Since to the nursing problems existing in percutaneous vertebroplasty (PVP) for elderly patients, the effect of individualized music nursing during the PVP operation was summarized and analyzed. 80 cases of PVP patients over 60 years old were randomly divided into the experimental group and the control group. In the experimental group, PVP patients were treated with individualized music nursing, but the control group was treated with the conventional surgical environment. Patients’ music background were compared between the two groups. The preoperative and intraoperative anxiety scores of patients based on the State Anxiety Questionnaire (S-AI) were analyzed in two groups. And coordination between doctor and patients during the surgery were also evaluated. Results showed that there was no significant difference in the music background between the two groups (P> 0.05). In addition, there was no significant difference in preoperative anxiety scores between the two groups (P>0.05), but there were significant differences in the intraoperative anxiety scores between the two groups (P<0.05). Furthermore, patients treated with individualized music nursing had better surgical cooperation than the control group (P<0.05), and the satisfaction rate of doctors (82.5%) was higher than the control group (47.5%). In conclusion, the application of individualized music nursing in PVP surgery for elderly patients could reduce the patients' anxiety and facilitate collaboration between doctors and patients during operation.