Antral Pouches Research Articles

Effects of antral acidification and atropine on histamine-induced gastric secretion in dogs

To determine whether acid in the gastric antrum causes inhibition of HCl secretion in the fundus of the stomach, five dogs were prepared with antral and fundic pouches. In one animal these pouches had intact vagal innervation. In each experiment a small dose of histamine was administered at a constant rate for 5–6 hours. After the rate of HCl output from the fundic pouch leveled off, the antral pouch was perfused with acid for 3 hours. During this period the rate of HCl output sometimes fell below preperfusion level, but similar results were obtained without antral perfusion. The findings in 30 tests and 30 controls failed to suggest that antral acidification influenced the fundic secretion. In a parallel study, 2 mg of atropine produced marked inhibition of secretion, proving that true inhibitory effects were demonstrable with the methods employed. These findings raise doubt that the acidified antrum produces an antisecretory hormone or that it can inhibit fundic secretion via a vagal reflex.

Inhibitory effects of hydrochloric acid in antrum and duodenum on gastric secretory responses to test meal in Pavlov and Heidenhain pouch dogs.

AbstractInstillation of hydrochloric acid into the excluded duodenum inhibits the gastric secretion stimulated by test meal in both Pavlov and Heidenhain pouch dogs. This is in accordance with the assumption by several authors that a secretion‐inhibiting mechanism is activated by an acid milieu in the duodenum. The results also show that this mechanism operates independent of the vagal nerve supply to the gastric mucosa. Perfusion of an isolated antral pouch with hydrochloric acid had lesser and irregularly occurring inhibitory effects on the secretory responses in Pavlov pouch dogs.

Motility studies of isolated antral pouches before and after vagus denervation

The motility responses of vagus innervated and denervated antral pouches to electrical stimulation of the vagus nerves and to insulin hypoglycemia were determined. Electrical stimulation appears to be a reliable method of demonstrating the presence or absence of vagus nerve supply to the antrum both in acute studies and in preparations of several months' duration. The motility response of the antral pouch to insulin hypoglycemia was found to be a less reliable method of determining the presence or absence of vagal innervation largely because spontaneous hypermotility may occur and there is more room for difference of opinion in interpretation of the results obtained. The administration of glucose after an appropriate time interval, however, added significantly to the reliability of the test. By the methods employed the antral branches of the vagus nerves were found to be the only sources of vagus innervation of the antrum. No evidence was obtained to suggest effective parasympathetic innervation of the antrum via a pyloric nerve, via the greater curvature mesenteric attachment or via an intramural gastric pathway. Submitted on July 7, 1958

Inhibition of vagally stimulated gastric acid by the pyloric antrum.

It has been previously demonstrated that gastric acid production of antral and intestinal origin is inhibited by acidification of the antrum. In this experiment a vagally innervated gastric pouch (Hollander) and an excluded antral pouch were constructed in four animals, two of the antral pouches being vagally innervated and two denervated. The gastric pouches were stimulated to secrete in response to insulin hypoglycemia and the effect of acidification of the antrum tested. It was found that gastric secretion was reduced by acidification whether the antrum was denervated or not, the difference between the two being insignificant. It was concluded that the gastric acid produced in response to vagal stimulation is reduced by acidification of the antrum and that denervation of the antrum did not influence this result.

Heidenhain pouch secretory response to transplantation of the innervated and denervated antral pouch to the transverse colon.

Jones, Thomas W. M.D.; Stevenson, John K. M.D.; Jesseph, John E. M.D.; Nyhus, Lloyd M. M.D.; Habkins, Henry N. M.D. Author Information

Antral inhibition of gastric secretion.

SummaryA method has been devised for making a Heidenhain pouch and 2 separate, marsupialized, antral pouches in the dog. Studies performed on 4 dogs prepared in this way indicate that reduction of pH within one antral pouch will inhibit production of HCl in the Heidenhain pouch when the latter is under stimulation by perfusion of alcohol in the second antral pouch. It is assumed that gastric inhibition produced in this manner demonstrates release of an inhibitory hormone by the antrum; however, this awaits further study for clarification.