Study of the Antifungal Action of the Lacquer Based on the GABA Derivative of 2-Chloro-N-(9,10-Dioxo-9,10-Dihydroanthracen-1-yl)Acetamide

Abstract

Onychomycosis is one of the most acute problems of modern medicine, which accounts for about 50% of all nail diseases. Fungi of dermatophytes of the genus Trichophyton are the most studied etiological factor of onychomycosis. Non-dermatophytes can also cause onychomycosis. Fungi of the genus Aspergillus is one of the main pathogens among the non-dermatophytes agents of onychomycosis. Antifungal nail lacquer is the most optimal dosage form for the topical treatment of onychomycosis. GABA derivative of 2-chloro-N-(9,10-dioxo-9,10-dihydroanthracen-1-yl)acetamide was used as a perspective antifungal agent in the form of lacquer. The antifungal action of the obtained lacquer containing compound 2 against fungus strain Aspergillus niger VKM F-1119 was compared with the known antifungal lacquer “Lamisil” containing terbinafine as the active agent. Investigation of the antifungal action was carried out at concentrations of 1%, 0.5%, and 0.1% of compound 2 and terbinafine using the diffusion in agar technic after 24 h and 72 h. It has been determined that derivative 2, as well as terbinafine at a concentration of 1%, caused fungicidal action after 24 h and fungicidal and fungistatic effect after 72 h.