Article1 January 1936EXPERIMENTAL THROMBOPENIC PURPURA; CYTOLOGICAL AND PHYSICAL CHANGES IN THE BLOODLEANDRO M. TOCANTINSLEANDRO M. TOCANTINSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-7-838 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen a moderate dose of antiplatelet serum is given to a dog, the animal develops an attack of purpura hemorrhagica, identical in most respects with the human type, and recovers spontaneously. The changes that accompany such a disease in the dog have not as yet been systematically investigated. The observations here presented are the result of a study of some of these changes in a group of 63 dogs in each one of which purpura was produced one or more times.EXPERIMENTAL METHODSCytology. Various methods of counting platelets1, 2, 3were tried and the direct method was finally selected....