Introduction: This study was conducted to compare Covid-19 anxiety in mothers with cancer children and mothers with children who have other diseases during the Covid-19 pandemic.
 Methods: This was a descriptive-analytical and cross-sectional study conducted on 250 mothers with cancer children and mothers with children who have other diseases. They visited the clinic and oncology department of Shahid Sadoughi Hospital in Yazd in 1400.
 Convenience sampling method was used. Data collection tools were demographic information and Covid-19 anxiety questionnaires. Data were analyzed with a confidence level of 95%.
 Results: The mean anxiety score of mothers of children with cancer was 36.36±11.16. The mean anxiety score of mothers of children with other diseases was lower ( 34.65±10.82), based on the t-test statistical test, but no significant difference was statistically observed between them.
 Conclusion: Findings showed that, in general, the average anxiety of mothers in both groups was high (more than 30 out of 54), but there was no significant difference between them regarding the anxiety score.
 More studies should be done in different situations and times to more precisely determine the factors affecting the intensity of anxiety of mothers with cancer children .