There is no part of the world can be cleared of the infection with dermatophytosis. Millions of persons and animals around the world are infected with specialized filamentous fungi called superficial infections of which dermatophyte are the most common agents. Dermatophyte infection incorporates a broad range of diseases involving particularly the nails, hair, and the skin. These infections were considered the most common causative agents of a patient visiting the dermatology. Dermatophytosis is mainly due to different species of dermatophytes that infect the cutaneous layer of the skin. There are many problems in the treatment of dermatophytosis that deserve to highlight because few studies have discussed this issue, especially dermatophyte management challenges became the state of anxiety in physicians and causing alarming distress to the patients recently. So the current review may serve as an impetus for researchers working in the field of medical mycology and antifungal drug design, as well as rationally reports and critically analyses the available knowledge by focusing and mentioning future steps strategies trying to find appropriate solutions regarding challenges in dermatophytosis management.