The article presents the description of three clinical cases of the successful treatment of toe onychomycosis and athlete's foot of various etiologies using 5% amorolfine antifungal nail lacquer. The first case: a 31-year-old woman was diagnosed with white superficial onychomycosis of great toe caused by T.rubrum. The treatment with 5 % amorolfine once a week for 6 months resulted in full recovery. The initiation of long-term preventive therapy with 5 % amorolfine lacquer prevented from recurrent toe onychomycosis.The second case: a 42-year-old woman developed onychomycosis after the application of decorative coating on her nails; onychomycosis was caused by Scopulariopsis brevicaulis. She was treated with itraconazole pulse therapy and 5% amorolfine lacquer. She fully recovered.
 The third case: a 65-year-old man with total onychomycosis of 10 toes developed the skin mycosis of the left foot and lower third of the leg. He was prescribed a therapy with sertaconazole cream and 5 % amorolfine lacquer. The use of 5 % amorolfine lacquer was continued to prevent from recurrent dermatomycosis.Thus, the above mentioned cases are a good example of the advantages of using 5% amorolfine lacquer in the treatment of most toe onychomycosis types caused by any pathogens (dermatophytes, yeasts or molds).