Globally, transgender people engaged in sex work experience disproportionately high risks of victimization. While qualitative studies on the perspectives of transgender people engaged in sex work can shed light on their intersecting experiences, a qualitative synthesis could offer a systematic understanding and inform anti-oppressive practices and policies. This review explores the experience of stigma, violence, victimization, and associated coping strategies among transgender people engaged in sex work. We conducted a literature search in November 2023 on MEDLINE, Social Work Abstracts, and CINAHL PLUS from EBSCOhost, APA PsycInfo, ASSIA, and Sociological Abstracts from ProQuest and SCOPUS (PROSPERO ID: CRD42023478844). From 1,085 studies retrieved, 64 were included in this review. Thematic synthesis identified seven themes: (a) individual struggle, (b) interpersonal violence, (c) community transphobia and exclusion, (d) systemic oppression, (e) individual coping strategies, (f) community resources, and (g) organizational support as coping resources. This review contributes to the discussion around the health vulnerabilities of transgender people engaged in sex work that inherently result from intersecting victimization in a larger global context, including trafficking, urban planning, migration, and COVID-19. Identification of the coping strategies of transgender people engaged in sex work also highlights their resilience and sites of empowerment. Policymakers and professionals should be mindful of the intersectional identities of transgender people engaged in sex work and initiate peer- and community-led interventions to support them in building intersectional solidarity and resisting victimization.