Anticipatory Phase Research Articles

Decomposing the effort paradox in reward processing: Time matters

Effort expenditure not only discounts reward value prospectively but also accrues reward value retrospectively. To decompose the effort paradox in reward processing, the current event-related potential study investigated the neural dynamics underlying effects of effort expenditure on subsequent reward processing. Participants exerted one of two levels of effort to obtain an opportunity of winning a high or low amount of monetary reward, and we focused on electrophysiological activity during the anticipatory and consummatory phases of reward processing. During the anticipatory phase, the stimulus-preceding negativity was enhanced when potential high rewards were anticipated, but this reward effect disappeared following high-effort expenditure. During the consummatory phase, feedback-related ERPs were increased for high relative to low rewards, and this reward effect was enlarged following effort expenditure during the early stage (200–300 ms) as indexed by the reward positivity but not the late stage (400–600 ms) as indexed by the P3. Our findings provide a strong support for the psychological contrast theory and indicate that time matters in decomposing the effort paradox for reward processing such that effort expenditure reduces reward sensitivity during the anticipatory phase but enhances reward sensitivity during the consummatory phase.

Individuals with stroke improve anticipatory postural adjustments after a single session of targeted exercises

Impairment of anticipatory postural adjustments (APAs) is an important source of postural instability in older adults and individuals with neurological disorders. The aim of the study was to investigate whether APAs could be improved in people with stroke as a result of targeted exercise involving their unaffected upper extremity. Nine individuals with stroke and five healthy control individuals participated in the laboratory tests before and after a single session of practice consisting of pushing a medicine ball attached to the ceiling and stopping the ball with their palm when it returns. The tests included self-initiated perturbations induced by fast, discrete shoulder flexion movements and external perturbations induced by a pendulum impact. Bilateral EMG activity of eight trunk and leg muscles was recorded and analyzed during the anticipatory phase of postural control. Significantly early APAs onsets (p < .05) were seen in trunk and leg muscles after a single session of practice as compared to pre-practice in both the groups and individuals with stroke improved their ability to generate APAs more than control group. While the improvement was more pronounced on the unaffected side of the body, enhanced APAs were recorded on the affected side as well. The observed practice-related earlier activations of muscles confirm a possibility of APA enhancement in individuals with stroke. The outcome provides a background for the development of balance rehabilitation protocols focused on improvement of anticipatory postural adjustments in individuals with neurological disorders.

Aberrant reward dynamics in trait anticipatory anhedonia

As a cardinal feature of several psychiatric disorders, anhedonia includes a consummatory component (deficits in hedonic response to rewards) and an anticipatory component (a reduced motivation to pursue them). Although being conceptualized as impairments of reward system, the neural characterization of reward processing in anhedonia is hampered by the enormous heterogeneity in the reward phase (‘wanting’ vs ‘liking’) and comorbidity (inherent to disease states). The current event-related potential (ERP) study examined the reward dynamics of anticipatory anhedonia in a non-clinical sample. Anticipatory and consummatory ERP components were assessed with a monetary incentive delay task in a high anticipatory anhedonia (HAA) group and a low anticipatory anhedonia (LAA) group. HAA vs LAA group showed a diminished reward-related speeding during behavioral performance and reported overall reduced positive affect during anticipation and receipt of outcomes. Importantly, neural dynamics underlying reward processing were negatively associated with anticipatory anhedonia across the anticipatory phase indexed by the contingent negative variation and the consummatory phase indexed by the feedback P3. Our results suggest that anticipatory anhedonia in non-clinical individuals is linked to a poor modulation during both anticipatory and consummatory phases of reward processing.

Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis

Accumulating evidence points towards the antipsychotic potential of cannabidiol. However, the neurocognitive mechanisms underlying the antipsychotic effect of cannabidiol remain unclear. We investigated this in a double-blind, placebo-controlled, parallel-arm study. We investigated 33 antipsychotic-naïve subjects at clinical high risk for psychosis (CHR) randomised to 600 mg oral cannabidiol or placebo and compared them with 19 healthy controls. We used the monetary incentive delay task while participants underwent fMRI to study reward processing, known to be abnormal in psychosis. Reward and loss anticipation phases were combined to examine a motivational salience condition and compared with neutral condition. We observed abnormal activation in the left insula/parietal operculum in CHR participants given placebo compared to healthy controls associated with premature action initiation. Insular activation correlated with both positive psychotic symptoms and salience perception, as indexed by difference in reaction time between salient and neutral stimuli conditions. CBD attenuated the increased activation in the left insula/parietal operculum and was associated with overall slowing of reaction time, suggesting a possible mechanism for its putative antipsychotic effect by normalising motivational salience and moderating motor response.

Feeling exhausted or vigorous in anticipation of high workload? The role of worry and planning during the evening

In this diary study, we focused on the anticipatory phase of the stress process. We investigated how work‐related worry and planning during the evening relate to next‐morning exhaustion and vigour, respectively. Moreover, we examined how afternoon workload anticipation is related to next‐morning exhaustion versus next‐morning vigour, depending on worry and planning in the evening. A sample of 112 employees took part in a daily diary study with three daily measurement occasions over two consecutive workweeks. Results of multilevel regression analyses showed that work‐related worry during the evening was positively related to next‐morning exhaustion. Moreover, worry interacted with workload anticipation in predicting next‐morning exhaustion: On days when worry was high, workload anticipation was positively related to next‐morning exhaustion. Work‐related planning was not related to next‐morning vigour and did not interact with workload anticipation in predicting next‐morning vigour. Our study suggests that work‐related worry is an important factor in the anticipatory phase of the stress process.Practitioner points On days when employees worry about their next workday during the evening, high workload may already be associated with employees’ well‐being even before employees are facing it. Worry about one’s next workday is associated with lower well‐being in the next morning, while planning one’s next workday is not associated with next‐morning well‐being. In anticipation of high workload, employees should refrain from worry about work during leisure time, for instance by engaging in absorbing leisure activities.

Skin conductance responses in anticipation of gains and losses

It has been observed that, in a variety of tasks, losses have a larger impact on behavior than do gains of equal size. This phenomenon is referred to as loss aversion. It is thought that the negativity bias in behavior is reflected in and potentially causally related to a negativity bias in emotional arousal. We examine skin conductance responses—a psychophysiological marker for emotional arousal—during the anticipation of gains and losses. In contrast to most previous research, gains and losses were separated from each other and symmetric in magnitude. We found that skin conductance responses during the anticipation phase increased with the magnitude of both gains and losses. Contrary to the predictions of the loss aversion hypothesis, the anticipation of a loss did not elicit stronger reactions than the anticipation of a gain of equal size.

Sympathetic Nervous System Response During Close Quarters Combat in Elite Military Men

Combat is physiologically stressful and associated with alterations and declines in several performance domains vital to the success of ground combat element (GCE) operations. Acutely, the body responds to stress via the “fight-or-flight” system, which alters activity of the autonomic nervous system (ANS) and can be monitored via heart rate variability (HRV). Currently, it is not well understood if ANS plays a role in the shooting performance of GCE operators. PURPOSE: To determine if HRV is correlated to shooting performance. METHODS: Active duty, elite GCE operators (n = 40) were recruited to participate in a 21-day close quarters combat (CQC) training program. Measures of HRV, marksmanship, and tactical/safety violations (errors) were recorded prior to (anticipation), during (execution), and immediately after (recovery) a similar shooting task on Day 1 and Day 21 of training. RESULTS: Heart rate was significantly less at every time point on Day 21 when compared to Day 1 (anticipation: −8.9%, execution: −11.5%, recovery: −8.6%; p < .05). The mean normalized low frequency power (LFnu)—a measure of sympathetic drive—was not different between days (p > .05), but it was significantly lower during the execution phase in comparison to the anticipation (−11.2%) and recovery phases (−12.0%, p < .05). The mean normalized high frequency power (HFnu)—a measure of parasympathetic modulation—was 14.9% higher in Day 21 compared to Day 1 (p < .05). In addition, the HFnu was 17.7% lower in the recovery compared to the execution phase (p < .05). The mean ratio of LF to HF (LF/HF) power was not different between days (p > .05), but it was significantly higher during recovery (35.4%) when compared to the execution phase (p < .05). Pearson product-moment correlation analysis revealed there was also a positive correlation between the LF/HF power ratio during the anticipation phase and the number of errors committed during execution on Day 1 (r = .635, p < .05). CONCLUSION: There is a positive correlation between sympathetic drive, during the anticipation phase of CQC training, and error rate at the onset of CQC training. These data suggest that those with a lower sympathetic tone perform better than those with a higher sympathetic tone.

Evaluation of mifepristone effects on alcohol-seeking and self-administration in baboons.

Mifepristone, a type II glucocorticoid receptor antagonist, is under investigation as a potential pharmacotherapy for alcohol use disorder. This study examined effects of chronic administration of mifepristone on alcohol-seeking and self-administration in large nonhuman primates. Adult baboons (n = 5) self-administered alcohol 7 days/week under a chained schedule of reinforcement (CSR). The CSR comprised 3 components in which distinct cues were paired with different schedule requirements, with alcohol available for self-administration only in the final component, to model different phases of alcohol anticipation, seeking, and consumption. Under baseline conditions, baboons self-administered an average of 1g/kg/day of alcohol in the self-administration period. Mifepristone (10, 20, and 30 mg/kg) or vehicle was administered orally 30 min before each CSR session for 7 consecutive days. In a separate group of baboons (n = 5) acute doses of mifepristone (10, 20, and 30 mg/kg) were administered, and blood samples were collected over 72 hr to examine mifepristone pharmacokinetics. Some samples also were collected from the baboons that self-administered alcohol under the CSR after the chronic mifepristone condition. Mifepristone did not alter alcohol-seeking or self-administration under the CSR when compared with the vehicle condition. Mifepristone pharmacokinetics were nonlinear, and appear to be capacity limited. In sum, mifepristone did not reduce alcohol-maintained behaviors when administered to baboons drinking 1g/kg daily. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

The state of the responsible research and innovation programme

Purpose Many of the ethical issues of additive manufacturing (AM) are not well known or understood, and there remains a policy vacuum that needs to be addressed. This paper aims to describe an approach that has been applied successfully to other emerging technologies, referred to as the responsible research and innovation (RRI) framework programme. A case is then made for the application of this approach in the AM industry with an illustration of how it might be used. Design/methodology/approach The research uses an RRI approach referred to as AREA, an acronym for Anticipate, Reflect, Engage and Act, to assess the ethical implications of AM. For the anticipation phase, horizon scanning was done to explore the ethical issues of AM based on extant literature, while reflective analysis was carried out all through the work to reflect on the data being collected and the research process. The engage phase involved interviews with five participants from small- and medium-sized enterprises (SMEs) involved in 3D printing. Findings The findings indicate that although AM appears to pose a threat to intellectual property rights, many in the industry do not care about this issue. As AM becomes mainstream, intellectual property will likely become a big problem. Also, very little is known about the health impacts of AM. This study shows that AM can be hazardous. Research limitations/implications Only users at SME level were sampled. Other researchers might test the usefulness of AREA at the enterprise level. Practical implications The research demonstrates how the AREA framework may be useful in information systems and social science research by enabling a more anticipatory and reflective research process. Originality/value The paper responds to the need for a novel approach to identifying ethical issues of AM.

What Role Does the Prefrontal Cortex Play in the Processing of Negative and Positive Stimuli in Adolescent Depression?

This perspective describes the contribution of the prefrontal cortex to the symptoms of depression in adolescents and specifically the processing of positive and negative information. We also discuss how the prefrontal cortex (PFC) activity and connectivity during tasks and at rest might be a biomarker for risk for depression onset in adolescents. We include some of our recent work examining not only the anticipation and consummation of positive and negative stimuli, but also effort to gain positive and avoid negative stimuli in adolescents with depression. We find, using region of interest analyses, that the PFC is blunted in those with depression compared to controls across the different phases but in a larger sample the PFC is blunted in the anticipatory phase of the study only. Taken together, in adolescents with depression there is evidence for dysfunctional PFC activity across different studies and tasks. However, the data are limited with small sample sizes and inconsistent findings. Larger longitudinal studies with more detailed assessments of symptoms across the spectrum are needed to further evaluate the role of the PFC in adolescent depression.

145. Social Cognitive Training Enhances Neural Activation Patterns Associated With Reward Processing in Schizophrenia

Amotivation in schizophrenia is a central predictor of poor functioning and is thought to occur due to deficits in anticipating future rewards, suggesting that impairments in anticipating pleasure can contribute to functional disability in schizophrenia. In healthy controls (HC), reward motivation is associated with anticipatory activity in frontal-striatal networks. By contrast, schizophrenia participants (SZ) show hypoactivation within these frontal-striatal networks during this motivated anticipatory brain state. Here, we investigated whether intensive computerized social cognitive training in schizophrenia could increase activity within frontal-striatal circuits to improve motivation during the anticipatory phase of stimuli that predicted upcoming reward.

Cookie or clementine? Psychophysiological stress reactivity and recovery after eating healthy and unhealthy comfort foods

Many people eat unhealthy foods that are high in calories, fat, or sugar when feeling stressed, yet little is known about whether this unhealthy comfort eating actually comforts. Additionally, prior research has not tested whether healthy comfort eating of fruits and vegetables might also alleviate stress, or whether comfort eating during the stress anticipation phase versus immediately after a stressful event is more beneficial for stress relief. The present experiment tested whether unhealthy and healthy comfort eating reduce acute psychophysiological responses to a socially evaluative stressor. Participants (N = 150 healthy women) underwent the Trier Social Stress Test in the lab and were randomly assigned to one of five conditions according to a 2 (food type: unhealthy vs. healthy) x 2 (eating timing: during stress anticipation vs. after the stressor) + 1 (no food control) between-subjects design. Stress outcomes included mood, cognitive appraisals, rumination, salivary cortisol, heart rate variability, and pre-ejection period. Unhealthy and healthy comfort eating did not dampen reactivity or enhance recovery of psychophysiological stress compared to control, and no differences in reactivity or recovery were found by comfort food type. Findings suggest that by replacing unhealthy comfort foods with fruits and vegetables, women will not be sacrificing any stress-reducing benefits and can inherently improve the quality of their diet while avoiding potential drawbacks of unhealthy comfort eating (e.g., links with abdominal obesity).

A biomechanical study of gait initiation in Down syndrome

BackgroundGait Initiation (GI) is a functional task that challenges the balance control requiring weight shift and a transition from standing to walking. Individuals with Down Syndrome (DS) walk with low velocity, prolonged stance and shorter steps beside an increased support base. However, no studies performed GI analysis on this population. The aim of this study is to quantitatively characterize the GI task in subjects with DS compared with a typically developed control group.MethodsSeventeen individuals with DS (17 to 40 years) and 19 healthy subjects (17 to 40 years) were enrolled in the study. Data were acquired using an optoelectronic motion capture system and force plates in order to measure the displacement and velocity of Center of Mass (CoM) and the trajectory of Center Of Pressure (CoP). All participants were asked to stand barefoot on the first force platform and received a verbal cue to begin walking for 6 gait initiation trials (three starting with each foot). The CoP duration, velocity, length and excursion were calculated during the anticipatory postural adjustments phases (APAs) and the locomotor (LOC) phase. For the analysis of the CoM, its displacements in antero-posterior (AP) and medio-lateral (ML) during the APAs and LOC phases. Statistical analysis was conducted to compare the two groups.ResultsRegarding CoP measures, when compared to control group, individuals with DS presented higher durations, lower velocities, longer lengths during the second APA and total phases, and shorter lengths during the first APA and LOC phases. The group with DS also presented longer CoP excursion during the second APA, whereas a shorter excursion was present during the first APA and LOC phases. The AP excursion in CoM is reduced in the participants with DS.ConclusionsOur results could be useful in the rehabilitation of individuals with DS as they suggest to reinforce exercise programs to improve balance in AP and ML directions, which is demonstrated to be impaired in these subjects.

Autonomic regulation in response to stress: The influence of anticipatory emotion regulation strategies and trait rumination.

According to the neurocognitive framework for regulation expectation, adaptively regulating emotions in anticipation of a stressful event should help individuals deal with the stressor itself. The goal of this study was twofold: first, the authors compared the influence of adaptive versus maladaptive anticipatory emotion regulation (ER) on the autonomic system during anticipation of, confrontation with, and recovery from a stressor; second, they explored whether trait rumination moderated this relationship. The authors collected data from 56 healthy female undergraduates during a public speaking task. The task involved 4 phases: baseline, anticipatory ER, stressor, and recovery. Participants were assigned to 1 of 2 anticipatory ER instructions (reappraisal or catastrophizing). Heart rate variability (HRV) indexed autonomic regulation. Results confirmed that HRV was higher in the reappraisal than in the catastrophizing group (over all time points, except for baseline). Trait rumination levels moderated the effect of anticipatory ER strategy on HRV during the stressor phase. Specifically, whereas for low ruminators reappraisal (versus catastrophizing) in the anticipation phase led to higher HRV when confronted to the stressor, high ruminators demonstrated lower HRV in that same condition. To conclude, over all participants, using reappraisal during the anticipation phase allowed participants to better cope with stress. However, only low, but not high ruminators could profit from the beneficial effect of anticipatory reappraisal on autonomic regulation. Even though further research is needed, this study suggests that, in female undergraduates, the tendency to ruminate is associated with abnormal anticipatory ER that might hinder an adaptive response to a stressor. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Individuals With Stroke Use Asymmetrical Anticipatory Postural Adjustments When Counteracting External Perturbations.

The authors investigated anticipatory postural adjustments in persons with unilateral stroke using external perturbations. Nine individuals with stroke and five control subjects participated. The electromyographic activity of 16 leg and trunk muscles was recorded. The onsets of muscle activity during the anticipatory phase of postural control were analyzed. The individuals with stroke did not show an anticipatory activation of leg and trunk muscles on the affected side; instead, the muscle onsets were seen after the perturbation, during the balance restoration phase. However, an anticipatory activation of muscles on the unaffected side was seen in individuals with stroke, and it was observed earlier compared with healthy controls (p < .05). The individuals with stroke showed a distal to proximal order of anticipatory activation of muscles on the unaffected side. The outcome of the study provides a basis for future investigations regarding ways of improving balance control in people with stroke.

Detailed analysis of skin conductance responses during a gambling task: Decision, anticipation, and outcomes.

Physiological arousal is considered a key factor of gambling behavior. Hence, to understand gambling behavior it is important to study the arousal responses during gambling. Moreover, crucial mechanisms of action could be uncovered by detailing the situations that produce an arousal response. A gamble, or bet, can be partitioned into three distinct phases: (a) decision phase, during which the information concerning the gamble is presented, outcomes are appraised, and a decision is made on how to gamble; (b) anticipation phase, during which the result of the gamble is awaited; (c) outcome phase, during which the outcome of the gamble is presented. Previous research on arousal responses to gambling have mostly measured tonic changes in arousal, and when phasic responses have been measured, analyses have generally concentrated on one of the gamble phases. The aim of the present study was to map the arousal responses during gambling in more detail by measuring skin conductance responses (SCRs) during all three gamble phases of a simple card game. The anticipation phase was found to produce the largest arousal response, suggesting anticipation to be a major contributor to arousal during gambling behavior. Risk behavior during the gambling task was mirrored in self-reported risk taking in everyday life, and risk-takers displayed smaller SCRs compared to nonrisk-takers during decision making, suggesting this as a possible biomarker for risk-taking individuals.

Designing and Staging High-Quality Park and Recreation Experiences Using Co-Creation

While the field of park and recreation has long been focused on designing and delivering quality leisure experiences, the concept of experiences has become increasingly salient across almost all industries over the last two decades. From the time that Pine and Gilmore initially proposed the concept of the experience economy in a 1998 Harvard Business Review article, experiences have become a primary driver of the economy (Pine & Gilmore, 1999; 2011). If an organization is not providing experiences perceived by consumers as high quality and desirable, the organization most likely will not survive. A core concept associated with the design of experiences is co-creation—a collaborative process of value creation between participants and providers (Payne, Storbacka, & Frow 2008; Prahalad & Ramaswamy, 2004a). This paper examines the concept of co-creation and its relevance for the field of park and recreation administration. This is accomplished by introducing a three-phased model of co-creation that spans over the three phases of leisure (i.e., anticipation, participation, and reflection) and discussing co-creation’s applicability to park and recreation settings through a descriptive case study. We define co-creation as active participation, dialogue, and collaboration between participants, producers, and a variety of other stakeholders throughout the process of designing, participating in, and reflecting on an experience (Prahalad & Ramaswamy, 2004b; Rossman & Schlatter, 2015). Based on the work of Duerden, Ward, and Freeman (2015), we propose a three-phased model of co-creation, which includes co-design during the anticipation phase of an experience, co-actualization during the participation phase of the experience, and co-curation during the reflection phase of the experience. This paper provides specific examples of the different forms of co-creation during each experience phase. This paper also introduces the DART (dialogue, access, risk assessment, and transparency) model of co-creation (Prahalad & Ramaswamy, 2002; 2004a; 2004c) and provides examples of its applicability for park and recreation professionals. This paper concludes with a case study exemplifying how co-creation and its associated concepts can be used to design a swim program experience. Although park and recreation professionals have a long history of designing and delivering experiences, they risk seeing their offerings become obsolete if they do not find ways to stay on the forefront of the experience economy. As more organizations come to view themselves as experience providers, the competition for people’s time and resources will increase. We hope the insights in this paper will help park and recreation professionals embrace and apply the concept of co-creation in their experience offerings. Subscribe to JPRA

All Aboard for "SAM": A New Anticipatory Conceptual Model for Passenger Preconsumption in Cruise Tourism

Anticipation in the cruise sector is nothing new, and passengers are most likely to have to wait for their trips after purchase. Anticipation theory has shown that levels of anticipation will initially be high after purchase then decrease, rising again before the event takes place. Extant research has considered anticipation but has not focused on changes in emotions in this anticipatory time phase. This study is particularly useful to cruise tour operators because of the lengthy booking periods in this sector compared to other holiday types. This research note considers anticipation theory and analyzes the impacts of anticipatory emotion with cruise passengers. It proposes a new Spiked Anticipation Model (SAM), which identifies how consumer anticipation can vary during the prejourney phase. SAM considers anticipatory emotions and time, and spikes are noted as the cruise anticipatory journey progresses. The research has also shown that there are a variety of both positive and negative anticipatory emotions that can be expressed during this stage. This investigation will extend academic understanding of anticipatory theory and provide cruise company managers with a clearer understanding of consumer emotions in this phase that will help them to identify which services and products their cruise passengers may require in this preconsumptive journey stage, thus potentially enhancing customer satisfaction and increasing revenues.

Evaluation of Sheep Anticipatory Response to a Food Reward by Means of Functional Near-Infrared Spectroscopy.

Simple SummaryAnticipatory behaviour to an oncoming food reward can be triggered via classical conditioning, implies the activation of neural networks, and may serve to study the emotional state of animals. This work aimed to investigate how the anticipatory response affects cerebral cortex activity in sheep. Eight ewes were conditioned to associate a neutral auditory stimulus (water bubble) to a food reward (maize grains). Then, sheep were trained to wait 15 s before accessing the food (anticipatory phase). Behavioural reaction and changes in cortical oxy-haemoglobin ([ΔO2Hb]) and deoxy-haemoglobin ([ΔHHb]) concentration were recorded by functional near infrared spectroscopy (fNIRS). During the anticipatory phase, sheep increased their active behaviour together with a cortical activation (increase of [ΔO2Hb] and a decrease of [ΔHHb]) compared to baseline. Sheep showed a greater response of the right hemisphere compared to the left hemisphere, possibly indicating frustration. Behavioural and cortical changes observed during anticipation of a food reward reflect a learnt association and an increased arousal, but no clear emotional valence of the sheep subjective experience.Anticipatory behaviour to an oncoming food reward can be triggered via classical conditioning, implies the activation of neural networks, and may serve to study the emotional state of animals. The aim of this study was to investigate how the anticipatory response to a food reward affects the cerebral cortex activity in sheep. Eight ewes from the same flock were trained to associate a neutral auditory stimulus (water bubble) to the presence of a food reward (maize grains). Once conditioned, sheep were trained to wait 15 s behind a gate before accessing a bucket with food (anticipation phase). For 6 days, sheep were submitted to two sessions of six consecutive trials each. Behavioural reaction was filmed and changes in cortical oxy- and deoxy-hemoglobin concentration ([ΔO2Hb] and [ΔHHb] respectively) following neuronal activation were recorded by functional near infrared spectroscopy (fNIRS). Compared to baseline, during the anticipation phase sheep increased their active behaviour, kept the head oriented to the gate (Wilcoxon’s signed rank test; p ≤ 0.001), and showed more asymmetric ear posture (Wilcoxon’s signed rank test; p ≤ 0.01), most likely reflecting a learnt association and an increased arousal. Results of trial-averaged [ΔO2Hb] and [ΔHHb] within individual sheep showed in almost every sheep a cortical activation during the anticipation phase (Student T-test; p ≤ 0.05). The sheep showed a greater response of the right hemisphere compared to the left hemisphere, possibly indicating a negative affective state, such as frustration. Behavioural and cortical changes observed during anticipation of a food reward reflect a learnt association and an increased arousal, but no clear emotional valence of the sheep subjective experience. Future work should take into consideration possible factors affecting the accurateness of measures, such as probe’s location and scalp vascularization.

Predictive Modulation of Corticospinal Excitability and Implicit Encoding of Movement Probability in Schizophrenia.

The ability to infer from uncertain information is impaired in schizophrenia and is associated with hallucinations and false beliefs. The accumulation of information is a key process for generating a predictive internal model, which statistically estimates an outcome from a specific situation. This study examines if updating the predictive model by the accumulation of information in absence of feedback is impaired in schizophrenia. We explored the implicit adaptation to the probability of being instructed to perform a movement (33%-Go, 50%-Go, or 66%-Go) in a Go/NoGo task in terms of reaction times (RTs), electromyographic activity, and corticospinal excitability (CSE) of primary motor cortex (M1). CSE was assessed at two time points to evaluate prediction of the upcoming instruction based on previously accumulated information: at rest (preceding the warning signal) and at the Go/NoGo signal onset. Three groups were compared: patients with schizophrenia (n = 20), unaffected siblings (n = 16), and healthy controls (n = 20). Controls and siblings showed earlier movement onset and increased CSE with higher Go probability. CSE adaptation seemed long-lasting, because the two CSE measures, at least 1500 ms apart, strongly correlated. Patients with schizophrenia failed to show movement onset (RT) adaptation and modulation of CSE. In contrast, all groups decreased movement duration with increasing Go probability. Modulation of CSE in the anticipatory phase of the potential movement reflected the estimation of upcoming response probability in unaffected controls and siblings. Impaired modulation of CSE supports the hypothesis that implicit adaptation to probabilistic context is altered in schizophrenia.