Experiments are described that have been designed to measure separately annihilation and reaction cross sections for antiprotons of approximately 450 Mev on oxygen, copper, silver, and lead. A new and more luminous spectrograph has been built for this experiment. The antiproton cross sections are compared with total proton cross sections, and are found to be larger by a factor varying from 1.74 for oxygen to 1.39 for silver. Calculations based on the optical model give a reasonable connection between these cross sections and the $\overline{p}\ensuremath{-}p$ and $\overline{p}\ensuremath{-}n$ cross sections. Finally, the information available on antiproton production cross sections is collected. There are indications that a free nucleon is several times as effective as a bound one for producing antiprotons.
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