In this short paper, we argue that the chiral central charge c− of a (2+1)d topological ordered state is sometimes strongly constrained by 't Hooft anomaly of antiunitary global symmetry. For example, if a (2+1)d fermionic topological quantum field theory (TQFT) has a time-reversal anomaly with T2=(−1)F labeled as ν∈Z16, the TQFT must have c−=1/4 mod 1/2 for odd ν, while c−=0 mod 1/2 for even ν. This generalizes the fact that the bosonic TQFT with T anomaly in a particular class must carry c−=4 mod 8 to fermionic cases. We also study such a constraint for fermionic TQFT with U(1)×CT symmetry, which is regarded as a gapped surface of the topological superconductor in class AIII.Received 5 January 2021Revised 16 March 2021Accepted 12 April 2021DOI:https://doi.org/10.1103/PhysRevResearch.3.023107Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.Published by the American Physical SocietyPhysics Subject Headings (PhySH)Research AreasSymmetry protected topological statesTopological field theoriesTopological superconductorsCondensed Matter, Materials & Applied Physics