sucrose) over the temperature range (293.15–318.15) K and pressure, p = 101.3 kPa have been carried out. These have assisted in understanding the solute–solute, solute–solvent and solute–solvent interactions prevailing in the considered system. From the density data, the parameters like the apparent molar volume (Vϕ), limiting apparent molar volume (V0ϕ) and limiting apparent molar volume of transfer (ΔtrV0ϕ) have been computed. From the ultrasonic studies, the apparent molar isentropic compression (Kϕ,s), limiting apparent molar isentropic compression(K0ϕ,s) and limiting apparent molar isentropic compression of transfer (ΔtrK0ϕ,s) have been assessed. The Kϕ,s values are negative and that of ΔtrK0ϕ,s values are positive for thiamine hydrochloride in mixed aqueous 0.1 mol kg−1 systems of fructose/maltose/sucrose. From viscosity data, Falkenhagen A-coefficients and viscosity B-coefficients have been evaluated by employing the Jones-Dole equation. The Hepler’s constant (∂2V0ϕ/∂T2), limiting apparent molar expansibility (E0ϕ), thermal expansion coefficient (α), solvation number (Sn), activation parameters related to viscous flow (Δμ01, Δμ02, TΔS02 and ΔH02) etc. have also been estimated. By examining these results, we procured that the thiamine hydrochloride behaves as a structure breaker in aqueous and mixed aqueous solutions of saccharides.

Volumetric and acoustic methods for investigating molecular interactions of antibiotic drug doxycycline hyclate in water and in aqueous solution of sodium chloride and potassium chloride at different temperatures (293.15–313.15) K

The solution properties of antibiotic drug Doxycycline Hyclate (DH) were investigated to explore molecular interactions with aqueous NaCl and KCl solutions around their physiological cell concentrations at different temperatures. Apparent molar properties i.e. apparent molar volume (ΦV) and apparent molar isentropic compression (ΦK) for DH within the concentration range (0.0020–0.0140) mol·kg−1 in water and in (0.005, 0.012 and 0.140) mol·kg−1 aqueous NaCl and KCl solutions were calculated from experimentally measured densities (ρ) and Ultrasonic speed (u) values at T = (293.15, 298.15, 303.15, 308.15 and 313.15) K temperatures and at P = 0.1 MPa pressure. The data of apparent molar properties were utilised to obtain various derived parameters such as limiting apparent molar volume, (Φvo), limiting apparent molar isentropic compression, (ΦKo), limiting apparent molar volume of transfer, ∆ΦVO, limiting apparent molar isentropic compression of transfer, ∆ΦKO, limiting apparent molar expansibility, ΦEo, and thermal expansion coefficient, α. The structure making/breaking ability of DH in aqueous NaCl and KCl were determined on the basis of Hepler's Equation i.e. on the basis of sign of (d2ΦVOdT2)P. The results obtained from all these thermodynamic parameters were discussed in terms of solute-solute and solute-solvent interactions in these systems. The volumetric, compressibility and acoustic data suggests the existence of strong solute-solvent interactions in the studied systems.

Diverse Interactions of N-Methyl Glycine in Aqueous Paracetamol Solution with the Manifestation of Solvation Consequences

The apparent molar volume (ϕV) and viscosity B-coefficient of N-methyl glycine of 0.01 M, 0.02 M and 0.03 M aqueous solutions have been estimated in presence of paracetamol at three temperatures namely 298.15 K, 303.15 K and 308.15 K from physicochemical study such as density (ρ) and viscosity (η) and refractive index measurements and 1 H NMR spectroscopy. The volumetric study was employed to evaluate limiting apparent molar volumes (ϕ V 0 ) and experimental slopes (S V *) by using Masson equation for explaining solute–solvent and solute–solute interactions, respectively. The nature of group interactions between the solute, solvent and co-solute have been examined from limiting apparent molar volumes of transfer (Δϕ V 0 ) values. The viscosity data were employed to determine viscosity A and B coefficients from Jones–Dole equation and the resulting parameters were used to examine the solute–solute and solute–solvent interactions in the solutions. Molar refraction values calculated from refractive indices by applying Lorentz–Lorenz equation were used to depict the intermolecular interactions between N-methyl glycine and paracetamol in their aqueous solution. However, the 1 H NMR spectroscopy supports the existence of diverse interactions concretely.

The Study of Intermolecular Interactions for dl-Alanine and Glycine in Aqueous l(+)-Arabinose Solutions at Different Temperatures and Ambient Pressure, Using the Volumetric Approach

Density measurements are used to calculate the apparent molar volumes Vφ, limiting apparent molar volumes $$V_{\varphi }^{0}$$ , limiting apparent molar volumes of transfer, $$\Delta_{\text{t}} V_{\varphi }^{0}$$ , limiting apparent molar expansibilities, $$E_{\varphi }^{0}$$ , and hydration numbers nH, for dl-alanine and glycine in aqueous solutions of l(+)-arabinose at T = 293.15 to 313.15 K. To obtain the limiting apparent molar volume, the Vφ values are extrapolated to zero molality using the linear form of the Redlich–Meyer equation. Also, the limiting apparent molar volumes of transfer, $$\Delta_{\text{t}} V_{\varphi }^{0}$$ , for the amino acids, from water to aqueous l(+)-arabinose solutions, are calculated from the $$V_{\varphi }^{0}$$ values. The limiting apparent molar expansibility, $$E_{\varphi }^{0}$$ , values have been obtained from the first derivative of limiting apparent molar volumes with respect to temperature. Also the hydration number, nH, for both amino acids in the ternary solutions are estimated. Possible solute–solvent interactions in the studied ternary systems are discussed.

Volumetric and viscometric study of the ternary (dl-alanine/+d(−)-fructose + water) solution at different temperatures and atmospheric pressure

Abstract The density and viscosity measurements have been performed for the ternary ( dl -alanine/+ d (−)-fructose + water) system at T = 293.15, 298.15, 303.15, 308.15, 313.15 K and ambient pressure. By using the obtained experimental densities, the apparent molar volume, limiting partial molar volumes, limiting apparent molar volume of transfer, limiting apparent molar expansibility and hydration number are calculated for dl -alanine in the aqueous d (−)-fructose solution. Redlich-Mayer type equation has been applied for correlating the apparent molar volume values in dilute region. The obtained viscosity data in the whole concentration range were correlated to the Jones-Dole semi-empirical equation. The viscosity B-coefficients were obtained by fitting viscosity data to Jones-Dole equation. It is well established that the viscosity B-coefficient is a measure of solute–solvent interactions, and is directly dependent on the size, shape and charge of the solute molecules. With helping the obtained results from the volumetric and viscometric measurements, we are able to describe the nature of possible interactions in the studied ternary system.

Thermo-physical properties of l-Alanine/l-Valine in aqueous solutions of non steroid anti inflammatory drug dolonex at different temperatures: Volumetric and acoustic approach

Abstract Thermodynamic properties of l -Alanine and l -Valine in aqueous solutions of drug dolonex, have been investigated by combination of volumetric and acoustic methods at various temperatures (293.15, 298.15, 303.15, 308.15 and 313.15) K and at atmospheric pressure. The experimental data is further used to calculate limiting apparent molar volume, VoΦ, limiting apparent molar volume of transfer, VoΦ,tr, limiting molar isentropic compression, KoΦ,S and limiting apparent molar isentropic compression of transfer, KoΦ,S,tr. Furthermore, apparent molar expansivity, EoΦ, Hepler constant values, ∂ E Φ o ∂ T P , coefficient of thermal expansion, α and hydration number, nH were also calculated. The obtained results were used to interpret solute-solute and solute-solvent interactions in these systems. The volumetric and compressibility data suggests dominance of hydrophilic-hydrophilic interactions in these systems.

Structure-making behaviour of L-arginine in aqueous solution of drug ketorolac tromethamine: volumetric, compressibility and viscometric studies

ABSTRACTIn this work, density ρ, speed of sound u and viscosity η, were measured for L-arginine in aqueous ketorolac tromethamine solutions at various temperatures (293.15, 298.15, 303.15, 308.15 and 313.15 K) and at atmospheric pressure. Apparent molar volume VΦ, limiting apparent molar volume V°Φ, limiting apparent molar volume of transfer V°Φ,tr, limiting molar expansivity E°Φ, Hepler’s constant and hydration number nH were obtained using density data. Apparent molar isentropic compression KΦ,S, limiting apparent molar isentropic compression K°Φ,S, limiting apparent molar isentropic compression of transfer K°Φ,S,tr and hydration number nH were obtained using speed of sound data. Jones–Dole coefficient-B B, viscosity B-coefficients of transfer Btr, variation of B with temperature (), free energy of activation of viscous flow per mole of solvent Δμ°#2 and per mole of solute Δμ°#1 were obtained from viscosity data. The obtained results are discussed in terms of solute–solvent interactions in these systems.

Study of intermolecular interactions in the ternary (1-Ethyl-3-methylimidazolium hydrogen sulfate [Emim][HSO4] / 1-Butyl-3-methylimidazolium tetrafluoroborate [Bmim][BF4] + D(−)fructose + water) systems using the volumetric properties at different temperatures and ambient pressure

In continuation of our previous works, using the density measurement, we studied some important volumetric properties such as: apparent molar volumes, standard partial molar volumes, limiting apparent molar volumes of transfer, and limiting apparent molar expansibility for the ternary (ionic liquids 1-Ethyl-3-methylimidazolium hydrogen sulfate [Emim][HSO4]/1-Butyl-3-methylimidazolium tetrafluoroborate [Bmim][BF4]+D(−)fructose+water) at T=(293.15 to 313.15) K. By using the standard partial molar volumes and limiting apparent molar volumes of transfer, the nature of possible interactions in studied solutions are considered. Results demonstrated that for both studied ionic liquids, the Vφ values are increased with rising concentration of ionic liquids and temperature. Also by applying the first derivative of limiting apparent molar expansibility with respect to temperature, the structure maker ability of studied ionic liquids in aqueous D(−)fructose solutions are confirmed.

Volumetric, acoustic and viscometric studies of l-histidine in aqueous solutions of non-steroid anti-inflammatory drug ketorolac tromethamine at different temperatures

In this investigation density, speed of sound and viscosity of l-histidine (0.015–0.135) molkg−1 in aqueous ketorolac tromethamine solutions (0.1–0.7) molkg−1 at various temperatures (293.15, 298.15, 303.15, 308.15 and 308.15) K and at atmospheric pressure were studied. These data were further used to calculate apparent molar volume, VΦ, limiting apparent molar volume, V°Φ, limiting apparent molar volume of transfer, V°Φ,tr, apparent molar isentropic compression, KΦ,S, limiting molar isentropic compression, K°Φ,S, limiting apparent molar isentropic compression of transfer, K°Φ,S,tr, hydration number, nH, Jones-Dole coefficient-B, B, viscosity B-coefficients of transfer, Btr and the activation parameters, ∆μ°#1 and ∆μ°#2. The results obtained from all these thermodynamic parameters were discussed in terms of solute-solute interactions and solute-solvent interactions on the basis of co-sphere overlap model and the transition state theory.

Structure making behaviour of L-histidine in aqueous solutions of ampicillin sodium at different temperatures: Using physicochemical methods

Experimentally determined values of density (ρ), speed of sound (u) and viscosity (η) have been used to investigate solute-solvent interactions of L-histidine in aqueous ampicillin sodium (an antibacterial drug) solutions at different concentrations (0.035, 0.055, 0.075 and 0.095)molkg−1, over a wide range of temperatures (293.15, 298.15, 303.15, 308.15 and 313.15)K and at atmospheric pressure. The experimentally determined density (ρ) data has been used to obtain various parameters, for instance: apparent molar volume (VΦ), limiting apparent molar volume (VoΦ), limiting apparent molar volume of transfer (VoΦ,tr), limiting molar expansivity (EoΦ) and hydration number (nH). The speed of sound (u) data helps to enumerate apparent molar isentropic compression (KΦ,S), limiting molar isentropic compression (KoΦ,S), limiting apparent molar isentropic compression of transfer (KoΦ,S,tr) and hydration number (nH) i.e., the number of water molecules hydrated to the amino acid. Relative viscosity (ηr), Jones-Dole coefficient-B (B) and viscosity B-coefficients of transfer (Btr) were calculated from viscosity (η) data. The results obtained from this data, showed the existence of physico-chemical interactions, (i.e., hydrophilic-ionic and hydrophilic-hydrophilic) in ampicillin sodium L-histidine solutions. The structure making behaviour of L-histidine in aqueous ampicillin sodium solution was studied in terms of Hepler’s constant ∂2VΦo∂T2P, coefficient of thermal expansion (α) and temperature derivative of B-coefficient (dB/dT).

The study of solute–solvent interactions in the ternary {Amino acid (Glycine or l-serine) + ionic liquid (1-butyl-3-methylimidazolium tetra fluoroborate [Bmim][BF4]) + H2O} system at different temperatures and ambient pressure: Volumetric study

Abstract The solute–solvent interactions in the studied aqueous ternary systems containing some amino acids (Glycine or l -serine) and ionic liquid (1-butyl-3-methylimidazolium tetra fluoroborate [Bmim][BF4]) are studied by using the volumetric properties data. These properties contains: apparent molar volumes, standard partial molar volumes, limiting partial molar volumes of transfer, apparent molar expansibility and hydration number. Vφ values were increased when rising concentration of amino acids and also temperature while decreased by increasing concentration of ionic liquid. Apparent molar volumes of transfer, ΔVφ0, for studied amino acids from water to aqueous solutions of ionic liquid (IL) are calculated. The limiting partial molar volumes of transfer ΔtVφ0 values were negative. Results confirmed the dominance of hydrophobic-hydrophobic interactions in both ternary solutions.