Papio Anubis Research Articles

Secondary Compounds and Food Selection by Olive Baboons (Papio anubis) in a Wildlife Park

Secondary Compounds and Food Selection by Olive Baboons (Papio anubis) in a Wildlife Park

Composition, Relative Abundance, and Diversity of Medium and Large Mammals in Tirba Lake Awi Zone, Ethiopia

Understanding the diversity, abundance, and habitat preferences of the fauna is essential for determining the status and suggesting effective conservation actions. A study was conducted in Tirba Lake Awi zone, Ethiopia, to evaluate the wealth, diversity, and composition of the medium and large mammal communities. It is also important to consider how these parameters differ from one habitat type to another and from one season to another. Researchers collected data using a transect method. As a result of the study, 330 individuals and 11 different species of mammals were identified across four orders and six families. The result shows that globally threatened species like the Leopard (Panthera pardus) were included. In terms of seasonal variation in wild mammal abundance, the difference was statistically significant (P $$\le$$ 0.001). A total of 330 ± 26.2 wild mammals were recorded, of which 180 ± 11 (55%) were observed during the wet season and 150 ± 6.5 (45%) during the dry season. Olive Baboons (Papio Anubis) accounted for 30.61% of the 11 mammalian species with 101 individuals, followed by Vervet monkeys (Cercopithecus aethiops) with 16.67% and 55 individuals, respectively. Mammalian populations were statistically significant among habitat types, with the highest similarity index (SI = 0.8) observed between open forests and shrubland, followed by shrubland adjacent to Cliff sites (SI = 0.7). The shrubland habitat type (Hʹ = 1) supports the greatest diversity of mammalian species, followed by the open forest habitat type (Hʹ = 0.8). In terms of diversity among habitat types, dense forests had the lowest Hʹ value (0.5). Based on the species similarity index, open forest and shrubland shared the most similarity of mammalian species (Sl = 0.8), while shrubland and cliff sites hosted the least similar species (SI = 0.7). To conclude, our findings contribute significantly to the conservation of Ethiopia's mammal populations. As a result of our findings, managers of the area will be able to make effective conservation decisions, and researchers wishing to conduct related studies will be able to use the findings as a baseline for their research. Studies in the study area have revealed that anthropogenic factors interact with the mammals in the area, putting them at risk. It is imperative that these animals are protected through an urgent conservation program.

Abstract 6310: Phylogenetic conservation of primate Trop-2 underscores favorable pharmacokinetics and lack of toxicity of the cancer-selective Hu2G10 anti-Trop-2

Abstract Trop-2 is a transmembrane signal transducer that activates growth-signaling networks that converge on Akt, ERK, Cyclin D1, NFkB (1). We discovered that Trop-2 cleavage by ADAM10 is an activator switch of cancer growth and metastatic diffusion (2) and exposes novel target epitopes that are inaccessible in the unprocessed wtTrop-2. The Hu2G10 mAb selectively binds these epitopes with an affinity that is ≈10,000-fold higher than for the unprocessed molecule. To validate a reliable model for Hu2G10 binding in vivo, we explored Trop-2 phylogenetic conservation in primates. Pan troglodites (chimpanzee), Papio anubis (baboon), Macaca mulatta/fascicularis (Rhesus/Cynomolgous), Callithrix jaccus (marmoset) TROP2/TACSTD2 sequences were compared. The only difference between Pan troglodytes and human Trop-2 is one additional leucine in the Pan leader peptide, making the mature Trop-2 identical to that in man. The Macaca mulatta/fascicularis Trop-2 sequences are 97% identical, 100% similar to the human sequence. Three-dimensional modeling revealed polymorphic residues usage versus activation-driven structural rearrangement of Trop-2. COS-7 and HEK-293 cells transfected with individual primate Trop-2 showed efficient recognition by Hu2G10 in all tested species. Immunohistochemistry analysis of normal Macaca tissues showed Trop-2 expression patterns essentially corresponding to the human ones. IV injected Hu2G10 at doses of 5 to 10 mg/kg was well tolerated by Cynomolgous monkeys. No neurological, respiratory, digestive and urinary adverse effects were observed, and no body-weight loss occurred during the 28-day observation. No alterations of blood monocyte, neutrophil and basophil counts nor significant changes in biochemical parameters were detected. A pharmacokinetic (PK), study was carried out. Serum concentration of Hu2G10 was determined using anti-idiotypic antibody-based ELISA assays. At the higher dosing of 10 mg/kg Hu2G10 serum values reached a peak 2-hour after the injection (13281±4686 ng/ml). The concentration of Hu2G10 then diminished gradually, and reached baseline levels on day 21. The serum concentration peak of 5 mg/kg Hu2G10 was 5759±1729 ng/ml, and reached baseline levels on day 14. Thus, Hu2G10 is stable in plasma, and is detectable in the circulation up to three weeks after the infusion (t1/2=6.5 days). Taken together, these findings validate primate models as reliable for assessing Hu2G10 in vivo toxicity and PK. The lack of toxicity and favorable PK parameters candidate the cancer specific Hu2G10 as first-in-class anti-Trop-2 mAb. (1) Guerra E. et al., Oncogene 41:1795-1808 (2022).(2) Trerotola M. et al., Neoplasia 23: 415-428 (2021). Citation Format: Saverio Alberti, Martina Ceci, Ludovica Pantalone, Marco Trerotola, Emanuela Guerra. Phylogenetic conservation of primate Trop-2 underscores favorable pharmacokinetics and lack of toxicity of the cancer-selective Hu2G10 anti-Trop-2. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6310.

The Isolation and In Vitro Differentiation of Primary Fetal Baboon Tracheal Epithelial Cells for the Study of SARS-CoV-2 Host-Virus Interactions.

The mucociliary airway epithelium lines the human airways and is the primary site of host-environmental interactions in the lung. Following virus infection, airway epithelial cells initiate an innate immune response to suppress virus replication. Therefore, defining the virus-host interactions of the mucociliary airway epithelium is critical for understanding the mechanisms that regulate virus infection, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Non-human primates (NHP) are closely related to humans and provide a model to study human disease. However, ethical considerations and high costs can restrict the use of in vivo NHP models. Therefore, there is a need to develop in vitro NHP models of human respiratory virus infection that would allow for rapidly characterizing virus tropism and the suitability of specific NHP species to model human infection. Using the olive baboon (Papio anubis), we have developed methodologies for the isolation, in vitro expansion, cryopreservation, and mucociliary differentiation of primary fetal baboon tracheal epithelial cells (FBTECs). Furthermore, we demonstrate that in vitro differentiated FBTECs are permissive to SARS-CoV-2 infection and produce a potent host innate-immune response. In summary, we have developed an in vitro NHP model that provides a platform for the study of SARS-CoV-2 infection and other human respiratory viruses.

Individual differences in coping styles and associations with social structure in wild baboons (Papio anubis)

Individual differences in coping styles and associations with social structure in wild baboons (Papio anubis)

Lethal Aggression in Captive Monkeys

Establishing the characteristics of monkey lethal aggression, assessing the age and sex of aggressors and victims, and the nature of the aggressors' actions seems necessary to identify the evolutionary roots of cases of human lethal aggression. In addition, the study of the features of lethal aggression can be considered as a condition for the development of measures aimed at preventing its manifestations in captive monkeys. The aim of the study is to study the species-specific features of lethal aggression in captive macaques, baboons and guenons. An analysis was made of cases of intra-group lethal aggression that occurred over a 10-year period in Rhesus macaques (Macaca mulatta), Crab-eathing macaques (Macaca fascicularis), Pig-tail macaques (Macaca nemestrina), Green monkeys (Chlorocebus aethiops), Hamadryas baboons (Papio hamadryas), Anubis baboons (Papio anubis) kept by social groups. It has been established that cases of lethal aggression are observed in all 6 studied species of monkeys. It was shown that in groups consisting of adult males, the highest frequency of cases of lethal aggression was noted in Rhesus macaques, and the lowest in Hamadryas baboons. Species-specific differences were found in the nature of lethal aggression in monkey family groups consisting of males, females, infants, and adolescents. It has been established that in Hamadryas baboons, Anubis baboons and Pig-tail macaques, that is, in species with pronounced sexual dimorphism in body size and social status, the main form of lethal aggression in family groups is infanticide committed by a single sexually mature male. In Rhesus monkeys, Crab-eathing macaques and Green monkeys, that is, those species that are characterized by relatively mild sexual dimorphism in body size and social status, the predominant form of lethal aggression in family groups is the collective actions of females aimed at young and adult members of the group.

Age- and sex-related differences in baboon (Papio anubis) gray matter covariation

Age-related changes in cognition, brain morphology, and behavior are exhibited in several primate species. Baboons, like humans, naturally develop Alzheimer's disease-like pathology and cognitive declines with age and are an underutilized model for studies of aging. To determine age-related differences in gray matter covariation of 89 olive baboons (Papio anubis), we used source-based morphometry (SBM) to analyze data from magnetic resonance images. We hypothesized that we would find significant age effects in one or more SBM components, particularly those which include regions influenced by age in humans and other nonhuman primates (NHPs). A multivariate analysis of variance revealed that individual weighted gray matter covariation scores differed across the age classes. Elderly baboons contributed significantly less to gray matter covariation components including the brainstem, superior parietal cortex, thalamus, and pallidum compared to juveniles, and middle and superior frontal cortex compared to juveniles and young adults (p < 0.05). Future studies should examine the relationship between the changes in gray matter covariation reported here and age-related cognitive decline.

Ecology and age, but not genetic ancestry, predict fetal loss in a wild baboon hybrid zone.

Pregnancy failure represents a major fitness cost for any mammal, particularly those with slow life histories such as primates. Here, we quantified the risk of fetal loss in wild hybrid baboons, including genetic, ecological, and demographic sources of variance. We were particularly interested in testing the hypothesis that hybridization increases fetal loss rates. Such an effect would help explain how baboons may maintain genetic and phenotypic integrity despite interspecific gene flow. We analyzed outcomes for 1020 pregnancies observed over 46 years in a natural yellow baboon-anubis baboon hybrid zone. Fetal losses and live births were scored based on records of female reproductive state and the appearance of live neonates. We modeled the probability of fetal loss as a function of a female's genetic ancestry (the proportion of her genome estimated to be descended from anubis [vs. yellow] ancestors), age, number of previous fetal losses, dominance rank, group size, climate, and habitat quality using binomial mixed effects models. Female genetic ancestry did not predict fetal loss. Instead, the risk of fetal loss is elevated for very young and very old females. Fetal loss is most robustly predicted by ecological factors, including poor habitat quality prior to a home range shift and extreme heat during pregnancy. Our results suggest that gene flow between yellow and anubis baboons is not impeded by an increased risk of fetal loss for hybrid females. Instead, ecological conditions and female age are key determinants of this component of female reproductive success.

Crop Loss and Damage by Primate Species in Southwest Ethiopia

Crop damage is a major form of human-primate conflict that not only affects the livelihoods of farmers living close to forest areas but also threatens nonhuman primate conservation. This study aimed to investigate the causes of crop loss and foraging by nonhuman primates in southwest Ethiopia. For the purpose of gathering data, we used a questionnaire and direct observation. We employed simple random sampling techniques to select villages and respondents. From the nine selected villages, a total of 130 household samples were identified for the questionnaire. The primates responsible for crop damage were olive baboons and grivet monkeys. Maize, barley, teff, potatoes, sorghum, and other crops were among those foraged by the nonhuman primate species. Farmland close to the woodland boundary suffered more damage than farmland further away. The total amount of maize damaged by the olive baboons and grivet monkeys in the selected kebeles varied significantly. The majority of the respondents used guarding, and a few of them used scarecrows to protect crops from damage by primates. The highest crop damage occurred in the Atiro Tigre and Arigno Gefere villages, while the lowest occurred in the Sedecha villages. The flowering stage of the maize suffered the most, and the seedling stage suffered the least, from grivet monkeys foraging. The growth of crops that are less edible to nonhuman primates, especially on the forest edges, would lessen crop damage.

Palaeopathological and demographic data reveal conditions of keeping of the ancient baboons at Gabbanat el-Qurud (Thebes, Egypt).

Since predynastic times, baboons (Papio hamadryas and Papio anubis) were important in ancient Egypt for ritual and religious purposes. These species did not occur naturally in Egypt and therefore had to be imported, but little is known about their exact provenance and the conditions in which they were kept through time. Here, we analyse the skeletal remains of a collection of baboon mummies coming from Thebes (Egypt), representing a minimum of 36 individuals, from a palaeopathological and demographic point of view. The pathological cases are described, figured where relevant, and the discussion attempts to understand their aetiology. The prevalence of the different types of deformations and pathologies is compared with that of other captive baboon populations from more or less contemporary (Tuna el-Gebel and Saqqara) or older (predynastic Hierakonpolis) sites. This is combined with observations on the age and sex distribution and the proportion of hamadryas and anubis baboons to draw conclusions about the conditions of keeping, possible breeding on-site, provenance of the animals and the trade routes used for import. As in Tuna el-Gebel and Saqqara, the baboons from Gabbanat el-Qurud suffered from numerous metabolic diseases due to chronic lack of sunlight and an unbalanced diet. This and the demographic data suggest that there was a local breeding population derived from animals captured downstream from the Sudanese Nile Valley (for anubis) and from the Horn of Africa or the southern part of the Arabian Peninsula (for hamadryas). A new series of radiocarbon dates is provided, placing the baboons from Gabbanat el-Qurud between the end of the Third Intermediate Period and the beginning of the Late Period.

Heavy Metals Accumulation in Feaces of Wildlife around Ogun River in Old Oyo National Park, Nigeria

Knowledge of bioaccumulation of heavy metals (HMs) in wildlife of our national parks is poor. This study evaluated wildlife dungs in Old Oyo National Park (OONP) for bioaccumulation of arsenic (As), cadmium (Cd), chromium (Cr), cupper (Cu), lead (Pb), zinc (Zn), nickel (Ni) and cobalt (Co) using standard procedures. Composite dung samples of kob (K), cane rat (KR), crocodile (C), pattas monkey (PM), olive baboon (OB), civet cat (CC) and western hartebeest (WH) were collected along River Ogun. Concentrations were significantly different (α

Mitigating crop raiding by forest elephants and baboons at Kibale National Park

AbstractIn Africa, most protected forests are in densely human‐dominated landscapes where human–wildlife conflict is intense. We documented farmer perceptions and responses to crop‐raiding wildlife from Kibale National Park, Uganda. Crop raiding was mostly (95%) by baboons (Papio anubis) and elephants (Loxodonta africana). While the financial loss caused by baboons and elephants did not differ, elephants were perceived as more damaging. Guarding and trenches were perceived as the most effective deterrent strategies for baboons and elephants, respectively. Distance from the park boundary and household income were significantly associated with a greater likelihood of crop raiding. Distance from the park, household head age and the species that raided crops, influenced whether a household applied one or more deterrent strategies. Households headed by women or older adults were most vulnerable, experiencing greater losses to raiding. Patterns of human–wildlife conflict around Kibale forest are complex, but the extent of crop damage was mostly determined by distance from the park and farm socio‐economic status and thus their ability to mitigate or deter raiding. Managing crop raiding requires collaboration between the park and affected farmers to ensure that mutually managed deterrent methods, such as trenching (elephants) and guarding (baboons), are effectively shared, applied and maintained.

No evidence for yaws infection in a small‐scale cross‐sectional serosurvey in Ghanaian monkeys

Treponema pallidum (TP) is a spirochaete bacterium with subspecies that in humans cause syphilis (subsp. pallidum), bejel (subsp. endemicum) and yaws (subsp. pertenue; TPE). The latter is target for eradication which requires detailed information on yaws epidemiology. It has been shown that African nonhuman primates (NHPs) are infected with TPE strains that are closely related to the human infecting yaws bacterium. While human yaws infection is known to be endemic in Ghana, there is a paucity of information regarding TPE infection of Ghana's native NHPs. The objective was to perform a small-scale cross-sectional serological screening for antibodies against TPE in Ghanaian monkeys. Due to the reports of TPE-infected NHPs from neighbouring Côte d'Ivore, we hypothesised that monkeys in Ghana are infected with TPE and, therefore, are seropositive for antibodies against-Treponema. We sampled blood from 37 NHPs representing four species: Erythrocebus patas (16/37) 43.2%, Papio anubis (15/37) 40.5%, Chlorocebus sabaeus (3/37) 8.1% and Cercopithecus mona (3/37) 8.1%. Samples were tested using the NHP validated treponemal test ESPLINE TP. All 37 animals were seronegative for yaws infection. We cannot exclude yaws infection in NHPs in Ghana at this point. Our study, in combination with the absence of reports of clinically infected NHPs in a yaws endemic country is, however, supportive for the current thinking that interspecies infection with TPE is extremely rare. This is an important finding for the current ongoing yaws eradication campaign.

Molecular Detection and Characterization of Herpesvirus Papio 2 (HVP2) in Wild-Caught Olive Baboons from Selected Regions in Kenya

Molecular Detection and Characterization of Herpesvirus Papio 2 (HVP2) in Wild-Caught Olive Baboons from Selected Regions in Kenya

Cerebral Activity in Female Baboons (Papio anubis) During the Perception of Conspecific and Heterospecific Agonistic Vocalizations: a Functional Near Infrared Spectroscopy Study

The “voice areas” in the superior temporal cortex have been identified in both humans and non-human primates as selective to conspecific vocalizations only (i.e., expressed by members of our own species), suggesting its old evolutionary roots across the primate lineage. With respect to non-human primate species, it remains unclear whether the listening of vocal emotions from conspecifics leads to similar or different cerebral activations when compared to heterospecific calls (i.e., expressed by another primate species) triggered by the same emotion. Using a neuroimaging technique rarely employed in monkeys so far, functional Near Infrared Spectroscopy, the present study investigated in three lightly anesthetized female baboons (Papio anubis), temporal cortex activities during exposure to agonistic vocalizations from conspecifics and from other primates (chimpanzees—Pan troglodytes), and energy matched white noises in order to control for this low-level acoustic feature. Permutation test analyses on the extracted OxyHemoglobin signal revealed great inter-individual differences on how conspecific and heterospecific vocal stimuli were processed in baboon brains with a cortical response recorded either in the right or the left temporal cortex. No difference was found between emotional vocalizations and their energy-matched white noises. Despite the phylogenetic gap between Homo sapiens and African monkeys, modern humans and baboons both showed a highly heterogeneous brain process for the perception of vocal and emotional stimuli. The results of this study do not exclude that old evolutionary mechanisms for vocal emotional processing may be shared and inherited from our common ancestor.

DIVERSITY AND THREATS OF MEDIUM AND LARGE-SIZED MAMMALS IN AMORO FOREST, WEST GOJJAM ZONE, AMHARA, ETHIOPIA

The objective of this study was to assess the species composition, and relative abundance and to determine major threats of medium and large-sized mammals in Amoro Forest. Line transects surveying and indirect surveys method (including fresh tracks, scats, hair, spines, and burrows) were used to survey mammalian diversity. A survey was conducted in the early morning from 6:00 to 10:00 and late afternoon from 16:00 to 19:00. Key interviews and direct site observationswere carried out to assess the major threat of mammals in the study area. A total of 12 species of medium and large-sized mammals belonging to six orders and eight families were recorded. Porcupine (Hystrix cristata), Vervet monkey (Chlorocebus aethiops), and Olive baboon (Papio anubis) were among the medium-sized mammals while, Spotted hyena (Crocuta crocuta), Leopard (Panthera pardus) and Common duiker (Sylvicapra grimmia) were among the large-sized mammals observed in the study area. Shannon–Wiener Index values were low (H′ = 1.666) whereas, the Simpson's index (1-D) of diversity showed the highest species diversity (0.761) in the study area. Species richness and evenness varied from habitat to habitat in the Amoro forest. Land degradation and different anthropogenic activities such as; illegal logging of trees, overgrazing, agricultural activities, and human-wildlife conflicts were the foremost observed threats to the mammals in the study area. Community participation and awareness creation are very important to limit the impact of anthropogenic activities threatening wildlife.

Global abundance of short tandem repeats is non-random in rodents and primates

BackgroundWhile of predominant abundance across vertebrate genomes and significant biological implications, the relevance of short tandem repeats (STRs) (also known as microsatellites) to speciation remains largely elusive and attributed to random coincidence for the most part. Here we collected data on the whole-genome abundance of mono-, di-, and trinucleotide STRs in nine species, encompassing rodents and primates, including rat, mouse, olive baboon, gelada, macaque, gorilla, chimpanzee, bonobo, and human. The collected data were used to analyze hierarchical clustering of the STR abundances in the selected species.ResultsWe found massive differential STR abundances between the rodent and primate orders. In addition, while numerous STRs had random abundance across the nine selected species, the global abundance conformed to three consistent < clusters>, as follows: <rat, mouse>, <gelada, macaque, olive baboon>, and <gorilla, chimpanzee, bonobo, human>, which coincided with the phylogenetic distances of the selected species (p < 4E-05). Exceptionally, in the trinucleotide STR compartment, human was significantly distant from all other species.ConclusionBased on hierarchical clustering, we propose that the global abundance of STRs is non-random in rodents and primates, and probably had a determining impact on the speciation of the two orders. We also propose the STRs and STR lengths, which predominantly conformed to the phylogeny of the selected species, exemplified by (t)10, (ct)6, and (taa4). Phylogenetic and experimental platforms are warranted to further examine the observed patterns and the biological mechanisms associated with those STRs.

Effects of environmental factors on the distribution of flagship species in Bomfobiri Wildlife Sanctuary, Kumawu, Ghana: Implications for conservation and ecotourism development

AbstractSustainable ecotourism development and conservation depend on understanding factors that affect flagship species. This study analysed environmental factors and their effects on flagship species: African buffalo (Syncerus caffer), red‐river hog (Potamochoerus porcus), olive baboon (Papio anubis), duiker (Cephalophus spp.), and crocodile (Crocodylus niloticus) distribution in Bomfobiri Wildlife Sanctuary (BWS). Secondary data (camp reports 2017–2019) showed flagship species distribution across four vegetation types in 14 sites. Field observations were used to reconstruct camp report information using GPS coordinates to show animal distribution. Environmental factors were assessed based on the scope and severity of their threats to the species. PAST ver.3.06 was used to analyse animal and vegetation data. A total of 995 individual animals were recorded. Riverine forest (n = 325) had the highest, followed by semi‐deciduous (n = 316), and woodland Savanna (n = 192). Bushfire was the major predictive factor on animal distribution, followed by grazing pressure, farming activities, elevation, and erosion. These findings imply that an increased scale of disturbances reduces the chance of sighting flagship animals. A higher concentration of these species in riverine and semi‐deciduous forests calls for increased patrols as a conservation measure. Constructing viewing platforms and hiking trails in areas of higher animal activity would improve ecotourism development.

Effectiveness of buccal dental‐microwear texture in African Cercopithecoidea dietary discrimination

AbstractObjectivesThis study compares ISO (ISO/FDIS 25178) roughness parameters, calculated from three‐dimensional (3D) molar buccal microtexture surfaces, among African Cercopithecoidea primates with different diets.Materials and MethodsWe examined 98 lower second molars from seven African Cercopithecoidea species with diverse dietary regimes and habitat exploitation. Buccal dental surfaces were analyzed using a Sensofar Plu Neox laser scanning confocal microscope. Thirty‐eight, areal surface texture parameters were extracted (Mountain 7® software). Uni‐ and multivariate statistics were used to obtain diet‐related patterns of buccal‐microwear textures and feeding ecology to differentiate between species.ResultsBuccal‐dental 3D texture parameters discriminate between Cercopithecoidea diets. Analysis of variance (ANOVA) revealed significant variation in microwear texture between forest‐adapted Mandrillus sphinx, which showed coarse flat features, and grassland forager Theropithecus gelada, whose buccal surfaces were characterized by a high density of thin features. Buccal‐microwear textures of folivorous species (Colobus polykomos) were related to a lower density of thicker surface indentations in comparison to Papio anubis and Cercocebus atys which are adapted to the consumption of tough and hard foods. The limited interspecific variation in the buccal‐microwear textures of savanna dwellers (Chlorocebus pygerythrus and Chlorocebus aethiops) probably reflects similarities in their foraging diets.DiscussionSignificant variations between‐species demonstrate that 3D microwear ISO roughness parameters applied to buccal enamel surfaces can distinguish between the diets of Cercopithecoidea.

Mathematical modelling Treponema infection in free-ranging Olive baboons (Papio anubis) in Tanzania

Yaws is a chronic infection caused by the bacterium Treponema pallidum susp. pertenue (TPE) that was thought to be an exclusive human pathogen but was recently found and confirmed in nonhuman primates. In this paper, we develop the first compartmental ODE model for TPE infection with treatment of wild olive baboons. We solve for disease-free and endemic equilibria and give conditions on local and global stability of the disease-free equilibrium. We calibrate the model based on the data from Lake Manyara National Park in Tanzania. We use the model to help the park managers devise an effective strategy for treatment. We show that an increasing treatment rate yields a decrease in disease prevalence. This indicates that TPE can be eliminated through intense management in closed population. Specifically, we show that if the whole population is treated at least once every 5-6 years, a disease-free equilibrium can be reached. Furthermore, we demonstrate that to see a substantial decrease of TPE infection to near-elimination levels within 15 years, the whole population needs to be treated every 2-3 years.