This study assessed the effects of anti-vibration gloves on vibration-induced disorders and identified any adverse effects on the participants. The article also highlights the difficulties of conducting research in an occupational environment.Ten missile assemblers (range 22–56 years of age) wore anti-vibration gloves for a 3-week trial. Each worker underwent an initial evaluation and a subsequent evaluation after the trial. The company was asked to measure changes in direct and indirect costs.The data were analyzed using paired t-tests and cross-tabulations. Although the statistical results were not significant, no significant adverse effects on symptoms of vibration-induced disorders were observed. The assemblers reported decreased discomfort, increased torque generation, and improved absorption of impact, heat, and vibration without interference with dexterity.Research in an occupational environment is complicated by incomplete records and limited controls with respect to duration, compliance, and subject morbidity. Sound research requires cooperation of employer and employees, meticulous record-keeping, complete medical histories, and minimal changes in worker production and absenteeism. Cost benefit analysis should include expenses for medical care, workers’ compensation, and insurance.