Booponuosis is a chronic disease of antler deer that affects growing antlers, causing significant economic damage to farms. Maral antlers are the main product of antler deer breeding. The purpose of the study is to analyze new effective medications for prevention and treatment of booponuosis of marals. The work was carried out on a breeding farm of the Altai-Sayan breed. This breed is distinguished by greater antler productivity than outbred antler deer, on average by 24%. Taking into account the peculiarities of keeping of semi-wild animals and products obtained from marals (antlers), treatment with medications was carried out in parts, in small groups of 10-12 animals during the period of antler cutting company. In total, 380 deer stags and first-horns participated in the experiment, they were divided into two equal groups. Diazinon-S (0.025% solution) was used in the first group, as for the second group, 0.02% Butox-50 solution was used. In total, both groups had 10 treatments with an interval of 3 days between them. As a result of the experiment with application of Diazinon-S, it was noted that larvae infestation was 18% with invasion extensity (in 34 animals) starting from the third treatment, and invasion intensity was from 5 to 8 larvae, which gradually increased, reaching with invasion extensity - 46% (87 deer) and with invasion intensity - 15-22 larvae by sixth treatment. As for the second group, no damage by antler fly larvae was observed throughout the experiment; the effectiveness of Butox-50 was 100%. To prevent further spread of boooponuosis in the first group and preserve the quality of products, the medication was changed to Butox-50 starting from the 6th washing (21 days), which allowed to eliminate boooponuosis in the group completely and prevent it until the end of the antler cutting company. It indicates high efficiency of Butox-50 against booponuosis causative agent of marals.