Anxiety-depressive States Research Articles

A Controlled Comparative Trial of a Combination of Opipramol and Clomipramine and a Higher Dose of Clomipramine Alone

Sixty patients suffering from mixed anxiety depressive states were admitted to a comparative controlled clinical trial of a free combination of opipramol 50 mg and clomipramine 10 mg and clomipramine 25 mg. A double-dummy technique was used to ensure blindness and both regimes were administered three times daily. A stratified randomization technique was employed but this did not work effectively as far as severity was concerned producing some imbalance in the groups. Thirty-one patients received the combination therapy and 29 clomipramine alone. Twenty-eight patients on the combination regime and 24 on clomipramine alone completed the study. Amongst the completers the total score, on a 17 symptom rating scale, fell from 19·6 to 6·6 in the combination group and from 23·6 to 9·3 in the clomipramine alone group after 4 weeks treatment. Significantly more side-effects, especially dry mouth, were seen in the clomipramine alone group. After 2 weeks the opipramol/clomipramine regime was significantly more effective in the relief of anxiety whereas the clomipramine higher dose regime brought about a significantly greater improvement in the symptom depressed mood.

Clinical Response to Amitriptyline and Chlordiazepoxide-Amitriptyline (Limbitrol®) in Anxiety-Depressive States: A Double-Blind Study

Clinical Response to Amitriptyline and Chlordiazepoxide-Amitriptyline (Limbitrol®) in Anxiety-Depressive States: A Double-Blind Study

Comparison of Chlordiazepoxide‐Amitriptyline Combination with Amitriptyline Alone in Anxiety‐Depressive States

The Journal of Clinical Pharmacology and New DrugsVolume 11, Issue 6 p. 456-460 Comparison of Chlordiazepoxide-Amitriptyline Combination with Amitriptyline Alone in Anxiety-Depressive States HENRY P. HARE JR. M.D., HENRY P. HARE JR. M.D. San Antonio, TexasSearch for more papers by this author HENRY P. HARE JR. M.D., HENRY P. HARE JR. M.D. San Antonio, TexasSearch for more papers by this author First published: November‐December 1971 https://doi.org/10.1177/009127007101100610Citations: 4AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume11, Issue6November‐December 1971Pages 456-460 RelatedInformation

The quantitative relationship between anxiety-depressive states and the triiodothyronine I-131 binding capacity of alpha and beta globulins—A biochemical test and graphic index for investigation of protein-hormonal physiology in psychiatric disorders

The quantitative relationship between anxiety-depressive states and the triiodothyronine I-131 binding capacity of alpha and beta globulins—A biochemical test and graphic index for investigation of protein-hormonal physiology in psychiatric disorders

SEROLOGIC INDICES OF MENTAL DISORDERS.

Back to table of contents Previous article Next article ArticleNo AccessSEROLOGIC INDICES OF MENTAL DISORDERSHOWARD D. KURLANDHOWARD D. KURLANDSearch for more papers by this authorPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.121.9.909AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail PDFThis content is only available as a PDF. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited ByJournal of Psychiatric Research, Vol. 9, No. 1The quantitative relationship between anxiety-depressive states and the triiodothyronineI-131 binding capacity of alpha and beta globulins—A biochemical test and graphic index for investigation of protein-hormonal physiology in psychiatric disordersJournal of Psychiatric Research, Vol. 6, No. 2 Volume 121Issue 9 March 1965Pages 909-911 Metrics PDF download History Published online 1 April 2006 Published in print 1 March 1965