The evolution under alpha-decay radiation of a 241Am doped aluminoborosilicate glass-ceramic was investigated in hot cells DHA-ATALANTE facility in CEA. The cumulative La2O3 - Am2O3 solubility limit was voluntarily exceeded, leading to the formation of apatite-like silicate crystals. The crystals, with a hexagonal-shaped morphology, that is characteristic of apatite crystals, have a composition and a cell parameter close to those expected for an apatite phase of stoichiometric composition Ca2(La,Am)8(SiO4)6O2. Structural and microstructural evolutions under alpha self-irradiation were followed for 8 years by regularly analyzing the crystals and the residual glassy matrix. The evolution of the X-Ray Diffraction (XRD) patterns is the result of a progressive radiation-induced amorphization in apatite crystals. The fully amorphous state is reached at an alpha-decay dose of around 3 × 1018 α/g. Raman analyses suggest a modification of the connectivity of the SiO4 tetrahedra of apatite crystals, with a transition from isolated SiO4 units in the crystalline state to connected SiO4 units in the metamict state. The crystalline-to-amorphous transformation is accompanied by an increase in macroscopic volume (swelling), highlighted by RAMAN imaging. This macroscopic dimensional change is also associated to a decohesion of the crystals from the glassy matrix, observed by Scanning Electron Microscopy (SEM). However, optical and SEM images of the glass-ceramic surface do not reveal any significant cracks in the residual glass under alpha self-irradiation, thus showing a quite good stability of this glass-ceramic material.