Anxiety-depressive Spectrum Research Articles

P-1467 - Relationship between women infertility and depression, anxiety and stress disorders

Introduction According to WHO data about 60–80 million people around the world suffer from infertility. This problem causes huge negative impact on family life. Forty percent of women with infertility experience various mental disorders. Aims/objectives: Investigation of anxiety-depressive spectrum disorders in women with infertility. Assessment of impact of women infertility on self-esteem and certain aspects of life. Development of recommendations on mental health services for women, experiencing infertility problems. Methods Sixty women at the age of 21 to 36 years, experiencing infertility problems for maximum period of 60 months participated in the study. Anxiety, depression and stress rates were assessed using Depression, Anxiety and Stress Scale - DASS-21, the level of self-esteem was determined with Rosenberg Self-Esteem Scale. Data was analyzed using SPSS 16.0. Results Such factors as education, occupation, religious beliefs, and accessibility of proper medical services were determined to have significant impact on depression, anxiety and stress rates as well as on self-esteem and satisfaction with life of women with infertility. Conclusions Screening for early detection of mental health problems, psychological counseling and family therapy for couples encountering infertility problems was recommended.

P-742 - Cognitive disturbances in the primary health care patients suffering with organic and anxiety-depressive disorders

Differential evaluation of cognitive, anxiety and depressive disturbances presents an important issue in clinical qualification of the patients attending primary health care. The paper studies the feasibility of the psychometric tests application for this purpose. A total of 60 patients (10 men, 50 female) aged from 18 to 75, that were on treatment in a district policlinic, were studied. The first group included 23 patients with anxiety-depressive spectrum disorders (ADSD), the second group - 17 patients with mild organic mental disorders (MOMD), the third group - 20 patients with combination of these disorders (ADSD+MOMD). The fourth group consisted of 26 healthy persons. The following psychometric instruments were used: Screening Questionnaire for Identifying Risk of Affective Disorder Spectrum, Hospital Anxiety and Depression Scale, Beck Depression Inventory, the methods “10 Words List Recall”, “Six Figures Recall”, and “Objects Exclusion”. Results of the study showed, that these tests help to improve diagnosing and differentiation of cognitive impairments in ADSD, MOMD, and ADSD+MOMD. In particular, the patients with MOMD are characterized by disorders of verbal and visual image memory, decrease of internal determination of estimates, and narrowing of the range of the meaning articulation. The patients with ADSD have no symptoms of the cognitive deficit changes, but they do have the cognitive style disturbances with some decrease of the working memory capacity, the trend to the decrease of the internal selection consistency and rather good ability to articulate the meanings. In the cases of ADSD+MOMD there is a combination of the above specified traits.

Objective: to specify the frequency and pattern of mental disorders in patients with rheumatoid arthritis (RA) and their association with a number of demographic parameters, stressors, inflammatory activity, duration of RA and its therapy, pain, and concomitant cardiovascular diseases (CVD).Subject and methods. One hundred and sixteen patients with verified RA were examined; 86% were women with a median age of

Objective: to specify the frequency and pattern of mental disorders in patients with rheumatoid arthritis (RA) and their association with a number of demographic parameters, stressors, inflammatory activity, duration of RA and its therapy, pain, and concomitant cardiovascular diseases (CVD).Subject and methods. One hundred and sixteen patients with verified RA were examined; 86% were women with a median age of

S45-02 - Chronic stress and anxiety-depressive spectrum disorders in patients of phoniatric practice

ObjectivesTo research the influence of stress factors on the development and circuit of voice disorders in their relation to anxiety and depressive spectrum.AimesTo analyze the extent to which the anxiety and depressive disorders are spreading among the patients with voice dysfunctions, to determine the variety of factors for psychological traumatic experience, and to distinguish the variety of anxiety and depressive disorders.MethodsThe Hospital Anxiety and Depression Rating Scale (HADS), the projective psychological tests.Preliminary HADS screening was conducted among 180 patients. More than half of the patients (57.5%) had high risk of anxiety and depressive disorders. 55 patients (44 women, 13 men, age of 18–70) with voice disorders and the positive results of screening were included to the study. Patients underwent a complete otolaryngologic examination and were grouped into organic voice pathology (34.5%) and non-organic voice pathology (65.5%). In accordance with ICD-10, anxiety and depressive disorders were diagnosed in 48 (87%) patients. In most cases (98.7%) the phoniatric pathology developed in chronic stress conditions. The prevailed chronic stress factors that provoked both anxiety-depressive spectrum disorders and voice pathology were inability to reach pre-set social goal (65.4%), ethical conflict (18.2%) and lack of external control factors (16.4%). Professional factor was also important as 38.2% of the group claimed heavy voice load at work.Chronic stress factors play significant provoking role in the development of voice and anxiety-depressive spectrum disorders, which should be taken into account to design diagnostic and therapeutic tactics for patients with voice pathology.

P03-434 - Chronic stress and anxiety-depressive spectrum disorders in patients of phoniatric practice

ObjectivesTo research the influence of stress factors on the development and circuit of voice disorders in their relation to anxiety and depressive spectrum.AimsTo analyze the extent to which the anxiety and depressive disorders are spreading among the patients with voice dysfunctions, to determine the variety of factors for psychological traumatic experience, and to distinguish the variety of anxiety and depressive disorders.MethodsThe Hospital Anxiety and Depression Scale (HADS), the projective psychological tests.ResultsPreliminary HADS screening was conducted among 180 patients. More than half of the patients (57.5%) had high risk of anxiety and depressive disorders. 55 patients (44 women, 13 men, age of 18–70) with voice disorders and the positive results of screening were included to the study. Patients underwent a complete otolaryngologic examination and were grouped into organic voice pathology (34.5%) and non-organic voice pathology (65.5%). In accordance with ICD-10, anxiety and depressive disorders were diagnosed in 48 (87%) patients. In most cases the phoniatric pathology developed in chronic stress conditions. The prevailed chronic stress factors that provoked both anxiety-depressive spectrum disorders and voice pathology were inability to reach pre-set social goal (65.4%), ethical conflict (18.2%) and lack of external control factors (16.4%). Professional factor was also important as 38.2% of the group claimed heavy voice load at work.ConclusionChronic stress factors play significant provoking role in the development of voice and anxiety-depressive spectrum disorders, which should be taken into account to design diagnostic and therapeutic tactics for patients with voice pathology.

Variants of psychiatric disorders in patients with systemic lupus erythematosus

Objective. To analyze prevalence and structure of psychiatric disorders in pts with systemic lupus erythematosus (SLE) examining in the Institute of rheumatology of RAMS. Material and methods. 115 pts with SLE with median age 34 [24; 45] years and median disease duration 8 [4; 17] years were included. SLE activity was assessed with SLEDAI. Psychiatric disorders were diagnosed by a psychiatrist according to ICD-10 using some psychiatric and psychological scales. Results. Psychiatric disorders were revealed in 76 from 115 (66%) pts. Anxiety-depressive spectrum disorders prevailed (83%): depressive episode (40%), adjustment disorders (24%), generalized anxiety disorder (10%), dysthymia (9%). Severe cognitive dysfunction was revealed in 7% of pts. Pts with and without psychiatric disorders did not significantly differ in age, sex, duration and activity of the disease, duration of treatment and cumulative dose of prednisolone and cytotoxic drugs. Conclusion. Psychiatric disorders are frequent in pts with SLE (66%). Anxiety-depressive disorders prevail among them (83%). Relationship between SLE and psychiatric disorders requires further examination.

What is the genetic relationship between anxiety and depression?

Anxiety and depression share a long, close history in psychiatric nosology and treatment. The anxiety disorders, individually and as a group, exhibit remarkably high rates of comorbidity with each other and with major depression. Analyses done in large-scale epidemiologic surveys have identified major patterns of phenomenological overlap between these conditions. Researchers have tested hypotheses of shared genetic etiologies as a potential basis of this relationship. In general, available family studies have found mixed evidence for co-aggregation of anxiety and depressive disorders, while twin studies more definitively indicate that shared genetic risk factors largely account for this comorbidity. Some of this appears to be accounted for by genetic variation in personality traits that broadly predispose to anxiety and depression. Molecular genetic studies of these conditions, though too early to draw firm conclusions, thus far provide tentative support for specific genetic loci that may generally influence susceptibility across the anxiety-depressive spectrum.