In this work, we propose an Nd-doped double-layer anti-resonant phosphate fiber with a core diameter of 50 µm for high-power single-mode 900 nm laser generation. Double-layer interlaced anti-resonant elements were designed here to enhance the fundamental mode confinement capability of the large-mode-area Nd-doped fiber core. Moreover, a double-layer F-P etalon formed between the anti-resonant elements and the inner cladding was analyzed for the first time for fiber loss manipulation. Single-mode operation in the 890–907 nm band with confinement loss lower than 0.1 dB/m can be achieved from the designed fiber. More importantly, high confinement loss larger than 100 dB/m is achieved for all the fiber modes around 1060 nm for four-level gain competition suppression in 900 nm Nd-doped fiber laser generation. A 900 nm fiber amplifier simulation based on the designed Nd-doped phosphate fiber shows that the parasitic lasing or even amplified spontaneous emission around 1060 nm can be effectively suppressed and a high-efficiency hundred-watt laser at 900 nm can be anticipated.