PurposeTo report the use of eye wall resection in the management of tuberculous granuloma. DesignInterventional case report. MethodsIn a 26-year-old man with biopsy-proven tuberculous granuloma of the left eye, total eye wall resection and donor scleral grafting was performed for management of tuberculous granuloma involving the sclera, part of the cornea, the iris, the chamber angle, and the ciliary body. Adjuvant therapy included oral antitubercular medication. ResultsThe treatment of the infection was successful. The scleral graft healed well, and the crystalline lens was preserved. ConclusionsTotal eye wall resection, a technique described in the management of uveal tumors, can be adopted to manage selected cases of tuberculous granuloma of the eye.