The International Conference on Mathematical Modeling in Physical Sciences (IC-MSQUARE) is an interdisciplinary scientific event which aims to promote the knowledge and the development of high-quality research in mathematical fields that have to do with the applications of other scientific fields and the modern technological trends that appear in them, these fields being those of Physics, Chemistry, Biology, Medicine, Economics, Sociology, Environmental sciences etc.The 12th IC-MSQUARE took place in Belgrade, Serbia between August 28 and 31, 2023. In addition, (because in previous years the conference, due to the pandemic, took place only with online presentations), the possibility of participation via the internet was also adopted this time. Thus, apart from the talks and workshops held on site, we also had a large collection of pre-recorded presentations that were available to the participants through the conference website.The Conference was attended by more than 350 participants and hosted about 320 oral and virtual presentations while counted more than 1000 pre-registered authors. The 12th IC-MSQUARE consisted of different and diverging workshops and thus covered various research fields where Mathematical Modeling is used, such as Theoretical and Mathematical Physics, Neutrino Physics, Non-Integrable Systems, Dynamical Systems, Computational Nanoscience, Biological Physics, Computational Biomechanics, Complex Networks, Stochastic Modeling, Fractional Statistics, DNA Dynamics, Macroeconomics, Social Modeling etc.The scientific program was rather heavy, however, according to all attendees, the program was excellent with high level of talks and the scientific environment was fruitful, thus all attendees had a creative time.All papers submitted to the Conference have been reviewed using a single-blind peer-review process. The review process adopted a scoring system (0-5 points) who rated the Relevance, Scientific quality, Contribution, Title and paper presentation, Tables and figures, Language and the References of each paper. The threshold for an article to be accepted was a score above 4 for the majority of the evaluated papers. Additionally, each paper was tested for similarity with already published content using the Turnitin software. All sources of similarities were checked and only original content was accepted. In this way, out of 308 papers that were evaluated for this volume, only 167 were accepted for publication.We would like to thank the Reviewers, the Members of the International Scientific Committees as well as the Members of the Organizing Committee.The Conference ChairmanDimitrios VlachosUniversity of PeloponneseList of International Scientific Committee, Organizing Committee are available in this pdf.