Goats play an important role in the livelihood of the farmer but their frequent encounter with gastrointestinal nematodes causes retarded growth, mortality, and production losses. A cross-sectional descriptive study was conducted between August and November 2023 to determine the prevalence, level of infections, and its association with various risk factors. A total of 350 fecal samples of goats were collected per rectally using the purposive sampling method from the smallholder and commercial farm of Tilottama Municipality, Rupandehi, Nepal. The collected sample was subjected to floatation and the McMaster technique for qualitative and quantitative examination with saturated NaCl solution. Data was entered in MS Excel 2013 and analysis was performed in SPSS version 25. Out of 350 samples, 242 (69.14%) were found to be positive for gastrointestinal nematodes among which the Strongyle group (60%) including Haemonchus spp., Oesophagostomum spp., Trichostrongylus spp., Bunostomum spp.), Strongyloides sp. (38.57%), and Trichuris spp. (11.14%). The EPG of the total positive sample was 1352 (192.610). Statistically, there was a significant association among the smallholder vs commercial for prevalence rates (p = 0.000242) rates and EPG (p = 0.003). The statistical difference was also observed based on deworming status for the prevalence of nematodes and EPG count (p = 0.016). The practice of good housing, grazing and pasture management, feeding of supplements, and deworming at a regular interval must be maintained to promote growth, minimize mortality & production losses, and maximize the returns from animals.