Objective To summarize the clinical manifestation, diagnosis and treatment methods of ochronotic joint disease, thus to improve grassroots medical workers awareness of ochronotic arthritis. Methods The clinical data of 1 case of ochronotic arthritis in the Second Municipal Hospital of Weihai Affiliated to Qingdao University and literature data were analyzed. Results The male patient, 65 years old, because the right femoral neck fracture admitted to accidentally falls in patients with bilateral antihelix ear cartilage and local black pigmentation, resection of the femoral head cartilage surface, black, dark color round ligament, partial hip joint capsule was dark, multi segmental lumbar vertebral intervertebral space narrowing disc hardening, laboratory urine silver nitrate and ammonium hydroxide examination appear dark brown discoloration, confirmed the diagnosis of patients with ochronotic joint disease. Conclusion We should improve cognition of ochronotic joint disease, examination by medical history, clinical manifestations, laboratory and imaging, diagnosis of ochronotic arthritis, thus to reduce the rate of misdiagnosis. Key words: Joint diseases; Ochronosis; Case reports; Review literature as topic