Aortic Elastic Properties Research Articles

The role of type 2 diabetes mellitus on hypertensive-related aortic stiffness.

Hypertension is strongly related to arterial stiffness in a cause-effect fashion. Diabetes mellitus is also thought to determine vascular damage, mostly by means of advanced glycosylation end-products (AGEs). Aim of our study was to study the role of type 2 diabetes mellitus (T2DM) as regard ascending aortic elastic properties in hypertensive patients. We prospectively enrolled outpatients with hypertension (n=99) and type 2 diabetes mellitus plus hypertension (n=42) without cardiovascular events. They underwent a transthoracic echocardiography to measure aortic diameters, aortic elastic properties (ie, compliance, distensibility, stiffness index, Peterson's elastic modulus, pulse wave velocity, M-mode strain), tissue Doppler imaging (TDI) to calculate diastolic (E' and A') and systolic (S') velocities, and tissue strain. Multivariable analysis was run to assess the association between T2DM and these variables after correcting for possible confounders (age, sex, body mass index [BMI], dyslipidemia). The two groups did not differ as regards age, sex, BMI, and blood pressure. However, T2DM patients were more likely to be dyslipidemic (43% vs 71%, P=.003). Aortic diameters were similar in the two groups, but the aortic elastic properties significantly more impaired in T2DM group. At multivariable analysis, stiffness index, Peterson's elastic modulus, the TDI waves, and the tissue strain remained associated with the co-presence of T2DM and hypertension. Our data suggest that people suffering from both T2DM and hypertension have more impaired aortic elastic properties than those hypertensive alone. Considering the prognostic role of aortic stiffness, these patients may benefit from a closer follow-up.

Impaired Cardiac Functions and Aortic Elastic Properties in Patients with Severe Vitamin D Deficiency.

Background:The study explored the effect of severe Vitamin D deficiency on cardiac functions and aortic elastic properties determined by echocardiography.Patients and Methods:It included 56 patients with Vitamin D deficiency (Group 1; 16 men, 40 women; mean age 43.1 ± 11.4 years) and 42 healthy individuals with normal Vitamin D levels (Group 2; 11 men, 31 women; mean age 40.0 ± 7.5 years). Calcium, parathormone, alkaline phosphatase, and Vitamin D levels were measured from blood samples, and all participants underwent echocardiographic examination.Results:Left ventricular diastolic functions were determined by both conventional and tissue Doppler methods and were found to be impaired in Group 1 compared to Group 2. Aortic distensibility was significantly reduced in Group 1 compared to Group 2, whereas aortic stiffness index was significantly increased. Left atrial active emptying volume and fraction (LAAEV and LAAEF) were significantly higher in Group 1 than in Group 2. There were significant negative correlations between Vitamin D level and LAAEV, LAAEF, and septal E/E′ ratio and significant positive correlations between Vitamin D level and septal, lateral, anterior, and right ventricular annular E′ velocities.Conclusion:In severe Vitamin D deficiency, echocardiographically assessed diastolic functions appeared particularly impaired, and ventricular myocardial velocities and aortic elastic parameters were also adversely affected. In addition, LA mechanical functions were impaired, probably secondary to disturbed diastolic functions.

Aortic stiffness is increased in patients with hypereosinophilic syndrome being in early necrotic phase.

Persistent eosinophilia and eosinophil-mediated single- or multiple-organ damage are typical features of hypereosinophilic syndrome (HES). Theoretically, eosinophilic infiltration of the ascending aortic wall could not be excluded in HES, therefore the present study aimed to test whether HES is associated with abnormalities in aortic elastic properties. The present study comprised 10 HES patients (mean age: 57.6±10.1 years, 5 males) without known cardiovascular disease, their results were compared to 19 age-, gender- and risk factor-matched controls (59.2±4.2 years, 15 males). Complete two-dimensional Doppler echocardiography with measurement of echocardiographic aortic elastic properties was performed in all HES cases and controls. Although neither systolic (30.6±3.4 vs. 30.1±3.6 mm, P=ns), nor diastolic (28.7±3.6 vs. 27.8±3.2 mm, P=ns) aortic diameter differed significantly between HES patients and matched controls, significantly increased aortic stiffness index (11.19±5.65 vs. 7.04±2.97, P<0.05) could be demonstrated in HES patients. Increased aortic stiffness could be demonstrated in HES patients in their early necrotic phase.

Cardiac amyloidosis is associated with increased aortic stiffness.

Cardiac amyloidosis (CA) is as an infiltrative disorder primarily caused by extracellular tissue deposition of amyloid fibrils in the myocardial interstitium. The current study was designed to test whether alterations in ascending aortic elastic properties could be detected by echocardiography in CA patients, and to compare their results to controls. We included 19 CA patients from which CA proved to be AL amyloidosis in 17 cases and transthyretin (TTR) amyloidosis in 2 cases. Their results were compared to 20 age-, gender-, and risk factor-matched controls. There was significantly greater interventricular septum and left ventricular (LV) posterior wall thickness, lower LV ejection fraction and greater E/A in CA patients than in controls, suggesting systolic, and diastolic dysfunction. CA patients also showed significantly reduced aortic strain and pulsatile change in aortic diameter, and increased aortic stiffness index. These results suggest increased aortic stiffness in CA patients.

Impairment of elastic properties of the aorta in bicuspid aortic valve: relationship between biomolecular and aortic strain patterns.

Bicuspid aortic valve (BAV) is associated with aortic wall alterations. We aimed to detect any correlation between aortic elasticity and genetic and biomolecular patterns of elastin. Forty-nine BAV patients (mean age: 38 ± 17.05) were prospectively enrolled. A blood sample was drawn for analysis of a single nucleotide polymorphism of elastin gene (ELN rs2071307) responsible for misfolding of elastin, and for the amount of elastin soluble fragments (ESF) in the plasma. Aortic dimensions and elastic properties were determined by echocardiography, aortic stiffness (AS) by M-mode analysis, and longitudinal strain (LS) of the ascending aorta (AA) by speckle-tracking echocardiography; values of aortic strain were compared with 45 age-matched subjects (mean age: 33 ± 9.67) with tricuspid aortic valve (TAV). BAV patients had greater aortic dimensions [Valsalva sinus (P = 0.004), sinotubular junction (P = 0.013), AA (P < 0.001)] and stiffness (P = 0.002) but lower LS (P = 0.04) than those with TAV. Results from comparisons of mutated genotype patients (AA, n = 10) with heterozygous (GA, n = 21) and wild-types ones (GG, n = 16) revealed that the presence of mutation was associated with increased ESF (P = 0.010 GG vs. GA; P = 0.035 GA vs. AA), larger AA (P = 0.019 GG vs. GA; P = 0.001 GG vs. AA), and lower LS (P = 0.032 GG vs. AA). Patients with a dilated AA showed greater ESF (P < 0.001), greater AS (P = 0.007), and lower LS of the AA (P = 0.002) than those with a normal AA. The same parameters were not significantly different comparing patients with moderate or severe aortic valve disease and patients with less than moderate valve disease. Our results show a close correlation between genetic and biomolecular patterns of elastin and mechanical properties of the aorta in patients with BAV.

Abstract P521: Relationship Between Carotid Arterial Elastic Properties and Central Aortic Hemodynamics in Patients with Stroke

Objective: Patients with ischemic stroke have more thickened, dilated and stiffer aorta and carotid arteries than patients without. However, there was few data about the relations between the carotid and central aortic elastic properties in those patients. This study aims to investigate the association between carotid artery parameters and central aortic hemodynamics in patients with ischemic stroke. Methods: A total of 101 consecutive patients with ischemic stroke who underwent clinically indicated transesophageal echocardiography (TEE) were performed carotid ultrasonography to assess vascular elastic properties. Using velocity-vector imaging (VVI), instantaneous vessel area (cm 2 ) and deformation as fractional area change (FAC, %) and circumferential strain (%) were obtained in both cross-sectional image of common carotid artery (CA) and descending thoracic aorta (DTA) during TEE. Results: In correlation analysis, elastic properties of DTA including FAC, circumferential strain and vessel area were significantly correlated with the corresponding values of CA, respectively (all p&lt;0.01). Among the vascular parameters, FAC of CA showed independent association with the circumferential strain of DTA adjusting for age, gender, blood pressure, heart rate, intima-media thickness, pulse wave velocity and vessel area (ß=0.14, p=0.002, 95% CI 0.05-0.24) in linear regression analysis. Conclusions: Non-invasively measured elastic properties of CA using VVI showed significant associations with those of DTA and provide valuable information for better understandings of central aortic hemodynamics in patients with ischemic stroke.

1945Remote ischemic conditioning by single cuff inflation improves aortic elastic properties and endothelial glycocalyx thickness in acute myocardial infarction patients

1945Remote ischemic conditioning by single cuff inflation improves aortic elastic properties and endothelial glycocalyx thickness in acute myocardial infarction patients

Aortic elastic properties of familial hypercholesterolemia patients

Aim: Familial hypercholesterolemia (FH) is a genetic disease characterized by premature atherosclerosis due to high cholesterol burden since birth. Aortic stiffness and related elastic properties are associated with subclinical atherosclerosis. We aimed to evaluate the aortic elastic properties in patients with FH.

Assessment of relation between aortic elastic properties and the complexity of coronary artery disease.

Objectives The aim of this study was to evaluate whether there is an independent association between impaired aortic elasticity properties and the complexity of coronary artery disease (CAD) using ...

CRT-400.01 Assessment Of Elasticity Of The Thoracic Aorta Using Diastolic Flow: Validation Of A New MR Method

To assess the value of aortic diastolic flow measured by cardiac magnetic resonance (CMR) imaging as a marker for thoracic aorta elastic properties in Marfan syndrome (MFS) patients. CMR imaging was performed in 146 patients with MFS to measure systolic, diastolic flow, diastolic ratio (diastolic

The reverse remodeling of the aorta in patients after renal transplantation - the value of aortic stiffness index: prospective echocardiographic study

BackgroundAtherosclerosis is regarded as a combination of two major separate diseases: atherosis and sclerosis. Sclerotic component depends on deterioration of elastic properties of the aortic wall and is called aortic stiffness. The most valuable, non-invasive method of aortic stiffness assessment is echocardiography, which allows to calculate the aortic stiffness index (ASI). ASI is an independent predictor of all-cause and cardiovascular mortality in different groups of patients. The main aim of study was the assessment of the aortic reverse remodeling in patients with end-stage renal disease (ESRD) after renal transplantation (RT).MethodsStudy group involved 42 patients aged 43.3 ± 12.6 years, including 19 women aged 49.9 ± 10.9 years and 23 men aged 41.5 ± 12.91 years, who have undergone RT from non-related renal transplant donors, The study protocol has been consisted of 5 stages: 1 week after RT, 3 months after RT, 6 months after RT, 1 year after RT and 3 years after RT. The echocardiographic examination was performed and measurements of Aomax, Aomin were done. On the base of obtained parameters ASI, aortic distensibility (AD) and aortic strain (AS) were calculated according to adequate formulas.ResultsThe improvement of indices characterizing the elastic properties of aorta were noted. These changes attained the statistically significant level only at the end of the observation. ASI just after RT was equal – 4.65 ± 1.58, three months after RT – 4.54 ± 1.49, six months after RT – 4.59 ± 1.61, one year after RT – 4.35 ± 1.21 and three years after RT – 3.35 ± 1.29, while AD reached respectively – 6.55 ± 3.76 cm2/dyn−110−6 just after RT, − 6.38 ± 3.42 cm2/dyn−110−6 three months after RT, − 6.53 ± 3.60 cm2/dyn−110−6 six months after RT, − 6.48 ± 2.79 cm2/dyn−110−6 one year after RT and – 8.03 ± 3.95 cm2/dyn−110−6 three years after RT. Noted AS values were equal – 6.61 ± 4.05%, just after RT, − 6.40 ± 3.58% three months after RT, − 6.56 ± 3.76%, six months after RT, − 6.45 ± 2.80% one year after RT, − 8.01 ± 3.97%. and three years after RT. The exact analysis of parameters concerning aortic function showed that to achieve ASI, AD and AS improvement, long time was needed, because the most significant changes of these indices were observed only between 1 year and 3 years after RT.ConclusionsThere is a relationship between renal transplantation and improvement of the aortic elastic properties. The recovery of the renal function allows to initiate the reparative processes leading to at least partial restitution of the structure and features of the aorta, which is called reverse remodelling. Improvement of aortic wall elastic properties after renal transplantation is a continuous and prolonged process.

Expression of CD4+ CD28null T lymphocytes in children and adolescents with type 1 diabetes mellitus: Relation to microvascular complications, aortic elastic properties, and carotid intima media thickness.

Cardiovascular risk in type 1 diabetes mellitus (T1DM) is associated with endothelial dysfunction, inflammation, and altered immunity. CD4+ CD28null T-cells are a subset of long-lived cytotoxic CD4+ T-lymphocytes with proatherogenic and plaque-destabilizing properties. We hypothesized that the frequency of CD4+ CD28null T-cells may be altered in T1DM and related to vascular complications. To assess the percentage of CD4+ CD28null T-lymphocytes in children and adolescents with T1DM and their relation to vascular structure and glycemic control. Totally 100 patients with T1DM were divided into 2 groups according to the presence of microvascular complications and compared with 50 healthy controls. CD4+ CD28null T-lymphocytes were analyzed using flow cytometry. Aortic elastic properties and carotid intima media thickness (CIMT) were assessed. Aortic stiffness index and CIMT were significantly higher among patients compared with healthy controls while aortic strain and distensibility were decreased. The percentage of CD4+ CD28null T-cells was significantly higher in patients with and without microvascular complications compared with controls. High frequency of CD4+ CD28null T-cells was found among patients with microalbuminuria or peripheral neuropathy. Patients with CD4+ CD28null T-cells ≥10% had higher HbA1c, urinary albumin creatinine ratio, aortic stiffness, and CIMT. CD4+ CD28null T-cells were positively correlated to HbA1c, aortic stiffness index, and CIMT. Changes in aortic elastic properties and increased CIMT among young patients with T1DM may enable the recognition of preclinical cardiac impairment. The correlation between CD4+ CD28null T-cells and assessed parameters of vascular structure highlights the role of altered immune response in the occurrence of diabetic vascular complications.

A Novel Marker of Impaired Aortic Elasticity in Never Treated Hypertensive Patients: Monocyte/High-Density Lipoprotein Cholesterol Ratio.

Monocyte to high density lipoprotein cholesterol ratio (MHR) is generally understood to be a candidate marker of inflammation and oxidative stress. Therefore, we aimed to assess the association between MHR and aortic elastic properties in hypertensive patients. A total of 114 newly-diagnosed untreated patients with hypertension and 71 healthy subjects were enrolled. Aortic stiffness index, aortic strain and aortic distensibility were measured by using echocardiography. Patients with hypertension had a significantly higher MHR compared to the control group (p < 0.001). Also, aortic stiffness index (p < 0.001) was significantly higher and aortic distensibility (p < 0.001) was lower in the hypertensive group. There was a positive correlation of MHR with aortic stiffness index (r = 0.294, p < 0.001) and negative correlation with aortic distensibility (r = -0.281, p < 0.001). In addition, MHR and high sensitivity C-reactive protein have a positive correlation (r = 0.30, p < 0.001). Furthermore, MHR was found to be an independent predictor of aortic distensibility and aortic stiffness index. In patients with newly-diagnosed untreated essential hypertension, higher MHR was significantly associated with impaired aortic elastic properties.

Abstract 11847: Remote Ischemic Conditioning by Single Cuff Inflation Improves Aortic Elastic Properties and Endothelial Glycocalyx Thickness in Acute Myocardial Infarction Patients

Background: Remote ischemic conditioning attenuates ischemia-reperfusion injury in patients with STEMI. However, its effects on vascular function and biochemical mechanisms are not fully defined. Methods: We examined 110 patients with STEMI and 30 healthy controls. Patients were randomised in 2 remote ischemic conditioning protocols after a baseline assessment of vascular function (T0), a) one with two ischemic conditioning stimuli by brachial cuff inflation of both arms at 200mmHg for 5 min, separated by 15min, and each followed by vascular assessment (T1,T2), and a final vascular assessment (T3), 25 min after 2nd cuff deflation (double cuff inlation,n=60 ) or b) a second with omission of the second cuff inflation (single cuff inflation-n=50).In both protocols we measured a) the carotid-femoral pulse wave velocity (PWV);b)perfusion boundary region (PBR- micrometers) of the sublingual arterial microvessels as a marker of endothelial glycocalyx thickness;c) plasma malondialdehyde (MDA),NOx, and IL-6 levels as biomarkers of oxidative stress and inflammation. Results: The single cuff inflation protocol resulted in a more uniform aortic elasticity improvement (PWV T0: 12.09m/s, T1:11.74m/s, T2:11.59m/s, T3:11.81m/s),with the greatest difference measured at the last vascular assessment (T3: PWV= 11.8 single cuff vs 13.8 m/s double cuff inflation,p&lt;0.05).A greater glycocalyx integrity restoration was observed in patients with baseline PBR&gt; 2.1 in both protocols (mean difference in PBR improvement=0.5 at T1, p&lt;0.001).Conversely,in healthy controls, PWV and PBR remained unchanged throughout the study (p&gt;0.05).MDA was significantly reduced at T3 compared to baseline in STEMI(2.1 ± 0.15 at T3 vs 2.59 ±0.15 at T0, p&lt; 0.001) in both protocols while it remained unchanged in healthy controls. Additionally, the single cuff inflation protocol promoted a greater increase in NOx levels compared to the double inflation protocol (T0: 8.25± 1.18 to T3: 11.1 ± 2 μμ vs T0: 10.79± 1.18 to T3: 8.91±2 μμ, p&lt; 0.05). IL-6 levels were unaffected. Conclusion: Remote ischemic conditioning by a single 5-min cuff inflation, confers acute short-term improvement of vascular function, likely through oxidative stress reduction and nitrate- nitrite- NO pathway activation.

Aortic Elastic Properties in Preschool Children Born Preterm.

Preterm birth predisposes children to the development of cardiovascular diseases in adulthood. The aim of this study was to characterize elastic properties of the aorta at preschool age and test the hypothesis that prematurity is associated with decreased aortic distensibility and increased stiffness, both of which are predictors of increased cardiovascular risk. In an observational study of 76 five- to seven-year-old children born at a gestational age <32 weeks and 79 term-born controls, elastic parameters of the ascending and descending abdominal aorta were determined noninvasively by means of M mode echocardiographic tracings and calculated using computerized wall contour analysis. Compared with children born at term, the preterm group showed significantly reduced distensibility and increased stiffness of the descending abdominal aorta. These results remained significant under multivariable adjustment for birth weight z score, maternal smoking in pregnancy, maternal education, family history of cardiovascular disease, breastfeeding, childhood nutrition, and current body mass index z score (multivariable odds ratios and 95% confidence intervals 5.1, 1.7-15.9; P=0.005 and 2.8, 1.0-7.9; P=0.046, respectively). Further adjustment for intravenous lipid therapy attenuated the strength of association. Elastic properties of the ascending aorta did not differ between the 2 study groups. Children born preterm are characterized by decreased elastic properties of the descending abdominal aorta potentially attributable to impaired viscoelastic properties of and lipid damage to the aorta. Clinical follow-up of preterm infants with a focus on aortic elastic properties may be useful for tailoring early prevention programs and counteracting cardiovascular risk in adulthood.

A novel variant in MYLK causes thoracic aortic dissections: genotypic and phenotypic description.

BackgroundMutations in MYLK cause non-syndromic familial thoracic aortic aneurysms and dissections (FTAAD). Very little is known about the phenotype of affected families. We sought to characterize the aortic disease and the presence of other vascular abnormalities in FTAAD caused by a deletion in MYLK and to compare thoracic aortic diameter and stiffness in mutation carriers and non-carriers.MethodsWe studied FTAAD in a 5-generation family that included 19 living members. Exome sequencing was performed to identify the underlying gene defect. Aortic elastic properties measured by TTE, MRI and pulse wave velocity were then compared between mutation carriers and non-carriers.ResultsExome sequencing led to the identification of a 2-bp deletion in MYLK (c3272_3273del, p.Ser1091*) that led to a premature stop codon and nonsense-mediated decay. Eleven people were mutation carriers and eight people were non-carriers. Five aortic ruptures or dissections occurred in this family, with two survivors. There were no differences in aortic diameter or stiffness between carriers and non-carriers of the mutation.ConclusionsIndividuals carrying this deletion in MYLK have a high risk of presenting with an acute aortic dissection or rupture. Aortic events occur over a wide range of ages and are not always preceded by obvious aortic dilatation. Aortic elastic properties do not differ between carriers and non-carriers of this mutation, rendering it uncertain whether and when carriers should undergo elective prophylactic surgery.

Impact of Decreased Serum Insulin-Like Growth Factor-1 Levels on Central Aortic Compliance in Small-for-Gestational-Age Infants

Background: Intrauterine growth restriction is associated with arterial hypertension in adulthood; however, the underlying mechanism is unclear. Objectives: We hypothesized that serum insulin-like growth factor-1 (IGF-1) levels affect central aortic elastic properties and structure in small-for-gestational-age (SGA) infants. Methods: Eighteen SGA infants and 22 appropriate-for-gestational-age (AGA) infants were enrolled in this study. The serum IGF-1 level within 1 h of birth and abdominal aortic echo parameters at 1 week of age were retrospectively compared. Results: In the SGA infants, IGF-1 levels (27.6 ± 17.7 vs. 42.6 ± 15 ng/ml, p = 0.006), aortic strain (10.2 ± 3.1 vs. 12.8 ± 3.1%, p = 0.01), and aortic distensibility (0.73 ± 0.19 vs. 0.92 ± 0.34 cm²/dyn × 10^-4, p = 0.05) were significantly lower compared with AGA infants. By contrast, blood pressure, aortic intima-media thickness (aIMT) in relation to body weight (383 ± 163 vs. 256 ± 43 μm/kg, p < 0.001), aortic stiffness index in relation to body weight (2.0 ± 1.7 vs. 1.1 ± 0.4, p = 0.005), and arterial pressure-strain elastic modulus (293 ± 72 vs. 242 ± 78 mm Hg, p = 0.04) were higher compared with AGA infants. In the SGA infants, IGF-1 levels were significantly correlated with aortic strain (r = 0.49, p = 0.04), aIMT in relation to body weight (r = -0.61, p = 0.007), and aortic stiffness index in relation to body weight (r = -0.63, p = 0.005). Conclusions: Decreased serum IGF-1 levels in SGA infants may affect the vascular compliance and structure of the central aorta.

Aortic elasticity indices by magnetic resonance predict progression of ascending aorta dilation.

Aortic distensibility and pulse-wave velocity (PWV) are under investigation as parameters by which to evaluate the indication for ascending aorta (AA) replacement. The maximum rate of systolic distension (MRSD) was proposed as a new index of aortic elasticity. The aim of this study was to assess the role of aortic elasticity parameters to predict AA growth rates in patients with AA dilation (AAD). Magnetic resonance imaging (MRI) was performed annually in 65 patients with AA dilation (median follow-up 17months; 25-75th percentile; range 12-30months). A significant increase in AA diameter was defined as a ≥2-mm increase. An increase in AA diameter was found in 42 (68%) patients (AAD+ group) and absent in 20. Median increase was 0.16 (25-75th percentile; range 0.32-0.7) mm/month. The AAD+ group had a lower MRSD (4.6 ± 2.2 vs 7.4 ± 2.0, p < 0.001) but the same PWV and distensibility. MRSD showed 93.7% specificity and 75.6% sensitivity for prediction of increase. Patients with MRSD ≤ 6 had lower progression-free survival times (p < 0.002). After a follow-up of 4.1years, patients who underwent surgical therapy had lower MRSD and distensibility than others. MRSD is an index of aorta elastic properties and is a valuable predictor for progression in AAD. • MRI-derived parameters of aortic wall elasticity predict progression of ascending aorta dilation. • Maximal rate of systolic distension (MRSD) was the best predictor of progression. • Patients with MRSD ≤ 6 had lower progression-free survival (PFS) times. • Patients who underwent surgical therapy had lower MRSD and distensibility. • MRI-derived parameters identify patients with fast progression of Ascending Aorta Dilation.

Assessment of relation between aortic elastic properties and the complexity of coronary artery disease

Objectives The aim of this study was to evaluate whether there is an independent association between impaired aortic elasticity properties and the complexity of coronary artery disease (CAD) using the SYNTAX score (SS).Methods Three hundred sixty-seven patients (male 64.9%) aged 31 to 89 years (average age 62.07 years) with CAD who underwent coronary angiography were enrolled in this study. Patients with a SS ≤ 17 (n = 211; male 66.8%) were classified as the low SS group (Low-SSG), from 18 to 28 (n = 108; male 61.1%) were classified as the intermediate SS group (In-SSG), and ≥ 29 (n = 44; male 64.6%) classified as the high SS group (High-SSG). In all groups, aortic elastic properties were obtained from hospital records. These properties, including aortic diameter change (AoDC), aortic stiffness (AoS), aortic stiffness index- β(AoSI-β), aortic distensibility (AoD), aortic Petersen’s elastic modulus (AoEp), aortic compliance (AoCI) and the compliance to distensibility ratio (AoCDR), were compared.Results AoS was significantly lower in High-SSG than in Low-SS and In-SSG, (P =0.004). However, the AoEp in High-SSG was significantly higher than in Low-SSG and In-SSG, (P =0.012). A negative correlation was detected between the SS and each of AoDC, AoS, AoD, AoCI and AoCDR. A positive correlation was detected between the SS and AoSI- βand AoEp in the patients with CAD.Conclusion This study demonstrated that aortic elastic properties are more impaired in patients with severe and complex CAD. There is an independent relationship between reduced aortic elasticity and the severity and complexity of CAD.

OP-062 Aortic Elastic Properties Do Not Differ in Patients With Mitral Valve Prolapse

OP-062 Aortic Elastic Properties Do Not Differ in Patients With Mitral Valve Prolapse