Fungal periprosthetic joint infections (PJI) are very rare with a paucity of instructive evidence on successful treatment modalities. Use of antibiotic impregnated bone cement spacers in cases of bacterial PJI is well reported. We reviewed the current literature on the application of anti-fungal bone cement in cases of fungal PJI. Seven cases were identified: three total hip arthroplasties and four total knee arthroplasties, with a mean patient age of 63.1 yr (42–75), median prosthesis age of 32 mo and median duration of symptoms of 18 mo. Resection arthroplasty was performed in all patients, with successful reimplantation in five, and all were infection free at last follow-up, median 17 mo (3–84 mo). Anti-fungal bone cement appears to be a safe and potentially effective adjunct to current treatment strategies for fungal PJI.