Antimicrobial Resistance Of Uropathogens Research Articles

Impact of Changing Patterns of Antimicrobial Resistance in Uropathogens: Emerging Treatment and Strategies.

Urinary tract infection (UTI) is common, especially in women, and the microbiology of UTI is predictable. Over the past decade, numerous reports have documented increasing resistance among uropathogens to first-line agents for the treatment of UTI, especially trimethoprim/sulfamethoxazole (TMP/SMX). It is recommended that TMP/SMX should not be administered as empiric therapy for UTI in communities where resistance rates exceed 20%. However, reliable data regarding the true prevalence of resistance in a community are often lacking. Preliminary work has suggested that recent antimicrobial use is an important risk factor for infection with a TMP/SMX-resistant isolate. A better understanding of the epidemiology of resistance is needed to aid therapeutic decisions and devise interventions to reduce or slow emerging resistance.

Relationship between demographic characteristics and community-acquired urinary tract infection

To investigate the effect of age, sex and marital status on the etiology of community-acquired urinary tract infection and the antimicrobial resistance of uropathogens, urine specimens collected from 270 outpatients were analysed and 121 significant monomicrobial cultures obtained. The microorganisms were identified and their susceptibility to 14 selected antimicrobial agents was determined. These results were then related to the age, sex and marital status of the patients. This study concludes that understanding the effect of the different factors on community-acquired urinary tract infections and their antimicrobial resistance will aid the proper management of this disease.