Abstract: Heterocyclic compounds form a major class of compounds in chemistry. There has been considerable interest in the development of novel heterocyclic compounds with varied biological activities. Azoles are famous and widespread scaffold in the pharmaceutical industry due to their range of activities. Diazocarbonyl compounds have found numerous applications in many areas of chemistry. Among the most developed fields of diazo compounds. This approach represents a useful alternative to more conventional methods of the synthesis of azoles. The present review discussed the different characteristics of the azoles of interest, to recognize the differences in pharmacolog, safety, toxicity and potential drug interactions of these antifungal agents.