Anxiety In Group Research Articles

Analyzing the correlation between gastroesophageal reflux disease and anxiety and depression based on ordered logistic regression

Numerous studies have indicated a connection between psychiatric symptoms, specifically anxiety and depression, and gastroesophageal reflux. However, the precise nature of the link between the severity of gastroesophageal reflux disease and the severity of anxiety and depression remains uncertain. Here, we gathered 24-h pH monitoring data and baseline patient information from a cohort of 518 individuals. Additionally, we evaluated their psychological well-being using the Hospital Anxiety and Depression Scale. The relationship between baseline characteristics and varying degrees of anxiety, depression, and gastroesophageal reflux disease (GERD) was assessed using R software version 4.1.3 and logistic regression models. The findings indicate a statistically significant variation in anxiety levels based on gender, as well as a significant disparity in depression groups when considering age and literacy levels. Kruskal–Wallis test analysis revealed a significant positive correlation between the severity of anxiety and depression and the 24-h pH monitoring results in our patient cohort. As the anxiety and depression levels increased, the rank mean for each examination result also increased. Logistic regression modeling analysis showed that a higher anxiety level was associated with a higher level of GERD. In the presence of mild anxiety, there is a statistically significant association with a higher incidence of GERD with an odds ratio (OR) of 2.64 (95% CI 1.50, 4.64). Similarly, the moderately severe anxiety group also exhibits a causal relationship with an increased GERD incidence, with an OR of 6.84 (95% CI 3.92, 12.17). Additionally, moderate to severe depression is associated with a higher incidence of GERD, with an OR of 2.32 (95% CI 1.23, 4.37). The prevalence of GERD was greater among males compared to females (OR 2.29, 95% CI 1.51–3.49). Additionally, an elevated body mass index (BMI) demonstrated a positive correlation with the susceptibility to GERD (OR 1.07, 95% CI 1.01–1.14). Increasing age may promote the occurrence of GERD in patients. These findings may help to provide a better basis for psychological or pharmacological interventions for GERD patients with psychosomatic symptoms in the future, and provide a reference basis for clinical treatment of the disease.

A mixed-method study evaluating an innovative care model for rural patients undergoing outpatient breast surgery.

The Delta Oasis program was launched in New Brunswick in 2006 to offer patients from rural areas who were undergoing breast cancer surgery and their families 1 night of free accommodations and a postoperative consultation with an extramural nurse. We sought to investigate patient experiences with this program. This mixed-method retrospective study took place from 2020 to 2022 and compared the preoperative anxiety and quality of recovery of program participants and control patients who were discharged home over 100 km from hospital. We conducted 2 × 2 analysis of variance to evaluate the effects of intervention group and surgery type. We conducted semistructured interviews with intervention participants, which we then thematically analyzed. Two patient partners were engaged during data synthesis to support the interpretation of results. We included 34 patients who participated in the program and 18 control patients. No statistically significant differences were found between treatment groups in preoperative anxiety and quality of recovery, regardless of surgery type. Thematic analysis of interviews with 17 intervention participants revealed that they were highly satisfied with the program and that the experience helped reduce stress and discomfort related to their surgery. The Delta Oasis program is a cost-effective alternative to inpatient care after breast cancer surgery and is highly regarded by rural patients; expansion to other regions with the inclusion of additional low-risk surgeries could help address hospital capacity issues. This study contributes to our understanding of the patient experience with the Delta Oasis program and informs the development of similar programs elsewhere.

Mathematics anxiety and number processing: The link between executive functions, cardinality, and ordinality.

One important factor that hampers children's learning of mathematics is math anxiety (MA). Still, the mechanisms by which MA affects performance remain debated. The current study investigated the relationship between MA, basic number processing abilities (i.e., cardinality and ordinality processing), and executive functions in school children enrolled in grades 4-7 (N = 127). Children were divided into a high math anxiety group (N = 29) and a low math anxiety group (N = 31) based on the lowest quartile and the highest quartile. Using a series of analyses of variances, we find that highly math-anxious students do not perform worse on cardinality processing tasks (i.e., digit comparison and non-symbolic number sense), but that they perform worse on numerical and non-numerical ordinality processing tasks. We demonstrate that children with high MA show poorer performance on a specific aspect of executive functions-shifting ability. Our models indicate that shifting ability is tied to performance on both the numerical and non-numerical ordinality processing tasks. A central factor seems to be the involvement of executive processes during ordinality judgements, and executive functions may constitute the driving force behind these delays in numerical competence in math-anxious children.

Antecedents of maternal pregnancy-related anxiety trajectories: The FinnBrain birth cohort study.

Little is known about the normative courses of pregnancy-related anxiety throughout pregnancy and their antecedents. We examined in a large scale pregnancy cohort which potentially distinct trajectories of pregnancy-related anxiety across pregnancy can be identified, and which factors predict these trajectories. A general sample of pregnant women (n = 2928) from the FinnBrain Birth Cohort participated in this study. Several questionnaires were filled in at 14, 24, and 34 weeks of gestation, including the pregnancy-related anxiety questionnaire-revised as main outcome. Latent Growth Mixture Modeling was applied to identify the trajectories of pregnancy-related anxiety across pregnancy, and t-tests and chi-quare tests were conducted to find antecedents of these trajectories. Two distinct trajectories were identified: (1) a low symptoms group, N = 2594 (88.6%), with lower and slightly increasing levels of pregnancy-related anxiety (2) a moderately-high symptoms group, N = 334 (11.4%) reported higher and slightly decreasing levels of anxiety. Correlates of the moderately-high anxious group included a lower monthly income, drinking alcohol or smoking in early pregnancy, more daily hassles and less joy, more early life adversities, younger age, primiparity, single parenthood, using depression medication, and having higher scores on depression and general anxiety. Although the majority of pregnant women fall within a low risk trajectory of pregnancy-related anxiety, another group with consistently higher levels of pregnancy anxiety throughout pregnancy may need more clinical attention, as their high pregnancy-related anxiety scores may indicate a risk profile that includes a variety of general and more pregnancy-specific risk factors, which together can negatively affect fetal and infant development and behavior.

The association between the deviation from balanced time perspective on adolescent pandemic mobile phone addiction: the moderating role of self-control and the mediating role of psychological distress.

Few studies have examined the impact that the deviation from balanced time perspective (DBTP) had on mobile phone addiction during the COVID-19 normalization prevention and control phase. Therefore, this study sought to determine the associations between DBTP, depression and anxiety, self-control, and adolescent mobile phone addiction. The moderated mediating model was tested using the SPSS PROCESS model. The sample was 1,164 adolescents from different regional areas of Sichuan, China. From February to March 2020, participants completed the Zimbardo time perspective inventory (ZTPI), the brief symptom inventory for physical and mental health (BSI-18), the self-control scale (SCS), and the Chinese version of the mobile phone addiction index (MPAI). The DBTP was significantly and positively correlated with mobile phone addiction, depressive and anxiety symptoms mediated the relationship between DBTP and mobile phone addiction, self-control moderated the indirect effect of DBTP on mobile phone addiction, and as the level of self-control increased, the effect of DBTP on anxiety and depression and the effect of depression and anxiety on mobile phone addiction weakened. During the COVID-19 pandemic, DBTP and lower self-control were risk factors for higher mobile phone addiction in adolescents. Therefore, guiding adolescents to balance their time perspective and enhance their self-control could strengthen their psychological well-being and reduce addictive mobile phone behaviors. This research was supported by "Youth Fund of the Ministry of Education" (18YJCZH233): "Research on the plastic mechanism of decision-making impulsiveness of anxious groups in the context of risk society."

Effects of Two Group Prenatal Care Interventions on Mental Health: An RCT

Perinatal depression and anxiety cost the U.S. health system $102 million annually and result in adverse health outcomes. Research supports that cognitive behavioral therapy improves these conditions, but barriers to obtaining cognitive behavioral therapy have prevented its success in pregnant individuals. In this study, the impact of a cognitive behavioral therapy-based intervention on anxiety, depression, stress, healthy lifestyle beliefs, and behaviors in pregnant people was examined. This study used a 2-arm RCT design, embedded in group prenatal care, with one arm receiving a cognitive behavioral therapy-based Creating Opportunities for Personal Empowerment program and the other receiving health promotion content. Black and Hispanic participants (n=299) receiving prenatal care from 2018 to 2022 in New York and Ohio who screened high on 1 of 3 mental health measures were eligible to participate. Participants were randomized into the manualized Creating Opportunities for Personal Empowerment cognitive behavioral therapy-based program, with cognitive behavioral skill-building activities delivered by advanced practice nurses in the obstetrical setting. Outcomes included anxiety, depression, and stress symptoms using valid and reliable tools (Generalized Anxiety Disorder scale, Edinburgh Postnatal Depression Scale, and Perceived Stress Scale). The Healthy Lifestyle Beliefs and Behaviors Scales examined beliefs about maintaining a healthy lifestyle and reported healthy behaviors. There were no statistically significant differences between groups in anxiety, depression, stress, healthy beliefs, and behaviors. There were significant improvements in all measures over time. There were statistically significant decreases in anxiety, depression, and stress from baseline to intervention end, whereas healthy beliefs and behaviors significantly increased. Both cognitive behavioral therapy and health promotion content embedded in group prenatal care with advanced practice nurse delivery improved mental health and healthy lifestyle beliefs and behaviors at a time when perinatal mood generally worsens. This study is registered with clinicaltrials.gov NCT03416010.

Trajectories of anxiety and depression among Chinese men who have sex with men on pre-exposure prophylaxis: a group-based trajectory model approach

BackgroundAnxiety and depression can influence adherence to Pre-exposure Prophylaxis (PrEP). However, there is limited research on the temporal dynamics of anxiety and depression among men who have sex with men (MSM) using PrEP.MethodsFrom December 2018 to November 2020, we administered the Hospital Anxiety and Depression Scale (HADS) to participants in the China Real-World Oral Intake of PrEP (CROPrEP) to measure their anxiety and depression levels. The group-based trajectory model (GBTM) depicted the dynamic changes of anxiety and depression scores over time.ResultsA total of 1023 MSM were included, with 4523 follow-up assessments. The GBTM categorized the trajectories into three distinct patterns: consistently low (54.8% for anxiety, 60.7% for depression), consistently moderate (39.3% for anxiety, 31.4% for depression), and high but bell-shaped (5.9% for anxiety, 7.9% for depression). Higher anxiety levels were associated with being aged 18–30 years old, earning less than US$619 per month, female-identifying, adopting the bottom sexual role with men, and having two or more anal sex partners in the past three months; similarly, higher depression levels correlated with a monthly income under US$619, female-identifying, sexual behavior as bottom and a positive syphilis at baseline. PrEP adherence was notably lower in the high but bell-shaped anxiety and depression group compared to the other groups, particularly at the 12th-month follow-up.ConclusionsClose monitoring of anxiety and depression levels in MSM on PrEP is crucial. Provision of targeted mental health support is essential to enhance PrEP effectiveness.

The effect of working memory load on selective attention to emotional faces for social anxiety individuals.

Research has confirmed that individuals with social anxiety (SA) show an attentional bias towards threat-related stimuli. However, the extent to which this attentional bias depends on top-down cognitive control processes remains controversial. The present study investigated the effect of working memory (WM) load on selective attention to emotional faces in both high social anxiety (HSA) and low social anxiety (LSA) groups by manipulating WM load through the inclusion of forward counting in multiples of two (low load) or backward counting in multiples of seven (high load) within a modified flanker task. In the flanker task, emotional faces (angry, happy, or neutral faces) were used as targets and distractors. A total of 70 participants (34 HSA participants; 36 LSA participants) completed the flanker task in the laboratory. The results showed that the HSA individuals performed worse when responding to angry targets. Relative to LSA individuals, HSA individuals showed interference from angry distractors in the flanker task, resulting in significantly lower accuracy in identifying angry targets compared to happy targets. These results were unaffected by the manipulation of WM load. The findings imply HSA individuals have impaired attentional control, and that their threat-related attentional bias relies more on the bottom-up automatic attentional process.

Preoperatif Durumluk-Sürekli Anksiyete Düzeyi ve Uygulanan Anestezi Tekniğinin Postoperatif Bulantı ve Kusmaya Etkisi

Objective: It was aimed to determine the effect of preoperative anxiety levels and anesthesia of the patients on postoperative nausea and vomiting (PONV). Methods: This study was a cross sectional research. It was conducted with 323 patients at a state hospital between April-June 2022. Data were collected with Sociodemographic and Clinical Characteristics Form, State-Trait Anxiety Inventory (STAI), and Rhodes Index of Nausea, Vomiting, and Retching. Descriptive statistics were applied to analyze the data. Results: The mean age of the patients were 50.5 ± 17.3 years, and 18.9% of them were treated in the general surgery ward. There was a significant difference in the development of PONV in the Trait Anxiety Inventory (STAI-T) severe anxiety group compared to the mild anxiety group (p=0.031) and in the State Anxiety Inventory (STAI-S) moderate anxiety group compared to the mild anxiety group (p=0.012). When anesthetic type was included in the model, there was a significant difference in the development of PONV between the STAI-S moderate and mild anxiety groups (p=0.006). State Anxiety Inventory scores were found to be effective in the group that received general and spinal anesthesia (p=0.013). Postoperative nausea and vomiting development was 41.2% in the moderate anxiety group and 21.7% in the mild anxiety group in the general and spinal anesthesia group. Conclusion: It was determined that undergoing general or spinal anesthesia increases the risk of developing PONV as the STAI-S score increases. Keywords: Surgery, anxiety, nausea, vomiting

Circulating sex hormones in women with severe anxiety during pregnancy

Introduction. Anxiety, mood- and stress-related behaviors are regulated by sex hormones in pregnant and non-pregnant women. Very scarce information exists about the role of sex steroids in pregnant women displaying high levels of anxiety. Objective. To determine sex hormones serum levels in pregnant women exhibiting high levels of anxiety symptoms. Method. The Hamilton Anxiety Rating Scale (HARS/ HAM-A) was used to assess the intensity of anxiety symptoms in third-trimester pregnant women. Two groups were included in the study, pregnant women exhibiting severe anxiety (ANX; HARS scores ≥ 25; n = 101) and healthy control subjects (CTRL; n = 40) displaying lower scores for anxiety (HARS scores ≤ 7). Estradiol (E2), progesterone (P4), and testosterone (T) serum levels were measured using a standard chemiluminescent immunoassay. Bivariate and partial correlations were performed to detect significant associations between groups, clinical measures, biochemical data, and HARS scores. Results. The anxiety group (ANX) showed an increase in E2 and T serum levels (p () .001) compared to CTRL. Conversely, significantly lower P4 levels were found in the symptomatic group (p () .001) as compared to the CTRL hormone values. The P4:E2 index was significantly reduced in pregnant women with high levels of anxiety (p () .001). Negative correlations between anxiety (HARS) scores, P4 serum levels (p = .02), and P4:E2 ratio (p = .04) were found in the symptomatic group. Conversely, T serum levels displayed a positive association (p = .001) with high levels of anxiety symptoms in the same group, after adjusting our data by clinical confounders. Discussion and conclusion. Serum levels of sex-steroid hormones are altered in pregnant women exhibiting severe anxiety.

Effects of Interventions Based on Patient Expectations on Coronary Surgery Outcomes: A Randomized Clinical Trial.

Coronary surgery can have various outcomes, such as fear of death, cardiac anxiety, and pain disability. This study aimed to evaluate the effects of interventions based on patient expectations on different outcomes of coronary surgery, including expectations, cardiac anxiety, and pain-induced disability. This randomized clinical trial evaluated 60 coronary surgery candidates. Patients meeting the inclusion criteria were randomly assigned to control and intervention groups. The patients were contacted 1 to 2 weeks before coronary surgery to complete the Cardiac Surgery Patient Expectations Questionnaire (C-SPEQ). Based on the analysis of expectations, the intervention group underwent interventions to optimize expectations, whereas the control group received only routine care. The Cardiac Anxiety Questionnaire (CAQ) and the Pain Disability Index (PDI) were completed on the day of hospitalization. Three months later, the participants recompleted all 3 questionnaires. The data were analyzed with descriptive and analytical statistics in SPSS 16.0. There were no significant differences between the control and intervention groups in baseline variables, pain-induced disability (P=0.353), and cardiac anxiety (P=0.479). After the intervention, no significant differences were observed between the groups concerning expectations (P=0.554) and pain-induced disability (P=0.557) when the confounding variables were adjusted. Nevertheless, cardiac anxiety decreased significantly (P=0.027). Our interventions improved expectations and mitigated anxiety among coronary surgery patients. Actualization and optimization of patient expectations should be considered in the care of coronary surgery candidates.

Electrophysiological signatures of anxiety in Parkinson’s disease

Anxiety is a common non-motor symptom in Parkinson’s disease (PD) occurring in up to 31% of the patients and affecting their quality of life. Despite the high prevalence, anxiety symptoms in PD are often underdiagnosed and, therefore, undertreated. To date, functional and structural neuroimaging studies have contributed to our understanding of the motor and cognitive symptomatology of PD. Yet, the underlying pathophysiology of anxiety symptoms in PD remains largely unknown and studies on their neural correlates are missing. Here, we used resting-state electroencephalography (RS-EEG) of 68 non-demented PD patients with or without clinically-defined anxiety and 25 healthy controls (HC) to assess spectral and functional connectivity fingerprints characterizing the PD-related anxiety. When comparing the brain activity of the PD anxious group (PD-A, N = 18) to both PD non-anxious (PD-NA, N = 50) and HC groups (N = 25) at baseline, our results showed increased fronto-parietal delta power and decreased frontal beta power depicting the PD-A group. Results also revealed hyper-connectivity networks predominating in delta, theta and gamma bands against prominent hypo-connectivity networks in alpha and beta bands as network signatures of anxiety in PD where the frontal, temporal, limbic and insular lobes exhibited the majority of significant connections. Moreover, the revealed EEG-based electrophysiological signatures were strongly associated with the clinical scores of anxiety and followed their progression trend over the course of the disease. We believe that the identification of the electrophysiological correlates of anxiety in PD using EEG is conducive toward more accurate prognosis and can ultimately support personalized psychiatric follow-up and the development of new therapeutic strategies.

P216 Urine Metabolomic Characteristics of Anxiety and Depression Disorders in Patients with Inflammatory Bowel Disease

Abstract Background Up to 25%-35% of patients with inflammatory bowel disease (IBD) suffer from anxiety or depression. We aimed to depict the urine metabolic profile of IBD patients with anxiety and depression disorders and investigate the urinary metabolites that could characterize the mental disorders in IBD patients. Methods Urine samples were collected from IBD patients, and the Liquid Chromatography-Mass Spectrometry (LC-MS) was used to detect the metabolites. The Hospital Anxiety and Depression Scale (HADS) was used to assess the anxiety and depression symptoms. Least absolute shrinkage and selection operator (LASSO) regression model with 10-fold cross-validation was used to establish a metabolite-based prediction model for mental disorders in patients with IBD. Results Among the involved IBD patients (n=23, median age 41, women 61%), 35% had anxiety and 35% had depression. The urine metabolic profiles of IBD patients with anxiety or depression disorders were largely separated from those without mental symptoms (Figure 1 a-b). There were 36 metabolites up-regulated and 25 metabolites down-regulated in the anxiety group, while 10 metabolites up-regulated and 35 metabolites down-regulated in the depression group (Figure 1 c-d). The LASSO model identified the metabolites predicting IBD patients with mental disorders (Figure 2 a-b). Six metabolites (L-Carnitine, Riboflavin-5-phosphate, 2-Ethyl-2-phenylmalonamide, 3-Indoxyl sulphate, Sodium cholate, Tritylalcohol) were selected to construct the prediction model for anxiety, and another six metabolites (D-(-)-Glutamine, dAMP, DL-Stachydrine, dCMP, 5'-Deoxy-5'-(Methylthio)Adenosine, Sakuranin) were selected to construct the prediction model for depression in IBD patients. Both models showed excellent performances with an AUC of 0.992 (95%CI:0.97-1.00) and 0.933 (95%CI: 0.83-1.00) for predicting anxiety and depression, respectively, among patients with IBD (Figure 2 c-d). Conclusion We found significantly different urine metabolic profiles between IBD patients with and without anxiety and depression disorders. The specific urinary metabolites panel may become effective biomarkers for the prediction of anxiety and depression disorders in IBD patients.

Age differences and profiles in pro-environmental behavior and eco-emotions

Previous research suggests that age-related differences in pro-environmental behavior (PEB) and the emotional reactions to climate change could originate from generational as well as aging effects and can be influenced by the opportunities and constraints of life circumstances and resources. The current research aimed to better understand age differences through examining the eco-emotions and PEBs of different age groups, and identifying latent groups differing on these variables. In Sample 1, adults from the general population ( n = 4,685) filled out questionnaires assessing eco-anxiety, eco-guilt, and ecological grief and answered 12 questions about their PEBs. In Sample 2 (A), the same PEB questions were answered by high school students ( n = 112) and in Sample 2 (P) by one of their parents ( n = 112). There were no age differences in the overall PEB score, but we found significant, nonlinear differences between age groups in almost all individual PEBs. Eco-friendly clothing and using greener transport were more common in the younger age groups, while older age groups had higher scores in conservation, recycling, reduced meat consumption, and boycotting. Students were less likely to recycle, use reusable bags, eat less meat and save water than their parents, but more likely to use greener transportation. Five latent groups emerged on the eco-emotions and PEB measures. Young adults had a higher probability of belonging to the medium/higher anxiety groups than the older generations, except for those in their 70s. Groups with higher emotional concern showed higher behavioral involvement. Since most participants showed a moderate level of worry, this emotional reaction appears a normative response to the climate crisis and also a possible starting point for promoting PEBs. The findings also suggest that each generation has its preferences in terms of PEBs, and it is worthwhile to address each of the different PEBs separately.

Qualitative Study of Anxiety Facing Block Examinations Among Medical Students at Faculty of Medicine, Universitas Ahmad Dahlan

Background: Medical students face examinations more frequently compared to students from other faculties. Examinations are one of the causes of anxiety commonly experienced by medical students, leading to both physical and psychological responses. Effective coping mechanisms in response to stressors are necessary for medical students as a defense mechanism. Objective: This research aims to explore the causes of exam anxiety, the contributing factors to anxiety and the coping mechanism used by medical students. Methods: The research adopts a qualitative descriptive design, the sample consist of active medical students from Faculty of Medicine, Ahmad Dahlan University who have faced block examinations. Sample selection was done using a test- anxiety inventory, with participants chosen from each academic year and divided into focus group discussion (FGD) sessions. The FGD results were subsequently analyzed using content analysis in the form of research problem categories. Results: The discovered data consists of the main research issues, which are student’s anxiety when facing block exams, the factors causing anxiety, and student’s coping mechanisms. Conclusion: The high anxiety group portrays block exams as a subjective matter and tends to lead to anxiety, students in low anxiety group predominantly utilize problem-focused coping mechanism.

Investigating the Effect of a Group Psychoeducation Program on Test Anxiety: Implementation of the Balance Model within the Context of Positive Psychotherapy

The aim of this study is to investigate the effect of a Test Anxiety Group Psychoeducation Program based on the Balance Model within the context of Positive Psychotherapy on the test anxiety scores of high school students experiencing test anxiety. The experimental group consisted of 14 students, 8 females and 6 males, attending the 11th grade in a state high school in Ankara/Türkiye, who were identified by the school guidance service as experiencing test anxiety. The students in the psychoeducation group were assigned using the purposive sampling method, a non-random sampling technique and a subset of purposeful sampling. The Test Anxiety Group Psychoeducation Program was based on the Balance Model within the context of Positive Psychotherapy and consisted of 6 sessions lasting 90 minutes each, utilizing methods mainly from positive psychotherapy, drama techniques, and stories. A Test Anxiety Inventory comprising 20 items was administered to the participants. The subscale scores of Emotionality and Worry, as well as Overall Anxiety Score were utilized. A single-group, pre-test post-test experimental design was used in the research. The outcomes showed that after participating in the Test Anxiety Group Psychoeducation Program, the experimental group’s test anxiety scores significantly decreased.

The cognitive neural mechanism of trait anxiety influences mind wandering: An ERP study

Converging evidence from behavioral and neuroscience studies demonstrated that our attention to the external world is influenced by emotion, especially anxiety. However, little is known about how trait anxiety influences neural and behavioral responses during mind wandering. The present study aimed to examine the neural and cognitive time courses of how trait anxiety affects mind wandering. Event-related potentials (ERPs) were recorded from 20 individuals with high trait anxiety and 20 with low trait anxiety when they performed the Sustained Attention to Response Task (SART) in which they were asked to respond to frequent ‘‘nontargets’’ (digits 0–6, 8–9) but withhold responses to infrequent ‘‘targets’’ (the digit 7). We compared the behavioral performance and electroencephalographic waves between the high and low trait anxiety groups during states of “mind wandering” (fail to withhold a response to the target number) and being “on-task” (correctly withhold a response to the target number). Results showed that a larger late positive component (LPC, 400–950 ms) was elicited when participants were “on task” than when they were mind wandering. Additionally, a larger late slow waveform (LSW, 950–1050 ms) was elicited in the high trait anxiety group than in the low trait anxiety group. Moreover, there was a positive correlation between self-reported trait anxiety scores and the LSW amplitudes during mind wandering. It was proposed that the effect of trait anxiety on the cognitive neural mechanism underlying attentional processing was primarily reflected in a later process involving the redistribution of cognitive resources.

Preoperative Virtual Reality to Expose Patients With Breast Cancer to the Operating Room Environment: Feasibility and Pilot Case Series Study.

Clinically elevated preoperative distress and anxiety are common among patients undergoing cancer surgery. Preoperative interventions have been developed to mitigate this distress and anxiety but are inconsistent in efficacy and feasibility for broad implementation. This preliminary pilot study aims to assess the feasibility and utility of a newly developed virtual reality (VR) intervention to expose patients awaiting breast cancer surgery to the operating room environment and a simulation of anesthetic induction. Patients undergoing breast cancer surgery (N=7) were assigned to the VR intervention or control (treatment as usual) group and completed self-report measures of distress and anxiety before surgery, on the day of surgery, and after surgery (5 and 30 d postoperatively). Those in the intervention group trialed the VR simulation 1 to 2 weeks preoperatively and provided qualitative and quantitative feedback. We assessed the feasibility of recruitment capability and study design and evaluated participants' impressions of the intervention using self-report rating scales and open-ended questions. We also descriptively examined distress and anxiety levels throughout the duration of the study. Recruitment occurred between December 2021 and December 2022 and progressed slowly (rate: 1 participant/7 wk on average; some hesitancy because of stress and being overwhelmed). All participants who consented to participate completed the entire study. All participants were female and aged 56 (SD 10.56) years on average. In total, 57% (4/7) of the participants were assigned to the intervention group. On average, intervention participants spent 12 minutes engaged in the VR simulation. In general, the intervention was rated favorably (eg, clear information, enjoyable, and attractive presentation; mean% agreement 95.00-96.25, SD 4.79-10.00) and as helpful (mean% agreement 87.50, SD 25.00). Participants described the intervention as realistic (eg, "It was realistic to my past surgical experiences"), impacting their degree of preparedness and expectations for surgery (eg, "The sounds and sights and procedures give you a test run; they prepare you for the actual day"), and having a calming or relaxing effect (eg, "You feel more relaxed for the surgery"). This preoperative VR intervention demonstrated preliminary feasibility among a sample of patients undergoing breast cancer surgery. Results and participant feedback will inform modifications to the VR intervention and the study design of a large-scale randomized controlled trial to examine the efficacy of this intervention. ClinicalTrials.gov NCT04544618; https://clinicaltrials.gov/study/NCT04544618.

Efficacy of the use of video games on mood, anxiety and depression in stroke patients: preliminary findings of a randomised controlled trial

BackgroundIn the different published studies, there is no consensus on the efficacy of virtual reality as an adjuvant treatment of mood states.AimThe aim of this study is to evaluate the impact of no immersive virtual reality with the Nintendo Switch device in rehabilitation treatment on mood, anxiety and depression in stroke patients admitted to neurorehabilitation units.MethodsFifty-eight patients admitted to neurorehabilitation units underwent a 1:3 multicentre randomised clinical trial. The intervention group consisted of 17 patients and the control group of 41 patients. The intervention group performed 6 virtual reality sessions together with the conventional treatment, and the control group performed only the conventional rehabilitation sessions. Primary and secondary clinical outcomes were measured before and six weeks after the intervention.ResultsComparing the intervention group and control group, the anxiety levels of the intervention group decreased compared to the results observed in the control group (p = 0.01), as did the dependence of the intervention group (0.015). On the other hand, the results obtained after the intervention by the control group for anxiety (0.479) and depression (0.292) were not statistically significant.ConclusionRehabilitation VR used as an adjuvant treatment to conventional treatment has a beneficial impact on the neurological status and state of anxiety of stroke patients admitted to neurorehabilitation units.Trial registrationRegistered in the https://clinicaltrials.gov/ repository (NTC NCT05143385). Protocol registration date 7 October 2021, retrospectively registered.

A cross-sectional study exploring the relationship between symptoms of anxiety/depression and P50 sensory gating in adult patients diagnosed with chronic fatigue syndrome/myalgic encephalomyelitis.

Chronic fatigue syndrome (CFS) is a clinical disease that affects multiple body systems. It is characterized by persistent or recurring fatigue, which may be linked to immune, neuroendocrine, and energy metabolism dysfunctions. Individuals with CFS may experience pain, sleep disorders, anxiety, and depression. This research analyzed the fundamental characteristics of anxiety/depression symptoms in patients with CFS and investigated the association between these symptoms and the P50 SG (sensory gate) ratio. Two hundred and forty-nine subjects fulfilled the CDC-1994 criteria for CFS and were included in the study. The subjects successively completed the Symptom CheckList-90-Revised (SCL-90-R), Hamilton Anxiety Rating Scale-14 (HAMA-14), and Hamilton Depression Rating Scale-24 (HAMD-24). Auditory-evoked potential P50 were measured using the 128-lead-electroencephalograph. According to HAMA and HAMD, 17.3% (n = 43) of the patients did not exhibit anxiety/depression, with a threshold score of 7 and 7 for HAMA and HAMD. When the threshold score was 14 and 20 respectively, 43.3% (n = 108) of the patients did not exhibit anxiety/depression. The SCL-90-R results indicated that 69.5% (n = 173) of these individuals with the score arranging from 0 to 160 did not present mental problems. There was a correlation between somatization scores and P50 SG ratio in the overall sample and no anxiety or depression (NAOD) group delimited by 14 and 20, respectively, (p < 0.05). Regression analysis showed that anxiety and depression were risk factors associated with an abnormal P50 SG ratio. A significant correlation exists between the P50 SG ratio and clinical symptoms such as fatigue, anxiety, and depression. Abnormalities in brain function among patients with CFS may play a crucial role in the pathogenesis of the condition, leading to their classification as being prone to functional neurological disorders. The P50 SG ratio cannot be used as a diagnostic marker for CFS but show some significance on the mechanism, classification, treatment, and prognosis of CFS.