The article discusses the content, history of development and theoretical foundations of the regional strategy of digitalization of the economy of the United Nations Economic Commission for Latin America and the Caribbean (ECLA), the impact of ECLA on the development of digitalization processes in the region. The acceleration of digitalization processes in the world and in the Latin American region is noted as the leading trend of economic and social life during the coronavirus pandemic and on the way out of the associated crisis. The connection of the ECLA digitalization strategy with the comprehensive regional development strategy put forward in 2010, which is based on the neo-structuralist ideas of the need to transform the production structure of the countries of the region, the elimination of poverty, deep social inequality, as well as with the theory of sustainable development, is traced. The main priorities of the digitalization strategy are identified: ensuring universal access to broadband high-speed Internet, introducing digital technologies into production, helping to digitalize small and medium-sized enterprises, creating a common regional digital market, tax and antimonopoly regulation of the activities of foreign technology companies, security and protection of personal data. The author highly appreciates the role of ECLA in the development of digitalization processes in the region, but expresses doubt about the feasibility of the task of accelerated digital transformation of its economy in the foreseeable future due to barriers associated with the traditional model of development of Latin American countries.