API Manufacturing Research Articles

Novel Technique for Filtration Avoidance in Continuous Crystallization

Fouling and clogging of lines in both continuous crystallization and flow chemistry still present a challenge in designing continuous processes. This paper presents a proof of concept for a novel unit operation designed for purification and to eliminate the need for slurry handling in API manufacturing by utilizing a dynamic (falling) film-based solution layer crystallization technique called “filtration-avoidance”. Fenofibrate (with fenofibric acid as an impurity) and acetaminophen (with metacetamol as an impurity) in different solvents were tested as crystallization systems, and the final purities and yields are reported. Sixteen different combinations of materials and process parameters were investigated. The results show significant improvement in the purity of the main compounds and a high yield for the process, which indicates a potential industrial application for a filtration-free continuous separation process, e.g., final purity of 99.4% was achieved from the experiment with a solution of 98% fen...

Studies on the Continuous-Flow Synthesis of Nonpeptidal bis-Tetrahydrofuran Moiety of Darunavir

The use of continuous-flow chemistry has shown to be an important tool in improving API manufacture. In the present paper, we report the use of continuous-flow reactors in the synthesis of the bicyclic side chain of antiretroviral Darunavir.

A Study of Pharmaceuticals in India and Kashmir Aspect

The Indian pharmaceutical industry positions among the top five countries by volume (production) and accounts for about 10% of worldwide production. The industry?s gross revenue has grown from a simple US$ 0.3 bn in 1980 to about US$ 21.73 billion in 2009-10. Stumpy cost of skilled manpower and innovation are some of the major factors taking sides of this growth. According to the Department of Pharmaceuticals, the Indian pharmaceutical industry employs about 340,000 people and an approximate 400,000 doctors and 300,000 chemists. The Indian pharmaceutical industry is disjointed with more than 10,000 manufacturers in the controlled and unplanned segments. The products manufactured by the Indian pharmaceutical industry can be generally classified into bulk drugs (active pharmaceutical ingredients - API) and formulations. Of the total number of pharmaceutical manufacturers, about 77% make formulations, while the remaining 23% make up bulk drugs. Bulk drug is an active constituent with medicinal properties, which acts as fundamental raw material for formulations. Formulations are precise dosage forms of a bulk drug or a mixture of bulk drugs. Drugs are available as syrups, injections, tablets and capsules. Based on the pharmaceutical consumer base, the Indian API manufacturing segment can be alienated into two sectors ? innovative or branded and generic or unbranded. In 2009, the worldwide generic drug market was projected to be US$ 84 billion, of which the US accounted for 42%. India‟s generic drug industry is approximate to be US$ 19 bn and it ranks third globally, contributing about 10% to global pharmaceutical production. Pharmaceutical manufacturing units are mainly concentrated in Maharashtra and Gujarat. These regions hold for about 45% of the total number of pharmaceutical manufacturing units in India. Based on the elevated value plant species, J&K has a huge potential for establishing bio-pharmaceutical industry.

Looking for a partner with a proven track record in API development and manufacturing services?

RETURN TO ISSUEPREVAdvertisementNEXTLooking for a partner with a proven track record in API development and manufacturing services?Cite this: Chem. Eng. News 2013, 91, 44, 35Publication Date (Print):November 4, 2013Publication History Published online31 March 2014Published inissue 4 November 2013https://doi.org/10.1021/cen-09144-ad21Copyright © 2013 Chemical & Engineering NewsArticle Views64Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) SUBJECTS:Manufacturing Get e-Alerts

Looking for a partner with a proven track record in API development and manufacturing services?

RETURN TO ISSUEPREVAdvertisementNEXTLooking for a partner with a proven track record in API development and manufacturing services?Cite this: Chem. Eng. News 2013, 91, 40, 30Publication Date (Print):October 7, 2013Publication History Published online31 March 2014Published inissue 7 October 2013https://doi.org/10.1021/cen-09140-ad20Copyright © 2013 Chemical & Engineering NewsArticle Views71Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) SUBJECTS:Manufacturing Get e-Alerts

Looking for a partner with a proven track record in API development and manufacturing services?

Looking for a partner with a proven track record in API development and manufacturing services?

Looking for a partner with a proven track record in API development and manufacturing services? The facts are in... We deliver!

Looking for a partner with a proven track record in API development and manufacturing services? The facts are in... We deliver!

Looking for a partner with a proven track record in API development and manufacturing services?

Looking for a partner with a proven track record in API development and manufacturing services?

Looking for a partner with a proven track record in API development and manufacturing services?

RETURN TO ISSUEPREVAdvertisementNEXTLooking for a partner with a proven track record in API development and manufacturing services?Cite this: Chem. Eng. News 2013, 91, 21, 47Publication Date (Print):May 27, 2013Publication History Published online31 March 2014Published inissue 27 May 2013https://doi.org/10.1021/cen-09121-ad32Copyright © 2013 Chemical & Engineering NewsArticle Views69Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) SUBJECTS:Manufacturing Get e-Alerts

Looking for a partner with a proven track record in API development and manufacturing services?

Looking for a partner with a proven track record in API development and manufacturing services?

Looking for a partner with a proven track record in API development and manufacturing services?

Looking for a partner with a proven track record in API development and manufacturing services?

Looking for a partner with a proven track record in API development and manufacturing services?

Looking for a partner with a proven track record in API development and manufacturing services?

Looking for a partner with a proven track record in API development and manufacturing services?

RETURN TO ISSUEPREVAdvertisementNEXTLooking for a partner with a proven track record in API development and manufacturing services?Cite this: Chem. Eng. News 2013, 91, 7, 49Publication Date (Print):February 18, 2013Publication History Published online31 March 2014Published inissue 18 February 2013https://doi.org/10.1021/cen-09107-ad22Copyright © 2013 Chemical & Engineering NewsArticle Views14Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) SUBJECTS:Manufacturing Get e-Alerts

Looking for a partner with a proven track record in API development and manufacturing services?

RETURN TO ISSUEPREVAdvertisementNEXTLooking for a partner with a proven track record in API development and manufacturing services?Cite this: Chem. Eng. News 2013, 91, 6, 35Publication Date (Print):February 11, 2013Publication History Published online31 March 2014Published inissue 11 February 2013https://doi.org/10.1021/cen-09106-ad24Copyright © 2013 Chemical & Engineering NewsArticle Views11Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) SUBJECTS:Manufacturing Get e-Alerts

Looking for a partner with a proven track record in API develoment and manufacturing services?

Looking for a partner with a proven track record in API develoment and manufacturing services?

A Scalable Synthesis of CE-157119 HCl Salt, an SRI/5-HT2A Antagonist

A scalable synthesis of CE-157119 HCl salt (1), an SRI/5-HT2A antagonist, was developed via the regioselective SNAr etherification between a phenol and an N-methylamide. This early development route shortened the original 5-step synthesis to three steps, eliminated all chromatography and increased the overall yield from 15% to 34%. The process was implemented for API manufacture from 100-g scale to multikilogram scale.

Looking for a partner with a proven track record in API development and manufacturing services?

Looking for a partner with a proven track record in API development and manufacturing services?

Looking fro a partner with a proven track record in API development and manufacturing services?

Looking fro a partner with a proven track record in API development and manufacturing services?

Looking for a partner with a proven track record in API development and manufacturing services?

RETURN TO ISSUEPREVAdvertisementNEXTLooking for a partner with a proven track record in API development and manufacturing services?Cite this: Chem. Eng. News 2012, 90, 36, 7Publication Date (Print):September 3, 2012Publication History Published online29 March 2013Published inissue 3 September 2012https://doi.org/10.1021/cen-09036-ad05Copyright © 2012 Chemical & Engineering NewsArticle Views10Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (4 MB) SUBJECTS:Manufacturing Get e-Alerts

Looking for a partner witha proven track record in API development and manufacturing services?

Looking for a partner witha proven track record in API development and manufacturing services?