Anti-aging Products Research Articles

The Importance of Some Plant Extracts as Skin Anti-aging Resources: A Review.

Skin is the largest and most visible organ of the body. Many of its functions include temperature regulation, immunity from microorganisms, maintaining electrolyte balance, and protection from physical injuries, chemical agents and ultraviolet (UV) radiation. Aging occurs in every layer of the skin, primarily due to the degradation of its components. Induction of degradative enzymes and the abundant production of reactive oxygen species lead to skin aging. Understanding the complexity of skin structure and factors contributing to the skin aging will help us impede the aging process. Applications of anti-aging products are a common method to prevent or repair damages that lead to aging. This review will provide information on the causes and indicators of skin aging as well as examine studies that have used plants to produce anti-aging products.

The effect of content and model type in sidebar advertising on middle-aged women’s online purchases of anti-aging products

The effect of content and model type in sidebar advertising on middle-aged women’s online purchases of anti-aging products

Anti-Aging Liposomal formulation: A Mini Review

Due to very intensive and technological industrial development, different preparation techniques are being introduced to the pharmaceutical/ cosmeceutical industry. Lipid-based formulation cover most of the formulations based on cosmetics products. They are primarily used in antiaging products. Liposomes used as a carrier for anti-aging and cosmeceutical formulations in order to exhibit better absorption properties by the skin than the standard cosmeceutical products. The use of liposomes in Cosmeceutical preparations is a promising technique for the formulation of more effective anti-aging products with less side effects, improved stability and a targeted delivery of the active component.

Ultrasonication extraction, bioactivity, antioxidant activity, total flavonoid, total phenolic and antioxidant of Clitoria Ternatea linn flower extract for anti-aging drinks

Background: Anti-aging health drinks currently are one of the largest consumer drinks. People are more concerned about their health and quality of health life in order to increase longevity. We have investigated that many anti-aging health drink products in Thailand are developed below the standard and do not meet the Thai FDA requirements in terms of bioactivities and toxicity analysis. Objective: This study aimed to evaluate the bioactivity quantities, active ingredients, total phenolic contents, and different extraction methods essential to obtain definite value of bioactivities, quantified antioxidant activity, and also acute toxicity analysis of Clitoria ternatea Linn flower extract drink. Materials and Methods: We performed ultrasonication extraction and maceration with 40% and 50% ethyl alcohol in different periods of time and also analysis of antioxidant activities with 2,2-diphenyl-1-picrylhydrazyl, ferric-reducing antioxidant power, and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid methods, total phenolic compound, active in gradients by high-performance liquid chromatography (HPLC). Results: We found that C. ternatea Linn flower extract drink consisted of high contents of gallic acid and rutin by HPLC method. There was no acute toxicity of C. ternatea Linn flower extract health drink. Abbreviations used: DPPH: 2,2-diphenyl-1-picrylhydrazyl; FRAP: Ferric-reducing antioxidant power; ABTS: 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid; HPLC: High-performance liquid chromatography; EtOH: Ethanol; PTZ: (2,4, 6—tripyridyl—striazine); CH3OH: Acetic acid; CH3OH: Methyl alcohol.

Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study.

BackgroundSkin aging is accelerated by multiple extrinsic factors: ultraviolet radiation, smoking and pollution increase oxidative activity, damaging cellular and extracellular components such as DNA, proteins, and lipids. With age, collagen and hyaluronic acid levels decline, resulting in loss of elasticity and moisture of the skin. Over time this damage leads to characteristic signs that make the skin look older: altered facial contour, sagging skin, wrinkles, and an uneven complexion. This study evaluated the anti-aging effects of a new facial cream formulated with carnosine, Alteromonas ferment extract, crosspolymer hyaluronic acid, and a tripeptide.MethodsAn open-label intra-individual study to assess the anti-aging efficacy of the investigational product in 33 women aged 45 to 65 years. The product was applied twice daily for 56 days. Facial contour and skin deformation, elasticity, hydration, and complexion were measured with specialized equipment at baseline and days 28 and 56. Additionally, subjects completed questionnaires at days 28 and 56 on the perceived efficacy and cosmetic characteristics of the product.ResultsAfter 56 days of use of the investigational product, a redefining effect was observed, with a significant decrease in sagging jawline (7%). Skin was significantly more hydrated (12%), firmer (29%), and more elastic (20%) (P<0.001 for all). On complexion assessment, skin texture (a measure of skin smoothness) and spots (brown and red skin lesions) also improved significantly (12% and 6% decrease, respectively). In the subjective self-evaluation, the majority of subjects reported that the skin was visibly tightened and more elastic, flexible, and moisturized (91%, 88%, 91%, and 90%, respectively). The product was well tolerated with no adverse events reported during the study.ConclusionThis new cosmetic product demonstrated anti-aging effects after 56 days of use, most notably a redefined facial contour and improved complexion. It is a safe and effective anti-aging product.

The relationship between container colors and the beauty benefits of skin care products

AbstractThis study explored the best color selections to match the benefits of beauty products based on rankings obtained from an experimental perception of different skin care product containers. Gender (64 males, 75 females) and cultural (76 Taiwanese, 63 Malaysians) differences were also compared, aiming to explore color associations and emotional bonding by using psychophysical testing methods. A survey of 205 market samples showed that nearly half of the existing skin care product containers had a white body color. White appeared frequently on containers for skin whitening, firming, exfoliating, antiaging, and antiacne products. However, skin moisturizing products used an equal amount of white and blue on their containers. The psychophysical experiment results showed that participants felt that white best matched skin whitening products, red matched skin firming and antiaging products, blue matched skin moisturizing products, black matched exfoliating products, and green matched antiacne products. Neither gender nor cultural differences were found to be significant. Comparing the results with color emotion studies, it was found that (1) for color emotion weight, firming products were related to heaviness, whereas whitening products were connected to lightness; (2) for color emotion heat, whitening, moisturizing, exfoliating and antiacne products were aligned with coolness; and (3) for color emotion activity, product container colors were not related, except slightly for firming products. These findings suggest that psychological responses to color meaning are context‐ and experience‐dependent, meaning that selection of colors to match beauty benefits is based more on people's expectations of the products than their color emotion response.

Aloe Vera-Induced Hepatotoxicity

Introduction: Herbal supplementation has been widely used by the general population as a safe and natural alternative to medications. Aloe Vera has been used as a sunburn reliever, laxative and in anti-aging products. Many herbal supplements have been linked to cause acute liver injury. Case presentation: We present a 52 year old male with history of hypertriglyceridemia who presented to our emergency department with complains of epigastric pain for 2 weeks duration. The patient described the pain as an intermittent sharp pain, 8/10 intensity, worse with food intake and no radiation. The Patient denied fever, chills, nausea, vomiting, diarrhea, constipation, melena or dysuria. The patient denied alcohol intake, acetaminophen or NSAIDS use. On further questioning patient revealed taking Aloe Vera extract to help with his abdominal pain. On arrival at the emergency room, his vitals were stable and he was afebrile. Laboratory workup was significant for an ALT of 837, an AST of 928, an a ALP of 175, a total bilirubin 1.6. an INR of 1.0. and a Lipase 473. CT of the abdomen showed fatty infiltration without focal lesion in the liver, cholelithiasis, with normal sized common bile duct. No evidence of pancreatitis seen. Workup for liver disease including viral hepatitis, acetaminophen level, iron studies, ceruloplasmin, ANA, AMA, ASMA, LKM AB, immunoglobulins were all normal. The patient was advised to stop taking Aloe Vera and was monitored in the hospital for 2 days with resolution of his symptoms. On two months follow up, the patient was asymptomatic and his LFTs are back to normal limits. Discussion: Patients usually take herbal supplementation with assumption that it is safe. Without careful history taking, many patients won't admit to using herbal supplementation. Establishing a definitive causative relationship between herbal supplement and hepatotoxicity is very challenging as a re-challenge may be unethical. Using the Roussel Uclaf Causality Assessment Method for determining drug hepatotoxicity (RUCAM) scale our patient scored 8 points which placed Aloe-vera as a “probable” cause of hepatotoxicity in our patient\ Conclusion: Herbal supplementation should be considered and investigated in patients presenting with hepatotoxicity. Careful history taking may reveal otherwise hidden causes of acute hepatis.

Start-up sues L’Oréal over antiaging ingredient

A religious group has filed suit against L’Oreal claiming that the cosmetics giant infringed on patents covering use of the nucleoside adenosine in wrinkle-erasing creams that the charity sells to raise money for the poor. L’Oreal says it did not violate the group’s patents. According to the suit, filed in Delaware federal court, the Massachusetts-based Teresian Carmelites introduced Easeamine, a high-end antiwrinkle cream containing adenosine, in 2009. Easeamine sales were initially strong, say the Teresians, who describe themselves as a “Christian monastery dedicated to prayer, contemplation, and service to the poor.” But in 2010, as the Teresians were about to expand their skin care line, L’Oreal launched its competing Youth Code brand of antiaging skin products featuring adenosine. Sales of Easeamine, through the Teresians’ for-profit Carmel Labs arm, didn’t meet the group’s expectations, and they were unable to pay their monastery’s mortgage. Adenosine has long been known to play an

052 Microemulsion: A new-type of formulation dedicated to skin anti-aging products

052 Microemulsion: A new-type of formulation dedicated to skin anti-aging products

Galangin suppresses H2 O2 -induced aging in human dermal fibroblasts.

Human skin aging is a progressive process that includes intrinsic aging and extrinsic photodamage, both of which can cause an accumulation of reactive oxygen species (ROS), resulting in dermal fibrosis dysfunction and wrinkle formation. Galangin is a flavonoid that exhibits anti-inflammatory and antioxidative potential. Previous studies have reported that galangin has antioxidative activity against ROS-mediated stress. The aim of the present study is to determine the antiaging effects of galangin on dermal fibroblasts exposed to H2 O2 . In this study, we established a hydrogen peroxide-induced inflammation and aging model using human HS68 dermal fibroblasts. Stimulation of fibroblasts with H2 O2 is associated with skin aging and increased expression of inflammation-related proteins, along with downregulation of collagen I/III formation and expression of antioxidative proteins. Galangin effectively reduced NF-κB activation, the expression of inflammation-related proteins and cell aging. Galangin also reversed H2 O2 -activated cell senescence in HS68 cells. Our results reveal that galangin protects human dermal fibroblasts by inhibiting NF-κB activation, decreases the expression of inflammatory factors and upregulates IGF1R/Akt-related proteins, indicating that galangin may be a potential candidate for developing natural antiaging products that protect skin from damage caused by ROS.

Patient interest in and familiarity with anti-aging therapies: Asurvey of the general dermatology clinic population.

The appearance of aging skin is a common complaint among dermatology patients. There is an expanding market for anti-aging therapies, but little information is available regarding which patients utilize these treatments and patient preferences regarding treatment. To describe the patient population utilizing anti-aging therapies, assess patient familiarity with treatment options, and learn where treatment information is most often obtained. Three hundred patients were surveyed in the University of Michigan General Dermatology Clinic. Fifty-three percent of the general dermatology patient population has used an anti-aging treatment in the past; 66% reported interest in the future use. Interest is high among all genders, ages, and incomes. Most subjects obtained treatment information from magazines, but subjects were more likely to pursue treatment if information was obtained from a dermatologist. Demographics of anti-aging therapy are changing, and a wide variety of patients pursue treatment. Patients are largely unfamiliar with most treatment options and are more likely to pursue treatment after receiving treatment information from a dermatologist. The information presented in this study is helpful to both dermatologists and marketers of anti-aging products.

Nanoemulsion Containing SangYod Rice Bran Oil and Thanakha Extracts: &lt;i&gt;In Vitro &lt;/i&gt;Antioxidant and Irritation Assessments

Nanoemulsions are well characterized in a promising drug delivery system with applications for drug and cosmetic. Traditionally and cosmetic industries use Rice bran oil and Hesperethusa crenulata or Thanakha bark aqueous extract in sunscreen formulations, anti ageing products and in treatments for skin diseases. The aim of this study was to produce the nanoemulsion and to evaluate their physical stability, irritation potential. In vitro study, the total phenolic contents and total antioxidant capacity of SangYod Rice bran oil (SRBO) were 1130.44 ± 53.55 mg GAE/mg and 25.94±4.69 mmol TEAC/mg and Thanakha were 3.85±0.23 mg GAE/gdw and 19.87 ± 2.59 mmol TEAC/gdw, respectively. The nanoemulsion containing SRBO and Thanakha, oil in water, was produced using low-pressure homogenizer and ultrasonicator techniques and the particle size was 167.03±1.75 nm. The stability of nanoemulsion represented no significant change on pH and particle size after day 0, 5, 11, 14 and over 12 month at temperature 4, 25 and 40 °C. Moreover, it’s also showed no irritation on HET–CAM test, a basic test for embryotoxicity, systemic toxicity and immunopathology. Conclusion, these results suggested that the nanoemulsion containing SRBO and Thanakha may serve as potential vehicles for improved transdermal delivery antioxidant compound and no irritation.

Comparison of metrological techniques for evaluation of the impact of a cosmetic product containing hyaluronic acid on the properties of skin surface.

The aim of this research was to evaluate mutual interchangeability of four principally different biometric instrumental techniques designed for objective measurement of changes in the physical, mechanical, and topographical properties of the skin surface treated with commercial antiaging cosmetic products with hyaluronic acid. The following instrumental devices were used: Visioscope PC 35, Corneometer Multiprobe Adapter MPA 6, Reviscometer RVM 600, and 3D scanner Talysurf CLI 500. The comparison of the individual methods was performed using cluster analysis. The study involved 25 female volunteers aged 40-65. Measurements were taken before and after 30 daily in vivo applications of an antiaging preparation to the skin surface in the periorbital area. A slight reduction in skin surface roughness was recorded in 55% of the volunteers. On the contrary, a worsening from their initial states was detected in 25% of the subjects, while for 20%, no significant change was reported. Cluster analysis confirmed that the mentioned methodologies can be divided into two basic clusters, namely, a cluster of methods recording the changes in skin relief by means of optical techniques, and a cluster of methods investigating changes in hydration and anisotropy. In practice, the techniques in different clusters are not interchangeable and should be assessed separately.

Efficacy and cutaneous acceptability of a skincare antiaging product with retinaldeyde 0.1%, sodium hyaluronate and ascophylline

Efficacy and cutaneous acceptability of a skincare antiaging product with retinaldeyde 0.1%, sodium hyaluronate and ascophylline

Over-the-counter antiaging products: Science and fiction

Both the passage of time (intrinsic ageing) and chronic exposure to environmental insults (extrinsic ageing) induce changes in skin appearance, mechanical function and architecture. In the case of intrinsic ageing these clinical signs are associated with a generalised loss of dermal extracellular matrix (ECM) components including fibrillar collagens, elastic fibres and negatively charged oligosaccharides. In contrast extrinsically aged skin is characterised by the early loss of fibrillin-microfibrils from the papillary dermis and, in more severe cases, by the accumulation of dis-organised elastotic material known as solar elastosis.

In vitro and cellular activities of the selected fruits residues for skin aging treatment.

Peel extracts of litchi and rambutan, and that of tamarind seed coat were investigated in relation to their utility in skin-aging treatments. Standardized extracts of tamarind were significantly (p < 0.05) more efficient at O2 •- scavenging (IC50 = 27.44 ± 0.09) than those of litchi and rambutan (IC50 = 29.57 ± 0.30 and 39.49 ± 0.52 μg/ml, respectively) and the quercetin standard (IC50 = 31.88 ± 0.15 μg/ml). Litchi extract proved significantly (p < 0.05) more effective for elastase and collagenase inhibition (88.29 ± 0.25% and 79.46 ± 0.92%, respectively) than tamarind (35.43 ± 0.68% and 57.69 ± 5.97%) or rambutan (31.08 ± 0.38% and 53.99 ± 6.18%). All extracts were safe to human skin fibroblasts and inhibit MMP-2, with litchi extract showing significantly (p < 0.01) enhanced inhibition over the standard, vitamin C (23.75 ± 2.74% and 10.42 ± 5.91% at 0.05 mg/ml, respectively). Extracts suppress melanin production in B16F10 melanoma cells through inhibition of tyrosinase and TRP-2, with litchi extract being the most potent, even more so than kojic acid (standard). These results highlight the potential for adding value to agro-industrial waste, as the basis for the sustainable production of innovative, safe, anti-aging cosmetic products.

Marine Microbial-Derived Molecules and Their Potential Use in Cosmeceutical and Cosmetic Products.

The oceans encompass a wide range of habitats and environmental conditions, which host a huge microbial biodiversity. The unique characteristics of several marine systems have driven a variety of biological adaptations, leading to the production of a large spectrum of bioactive molecules. Fungi, fungi-like protists (such as thraustochytrids) and bacteria are among the marine organisms with the highest potential of producing bioactive compounds, which can be exploited for several commercial purposes, including cosmetic and cosmeceutical ones. Mycosporines and mycosporine-like amino acids, carotenoids, exopolysaccharides, fatty acids, chitosan and other compounds from these microorganisms might represent a sustainable, low-cost and fast-production alternative to other natural molecules used in photo-protective, anti-aging and skin-whitening products for face, body and hair care. Here, we review the existing knowledge of these compounds produced by marine microorganisms, highlighting the marine habitats where such compounds are preferentially produced and their potential application in cosmetic and cosmeceutical fields.

Transcription factor p53 and skin aging

The review is dedicated to one of the molecular factors of skin aging essential for cosmetic medicine for the elderly. Cell renewal processes slow down with aging, and the proliferation–apoptosis equilibrium shifts towards cell death. One of the pivotal apoptotic markers is transcription factor p53. Its expression in skin keratinocytes increases under the influence of ultraviolet radiation. Mutant forms of p53 have been revealed in 70% of keratinocytes of skin exposed to ultraviolet radiation. On the one hand, suppression of p53 expression decreases apoptosis in skin cells, thereby decelerating senescence. On the other hand, it promotes the development of neoplasms in the skin. Thus, support of the physiological balance of p53 expression in skin cells is important for theoretical and practical gerontocosmetology. In addition, p53 can be used as a marker for skin cell functionality in response to anti-aging cosmetic products and to instrumental cosmetology.

Anti-oxidative, acetylcholinesterase and pancreatic lipase inhibitory activities of compounds from Dasiphora fruticosa, Myricaria alopecuroides and Sedum hybridum

Total of 35 phenolics and flavonols were isolated from flowers and leaves of Dasiphora fruticosa Rydb., from branches of Myricaria alopecuroides Schrenk. and from the herb of Sedum hybridum L. The isolated compounds were identified on the basis of spectral data and tested for their anti-oxidative, acetylcholinesterase and pancreatic lipase inhibitory activities.Quercetin glycosides, gallic acid, (-)EGCG and gossypetin-8-O-xylopyranoside tellimagrandin II exhibited strong anti-oxidative activity by the DPPH scavenging method. The acetylcholinesterase inhibitory activity of quercetin glycosides and (-)EGCG was higher than those of other compounds. Whereas, tellimagrandin II, (-)EGCG and gallic acid derivatives exhibited the most potent inhibitory activity against the pancreatic lipase enzyme among the isolated compounds. Only (-)EGCG showed a prominent activity against all assayed experiments. It was concluded that these plants could be studied further for their potential as anti-oxidative, anti-aging and lipid lowering active products.

Development of a Topical Resveratrol Formulation for Commercial Applications Using Dendrimer Nanotechnology.

Resveratrol (RSV) is well known for its anti-oxidant and anti-aging properties. However, resveratrol is insoluble in water and has stability issues. Recently, efforts were placed to prepare a resveratrol-based advanced anti-aging topical product but it contains harsh organic solvents and oils that could be harmful to the human body and the environment. Hence, we propose the use of a multifunctional dendrimer to solve the solubility and stability issues of resveratrol. A dendrimer-resveratrol complex was prepared, optimized and tested for solubility enhancement, stability in solution and cream dosage forms. We have also developed a high performance liquid chromatography method to measure the resveratrol within the final product. PAMAM dendrimers increased the solubility and stability of resveratrol in water and semisolid dosage forms. Therefore, this product would be water based ‘green’ formulation devoid of harsh organic solvents and oils and can be safely applied to the skin. Additionally, we have shown that the dendrimer helped to increase overall RSV loading and skin penetration of resveratrol. The dendrimer-RSV formulation was successfully scaled up towards commercialization. Dendrimer with RSV has led to an innovation in anti-aging cream and solutions that could be commercially marketed. Dendrimer-RSV complex could also be added to other product forms for additional purposes and applications.