Antihyperlipidemic Effects Research Articles

Lactiplantibacillus plantarum TCCC11824 exerts hypolipidemic and anti-obesity effects through regulation of NF-κB-HMGCR pathway and gut microbiota in mice and clinical patients

A strong association exists between the high-fat diet (HFD) and the incidence of obesity, hyperlipidemia and cardiovascular disease, affecting an increasing number of individuals. More and more research has shown that probiotics and gut microbiota play important roles in dietary absorption, metabolism and host healthy. This study aims to evaluate the therapeutic effects and the underlying mechanisms of Lactiplantibacillus plantarum TCCC11824 (CGMCC 8198) on hyperlipidemia and obesity in mice and clinical. Fristly, there was a dose-dependent improvement in HFD-induced hyperlipidemia and obesity in mice which had been treated with L. plantarum TCCC11824 for 5 weeks thus restoring the balance of the gut microbiota. Furthermore, it showed that cell lysate of L. plantarum TCCC11824 could directly exhibit protective effects on the hepatocytes steatosis induced by oleic acid, and regulate the expression of HMGCR by inhibiting NF-κB pathway. Importantly, L.plantarum TCCC11824 ameliorated the expression of indicators of hyperlipidemia and inhibited the synthesis of SCFAs (short-chain fatty acids), as shown by blood and fecal tests in hyperlipidemic patients. In summary, L. plantarum TCCC11824 exerts anti-hyperlipidemic and anti-obesity effects through the regulation of HMGCR via NF-κB and modulating gut microbiota, indicating its potential as a dietary supplement for the treatment of hyperlipidemia and obesity.

Wheat β-glucan reduces obesity and hyperlipidemia in mice with high-fat and high-salt diet by regulating intestinal flora.

Unbalanced diets, characterized by high fat or high salt content, are contributing to the obesity epidemic. Wheat bran, recognized as a promising by-product, has the potential to regulate metabolic disorders (MD) associated with obesity. Beta-glucan (BG) has multiple biological activities, but the effect of BG in wheat bran on MD remains unclear. Therefore, this study aimed to investigate the effects of wheat BG (WBG) on dyslipidemia and gut microbiota dysregulation in high fat (HF) or high fat-high salt (HFHS) fed mice. The results demonstrated that WBG significantly reduced the weight gain of mice fed with HF and HFHS diets (from 9.74g to 2.43g and from 6.74g to 2.48g, respectively). Additionally, WBG led to significant reductions in TG (26.26% in HFG and 33.78% in HFHSG) and TC (34.69% in HFG) levels. The liver and adipocyte damage were also reduced after dietary supplementation with WBG. Moreover, WBG significantly reduced Firmicutes/Bacteroidetes ratio (9.52 at HF, 0.62 at HFG, 17.38 at HFHS and 0.61 at HFHSG). Concurrently, there was a reduction in acetic acid levels observed at rates of 26.11% for HF and 32.18% for HFHS. Additionally, WBG reduced the abundance of Coriobacteriaceae UCG-002, Romboutsia, Faecalibaculum, and Enterorhabdus that positively associated with obesity. These changes in gut microbiota may explain the anti-obesity and anti-hyperlipidemia effects of WBG. In conclusion, our findings suggest that WBG is a promising dietary supplement. Our research can provide new insights into the development of foods rich in dietary fiber.

Study of the antihyperlipidemic effect of Ammodaucus leucotrichus essential oil in rats

Study of the antihyperlipidemic effect of Ammodaucus leucotrichus essential oil in rats

The multifaceted benefits of Morus nigra L.: a pharmacological powerhouse

Abstract The black mulberry (Morus nigra L.), a member of the Moraceae family, is a resilient plant known for thriving in diverse climates. It is valued for its rich composition of both primary and secondary metabolites, which contribute to a wide range of health benefits. Among the most significant of these are anthocyanins, which are responsible for the plant's antioxidant, anti-inflammatory, and antibacterial properties. Traditionally, Morus nigra has been widely used in Chinese and Indian medicine to treat a variety of conditions, including diabetes, hypertension, and neurodegenerative diseases. Recent scientific studies have supported these traditional uses, highlighting the plant's potential in modern medicine. Specifically, Morus nigra has demonstrated positive effects on cardiovascular health, blood sugar regulation, and tissue protection. The fruit of the mulberry is rich in primary metabolites such as carbohydrates, proteins, and essential fatty acids, enhancing its nutritional value. Secondary metabolites, including flavonoids and phenolic compounds, are particularly important for their role in reducing oxidative stress and inflammation. Additionally, Morus nigra has shown promising antidiabetic and antihyperlipidemic effects, influencing metabolic pathways related to insulin resistance and lipid regulation. Despite its many health benefits, caution is needed when using Morus nigra in supplement form, particularly in high doses. While the fruit is generally safe for consumption, studies on leaf extracts have revealed potential toxicity at elevated doses, emphasizing the need for careful dosage. Further research is essential to determine optimal intake levels and fully explore the plant's pharmacological potential.

Anti-hyperlipidemic and antioxidant effects of halophilic Archaea carotenoids extracts on high-fat fed mice

Anti-hyperlipidemic and antioxidant effects of halophilic Archaea carotenoids extracts on high-fat fed mice

The Importance of Edible Medicinal Mushrooms and Their Potential Use as Therapeutic Agents Against Insulin Resistance.

In addition to conventional treatments, there is growing interest in preventive and complementary therapies. Proper nutrition can prevent the manifestation of several chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer, and can attenuate the severity of these diseases. Edible mushrooms have been used as nutrition and medicine for thousands of years. The spectrum and quantity of their medicinal compounds made them a widely investigated target both in basic research and clinical trials. The most abundant and medically important components are polysaccharides, terpenoids, phenols, and heterocyclic amines, but bioactive proteins, vitamins, including vitamin D, polyunsaturated fatty acids, and essential minerals are also important ingredients with noteworthy health benefits. Mushroom extracts have anti-diabetic, anti-hyperlipidemic, anti-inflammatory, antioxidant, cardioprotective, anti-osteoporotic, and anti-tumor effects and are well tolerated, even by cancer patients. In our previous review we detailed the molecular aspects of the development of type 2 diabetes, discussing the role of physical activity and diet, but we did not detail the role of medicinal mushrooms as part of nutrition. In this review, we aimed to summarize the most important medical mushrooms, along with their natural habitats, growing conditions, and components, that are presumably sufficient for the prevention and treatment of insulin resistance.

Potential antihyperlipidemic effects of myrcenol and curzerene in high-fat fed rats

The study evaluated the anti-hyperlipidemic effects of myrcenol and curzerene on a high fat diet induced hyperlipidemia rat model. Thirty male albino rats were fed on a high-fat diet for four months. The HFD-induced hyperperlipidemia rats were treated with rosuvastatin (10 mg/kg), curzerene (130 mg/kg) and myrcenol (100 mg/kg) for four weeks. Blood samples were collected for further analysis. Aorta and heart were harvested for histopathological evaluation. Hepatic lipase and HMG-CoA reductase were determined by ELISA. FST and Y-maze tests were performed to assess the stress level in hyperlipidemia rats. The phytochemical compounds (Curzerene and Myrcenol) and the standard drug (Rosuvastatin) resulted in decreased body weight as well as reduced levels of LDL, TG, TC, AST and ALT as compared to the diseased group. Additionally, the treated groups displayed improved HDL levels and less depressed behavior. The ELISA results revealed that the Curzerene and myrcenol had significantly increased the protein concentration of hepatic lipase than the diseased group whereas both compounds significantly lowered the HMG-CoA reductase concentrations compared to the diseased group. The findings suggested that myrcenol and curzerene had the potential to be therapeutic agents for managing hyperlipidemia and reducing the risk of heart-related conditions associated with high lipid levels.

Characterization and interactions between piperine and ezetimibe in their Anti-hyperlipidemic efficacy using Biopharmaceutics and Pharmacokinetics

BackgroundPiperine, a secondary metabolite, affects the antihyperlipidemic effect of Ezetimibe (EZ). Hyperlipidemia is one of the independent risk factors for cardiovascular disorders such as atherosclerosis. Antihyperlipidemic drugs are essential for reducing cardiovascular events and patient mortality. Our study aimed to improve the solubility of EZ, a lipid-lowering drug that belongs to BCS II and has low solubility. Piperine, a bioenhancer, can increase the bioavailability of other pharmaceuticals without modifying their fundamental characteristics or enhancing their efficacy. The objective of this study was to increase the bioavailability of EZ while also improving its potency and reducing its toxicity by using piperine as a bioenhancer. Therefore, rats were given piperine combined with EZ, and their antihyperlipidemic activity was assessed while fed a high-fat diet.MethodThe in vivo antihyperlipidemic effect of EZ with piperine was assessed at doses of 10 and 5–20 mg/kg b.w. The evaluation was conducted using propylthiouracil-induced and triton X-100-induced hyperlipidemia in rats. Give 400 mg/kg body weight of propylthiouracil along with piperine. Serum levels of total cholesterol (TC) (p < 0.01), triglycerides (TG) (p < 0.01), low-density lipoprotein (LDL) (p < 0.01), and very low-density lipoprotein (VLDL) (p < 0.01) all went up significantly. Additionally, it led to the induction of high-density lipoprotein (HDL) (p < 0.01). Administration of Triton X-100 via intraperitoneal injection at a single dose resulted in an elevation of lipid levels.ResultsLower levels of high-density lipoprotein (LDL), total cholesterol (TC), triglycerides (TG), and very low-density lipoprotein (VLDL) were significantly reduced by EZ at 10 mg/kg b.w. and piperine at 20 mg/kg b.w., respectively (p < 0.01 and p < 0.05). Liver histology studies provided further evidence supporting the present findings. Areas of concentrated periportal lymphocytes and hepatocytes formed a cord pattern in rats with hyperlipidaemia. It seemed like the hepatocytes, periportal area, and centrilobular part of the liver were all normal in the group who had the treatment. An analysis of the EZ plasma drug concentration with time was carried out in a research. The medication’s most effective concentration (Cmax) was determined to be within 4 h after delivery, and The quantified concentration of the active medication was detectable in the bloodstream for 24 h.ConclusionIn combination with piperine, EZ has demonstrated significant antioxidant and antihyperlipidemic effects. This indicates that EZ could be further utilised for treating hyperlipidemia and atherosclerosis due to its potential to boost the bioavailability and oral absorption of the drug.

An Overview of the Current Scientific Evidence on the Biological Properties of Abelmoschus esculentus (L.) Moench (Okra).

Abelmoschus esculentus (L.) Moench, commonly known as okra or lady's finger, is an annual flowering plant belonging to the Malvaceae family. Okra is a native plant in Africa as well as a traditional medicine in Africa and India for treating different diseases and conditions. Today, okra is widely consumed as a vegetable and is increasingly recognized as a superfood due to its rich nutritional profile and potential pharmacological benefits. Research indicates that okra exhibits a range of biological activities, including antidiabetic, antihyperlipidemic, antifatigue, vasoprotective, hepatoprotective, antitumor, anti-inflammatory, and antimicrobial effects. Despite its promising therapeutic potential, research on the active compounds in okra and evaluating efficacy in clinical settings remains limited. This review aims to consolidate existing scientific knowledge on the biological and pharmacological properties of okra, thereby encouraging further investigation into its health benefits. Ultimately, this could pave the way for the development of functional foods or health supplements that leverage okra as a key ingredient to prevent chronic diseases and enhance overall health outcomes.

Paederia Foetida Linn (Rubiaceae): Chemical Diversity, Phytopharmacological Potential, Quantitative Analysis and Clinical Approaches.

The discovery of novel counteractive pharmaceuticals, which have recently generated much interest, has played a significant role in the development of drugs derived from herbal medicines or botanical sources. Paederia foetida (P. foetida) is one such example of a role in both traditional and traditional medicine. Owing to its popularity in folk medicine, it has been the subject of intense pharmacological and chemical studies for the last 30 years. They are locally known as "Gandhavadulia" or "GandhaPrasarini" (English name "skunkvine") and belong to the family Rubiaceae. This plant has a broad range of applications in the treatment of several illnesses, including anti-inflammatory, antinociceptive, antitussive, thrombolytic, antidiabetic, antihyperlipidaemic, antioxidant, nephroprotective, anti-inflammatory, hepatoprotective, anthelmintic, and antidiarrheal effects. Additionally, it contains a variety of phytochemicals, such as asperuloside, paederosidic acid, sitosterols, campesterol, lignans, alkaloids, volatile oils, iridoids, methylindooxy substances, stigmasterol, tannins, triterpenoids, ellagic acid, ursolic acid, epifriedelinol, and phenolic compounds. Recently, mounting data on numerous active ingredients have indicated that they may be beneficial for spermatogenesis, wound healing, inflammatory illnesses, and cancer. This review describes the phytochemistry and mechanisms of action of these pharmacological effects and provides insights into potential pharmacological targets. These results highlight the need for additional studies on this medicinal plant and the investigation of new counteractive medications to determine their mode of action before use in healthcare.

Current advances on the phytochemistry, pharmacology, quality control and applications of Anoectochilus roxburghii.

Anoectochilus roxburghii (Wall.) Lindl. (AR) is a perennial herb that has long been used as medicinal and edible plant. In Traditional Chinese Medicine (TCM), AR is utilized to treat various diseases including hyperuricemia, type 2 diabetes mellitus, cancers and inflammatory diseases. Recent advances in the discovery and isolation of bio-active compounds have unveils the main medicinal ingredients, such as quercetin, kinsenoside and rhamnazin. Pharmacological studies further demonstrated its activities, containing anti-inflammation, anti-oxidation, and antihyperlipidemia effects. The processed AR products have various commercial applications in functional foods and cosmetics. AR has been used to prepare soup, drinkbeverage, jelly, face masks, soap, etc. However, despite the abundant medicinal value, it hasn't been included in the 2020 Chinese Pharmacopoeia up to now. There is also no consistent evaluation standard across provinces. This seriously affects the safety and the efficacy of TCM prescriptions, not to mention the development question. This review summarizes recent research on AR in phytochemistry, pharmacology, quality control and applications, raises the corresponding solutions to provide references and potential directions for further studies.

Therapeutic Potential of Quercus İthaburensis Subsp. Macrolepis Fruit Extract in Stz-nicotinamide-induced Type 2 Diabetic Rats

In this study; the effect of Quercus ithaburensis subsp. macrolepis fruit extract (QIFE) on blood glucose and oxidant-antioxidant systems in streptozotocin (STZ)-nicotinamide-induced type 2 diabetic rats was investigated. Type 2 diabetes was induced in rats by intraperitoneal injection of STZ (65mg/kg)-Nicotinamide (45 mg/kg). Rats were given 535mg/kg QIFE fruit extract in their drinking water for 21 days. Rats were divided into four groups; Control (C), Control+QIFE (C+QIFE), Diabetes (D), and Diabetes+QIFE (D+QIFE). Plasma and tissue malondialdehyde (MDA) levels were measured by spectrophotometry. Whole blood glutathione peroxidase (GSH-Px), serum superoxide dismutase (SOD) enzyme levels, serum paraoxonase (PON), and arylesterase (ARE) enzyme activities were determined using commercial kits. Serum insulin levels and blood glucose were evaluated using a Rat ELISA Kit and glucometer, respectively. Also, the autoanalyzer was used to assess the lipid profile. While blood sugar and serum total cholesterol (TC) levels showed a statistically significant decrease in the C+ QIFE and D+ QIFE groups (C and D groups, respectively), serum insulin levels showed a statistically significant increase in the D+QIFE group compared to the D group. In the D+QIFE group, a statistically significant increase was observed in PON and ARE enzyme activities compared to the D group, but in the C+QFE group, a significant increase was found in whole blood GSH-Px and serum SOD levels compared to the C group. A statistically significant decrease was detected in plasma, heart, muscle, and liver tissue MDA levels in the D+QIFE group compared to the C group. As a result, it was concluded that Q. ithaburensis fruit extract has anti-hyperglycemic, anti-hyperlipidemic effects, strengthens the antioxidant system, and is a good phytotherapeutic agent that prevents/improves metabolic processes and related complications related to diabetes mellitus.

Date palm (Phoenix dactylifera) bioactive constituents and their applications as natural multifunctional ingredients in health-promoting foods and nutraceuticals: A comprehensive review.

Foods that support human health and longevity are becoming increasingly relevant as substitutes for or adjuncts to pharmacological drugs, either through direct consumption or incorporation into designer foods fortified with health-promoting ingredients. Date palm (Phoenix dactylifera L.) fruits, seeds, and pollen are a cornerstone of diverse food and medicine traditions. Their reported metabolic activities include anti-inflammatory, antioxidant, antihypertensive, antihyperlipidemic, antidiabetic, antitumor, antianemia, hepatoprotective, antibacterial, and antiviral effects. Beneficial effects on gut health and vascular health, as well as effectiveness in alleviating certain dysfunctions of the reproductive system, have also been noted. The genomic diversity of this versatile tree and the diverse agroecological conditions in which it grows lead to appreciable variations in the occurrence of protective nutrients and other high-value bioactive phytochemicals, including flavonoid and non-flavonoid phenolics, carotenoids, phytosterols, and oxylipins, whose potential remains underutilized in the food sector. As food ingredients, date fruits and their co-products can improve the sensory, nutritional, and nutraceutical qualities of a broad range of dietary items. Their high nutritional density can assist with the design of novel or improved products that meet the demand for healthier foods. This review summarizes the current state of evidence on the potentialities of date palm fruits and co-products in functional food development, focusing on the nutrients and extra-nutritional compounds of interest, their biofunctional activities, and factors that influence their abundance and bioactivity. Proofs of concept across food and beverage categories, new developments, and clinical evidence are discussed, followed by recommendations for addressing research gaps.

Anti-hyperlipidemic Effect of Camellia hakodae Ninh Extract in an In Vivo Rat Model

Anti-hyperlipidemic Effect of Camellia hakodae Ninh Extract in an In Vivo Rat Model

Formulation and Evaluation of Anti-Hyperlipidemic Tablet

Hyperlipidemia is one of the leading causes of mortality in developed as well as in developing countries like India. It attributes to the high risk of coronary heart disease and atherosclerosis which is referred as a silent killer. Herbal treatment for hyperlipidemia is inexpensive, readily available locally, and has no negative side effects. Medicinal plants are the "backbone" of traditional medicine so considered as good source of life for all people due to its wealthy therapeutic properties and being 100% natural. Several drugs in Siddha have been found to be beneficial in lowering lipid levels without any major adverse effects. Numerous plants like arjuna, ashwagandha, garlic, guggul, etc. have been reported to have lipid-lowering effects. The goal of the review paper is to examine the potential anti-hyperlipidemic effects of herbal plants using a variety of models. The anti-hyperlipidemic activity of the most well-known medicinal herbs is the focus of this review.

Anti-hyperlipidemic effect of Purslane on high fat-diet-induced hyperlipidemic rats

Anti-hyperlipidemic effect of Purslane on high fat-diet-induced hyperlipidemic rats

Antidiabetic, Antihyperlipidemic and Protective Effect of Cupressus sempervirens L. Leaves Extract in Streptozotocin Induced Diabetic Rats

Antidiabetic, Antihyperlipidemic and Protective Effect of Cupressus sempervirens L. Leaves Extract in Streptozotocin Induced Diabetic Rats

The Bromodomain and Extraterminal Protein Inhibitor Apabetalone Ameliorates Kidney Injury in Diabetes by Regulating Cholesterol Accumulation and Modulating the Gut Microbiota

IntroductionAn FDA-approved new bromodomain (BRD) and extra-terminal (BET) bromine domain antagonist called apabetalone, which targets BRD4, has been shown to raise preβ1-HDL(Prebeta-1 High-Density Lipoprotein) particles, enhance apolipoprotein A-I in both humans and animals, and restore angiogenesis in experimental diabetes. Its action is not, however, fully known mechanistically. The objective of our research was to investigate the impact of apabetalone on renal damage linked to diabetic kidney disease (DKD). MethodsThis research employed both pharmacological and genetic methods to examine the impact of apabetalone on db/db (BKS. Cg-leprdb/leprdb) mice and human tubular epithelial cells (HK-2). ResultsHere, significant reductions in blood creatinine, urea nitrogen and UACR(urinary albumin/creatinine ratio) levels, serum triglycerides (TG) and serum total cholesterol (TC), as well as ectopic lipid droplet formation in renal tissue, were seen in the db/db mice following apabetalone therapy. Analysis of the gut microbiota revealed changes in its composition. Significantly, the proportion of Firmicutes to Bacteroidetes decreased as well as Deferribacterota, indicating a positive influence on lipid metabolism. Untargeted metabolomic analysis also indicated that the ABC transporter signaling pathway, implicated in cholesterol metabolism, was enriched. Moreover, peroxisome proliferator-activated receptor-gamma (PPARγ)/liver X receptor (LXR)/ABCA1(ATP-binding cassette transporters A1) protein and mRNA level as well as fibrosis-related marker proteins FN(Fibronectin) and Collagen I were all improved by apabetalone. ConclusionTherefore, we suggest that apabetalone showed significant anti-hyperlipidemic and anti-fibrotic effects, closely associated with alterations in the gut microbiota and cholesterol metabolism. The results of this investigation provide fresh perspectives on the processes that underlie apabetalone's effects in db/db mice.

Transcriptomic Analysis of the Protective Effect of Piperine on Orlistat Hepatotoxicity in Obese Male Wistar Rats.

Obesity is a risk factor for the development of noncommunicable diseases that impair the quality of life. Orlistat is one of the most widely used drugs in the management of obesity due to its accessibility and low cost. However, cases of hepatotoxicity have been reported due to the consumption of this drug. On the other hand, piperine is an alkaloid found in black pepper that has demonstrated antiobesity, antihyperlipidemic, antioxidant, prebiotic, and hepatoprotective effects. The aim of this study was to evaluate the protective effect of piperine on the toxicity of orlistat in liver tissue. Obese male rats were administered piperine (30 mg/kg), orlistat (60 mg/kg), and the orlistat-piperine combination (30 mg/kg + 60 mg/kg) daily for 6 weeks. It was observed that the orlistat-piperine treatment resulted in greater weight loss, decreased biochemical markers (lipid profile, liver enzymes, pancreatic lipase activity), and histopathological analysis showed decreased hepatic steatosis and reduction of duodenal inflammation. Transcriptomic analysis revealed that the administration of piperine with orlistat increased the expression of genes related to the beta-oxidation of fatty acids, carbohydrate metabolism, detoxification of xenobiotics, and response to oxidative stress. Therefore, the results suggest that the administration of orlistat-piperine activates signaling pathways that confer a hepatoprotective effect, reducing the toxic impact of this drug.

Evaluation of bioactive components of Alchornea cordifolia leaf extract and its in vitro antidiabetic and in vivo anti-hyperlipidemic properties in Wistar rats with hyperlipidemia induced by P407

BackgroundAlchornea cordifolia is a shrub or small tree common in tropical Africa as it serves as food and traditional medicine in many local communities. The current research was carried out to determine the nutritional, phytochemical, in vitro antioxidant as well as the in vivo anti-hyperlipidemic effects of the ethanolic extracts of A.cordifolia (EEAC) leaf on experimentally induced hyperlipidemia. MethodologyA total number of 30 rats comprising experimental and control animals were used in this study. Wistar rats with poloxamer-47 induced hyperlipidemia as well as control were randomly divided into five groups of six animals each viz. Normal control group (I), induced rats with 500 mg/kg of P-407 receiving distilled water only group (II) induced rats with 500 mg/kg dose of P-407 and treated with Atorvastatin (ATV) at 20mg/kg body weight/day (III). Induced rats with 500mg/kg dose of P-407 and treated with A.cordifolia leaves extract (AC) at 500mg/kg body weight/day (IV), induced rats with 500 mg/kg dose of P-407 and treated with A.cordifolia leaves extract (AC) at 1000 mg/kg body weight/day (V). The administration of all treatments was through oral gavage and the duration was 21 days. ResultsThe proximate, phytochemical, vitamins and minerals analysis showed that A. cordifolia leaf extract is rich in Carbohydrates, protein, crude fibre Vitamins A and B with a moderate amount of Vitamins B and C, sodium, calcium, and iron. The phytochemical analyses revealed that the leaf extract of A.cordifolia has a high amount of phenolics, flavonoids, and to a lesser extent phytosteroids, coumarins, alkaloids, terpenoids, and glycosides. in vitro antioxidant analysis showed A.cordifolia demonstrated dose-dependent percentages of Apx, ABTS and DPPH radical scavenging activities. The animal studies showed that A.cordifolia extract significantly reversed the complications exerted by poloxamer-407 on Wistar rats. Extract characterization by Liquid chromatography-mass spectrometry (LC-MS) identified cyanidin-3-galactoside-5-(6-p-coumarylglucoside) (RT=37,945), 2, 3-dihydroxystearic acid (RT=21,850) and 9, 12, 15-octadecatrienal (RT=18,200) as the three most abundant bioactive compounds that could be responsible for the bioactivity of the plant. ConclusionIn conclusion, the ACEE can be considered a promising alternative therapeutic option for the management of hyperlipidemia owing to its antihyperglycemic, hypoglycemic and antioxidant effects in hyperlipidemic rats.