This study was conducted to investigate the potential of Aframomum melegueta leaf and seed as biopesticide against Sitotroga cerealella infestation on two paddy varieties at ambient temperature of 28 °C ± 2 °C and relative humidity of 75 ± 5%. The two paddy varieties used were FARO 44 and FARO 52. Leaf and seed powders of A. melegueta were made at 0.1, 0.2, 0.4, 0.6 and 0.8 g while the extracts were made at 1, 2, 3, 4 and 5%. Mortality of the insect on the two paddy varieties was record after 24, 48 and 72 h of application of the powders and extracts of this plant. The highest number of the insect was observed on FARO 52 treated with seed powders and extracts of A. melegueta. Only the seed extracts were able to achieve 100% moth mortality within 72 h of application at 4% concentration and were significantly (p < 0.05) different from others. The powders and extracts of the plant significantly reduced or prevented the adult emergence of the insect and increased their developmental period as well reduced or prevented seed weight loss with seed powders and extracts having the greatest effect on the paddy variety FARO 44. The antinutritional components present in the two paddy varieties include phytate, oxalate, total phenol and tannin cyanide, and the amylase content was also determined, with FARO 44 having the highest value of 17.31, 0.18, 0.43, 10.46 and 5.49 for phytate, oxalate, tannin, cyanide and amylase content, respectively. Powders and extracts of A. melegueta could be introduced into pest management techniques since they are effective against S. cerealella.