Now days a herbal and traditional medicines mostly used in all over the world according to WHO, about 60 to 65% world population practicing herbal and traditional medicines. Vitex negundo Linn. is an aromatic herb belong to family Verbenaceae. It is also known as Nirgundi, Five leaved chaste tree. Plants have many chemical constituents as flavonoids, volatile oil, triterpenes, diterpenes, sesquiterpenes, lignan, flavones, glycosides, iridoid glycosides and stilbene derivative. These chemical constituents are present in each part of the plant. Vitex negundo extract have various pharmacological activities such as anti-inflammatory, antipyretic, anti-arthritic, antioxidant, analgesic activity, antibacterial activity, antitumor activity, anti-amnesic activity, anxiolytic activity, Nephroprotective activity, anti-HIV activity, Antitubercular activity, antieosinophilic activity, anti-snake venom activity. This review article provides depth information related to plant morphology, cultivation, chemical constitutes, pharmacological activities and their medicinal uses.
 Keywords: Vitex negundo, Nirgundi, Casticin, Anti-Gout Activity