Anti-aging Ability Research Articles

Improved selectivity and anti-aging ability for 6FDA type carbon molecular sieve membranes by mixing silicon from macro-phase separation to molecule doping

Good gas separation performance and anti-aging ability are important for the applications of carbon molecular sieve membrane (CMSM). In this work, silicon atoms in the form of siloxane-Cl are introduced into 6FDA-DABA type polyimide (PI) precursor membrane, and benzimidazoles (BI) is copolymerized into PI to effectively improve the compatibility between PI and siloxane-Cl. By varying the content of siloxane-Cl, the composite membrane changes from macro-phase separation to molecule level miscibility, which leads to the formation of silicon-rich interface layer and silicon molecule doping after high temperature pyrolysis, respectively. The residual silicon content in CMSM could be as high as 1 wt%. The high content silicon doped CMSM exhibits much improved H2 permeability retention degree (3617 Barrer of H2 permeability, 62% higher) and H2/CH4 selectivity (138, 51% higher) as compared to control CMSM after 45 days of physical aging. This work proves that the incorporation of silicon in CMSMs in proper forms could significantly improve their molecular sieving and anti-aging performances; a higher content of residual silicon and molecule level doping are highly desired. The heteroatom doping is expected to pave a new way for finely tuning the micro-structures of CMSMs and improving gas separation performances.

Evaluating the low-temperature creep properties of polyphosphoric acid-polymer composite-modified asphalt

ABSTRACT The objective of this study was to explore the effect of polyphosphoric acid (PPA) on the low-temperature creep properties of styrene–butadiene-styrene (SBS) and crumb rubber (CR)-modified asphalt binder. PPA-SBS and PPA-CR composite-modified asphalt with different PPA contents were prepared by a high-speed shear method. The low-temperature properties of composite-modified asphalt were studied by bending beam rheometer (BBR) test, and the test results were fitted by the Burgers model to assess the creep property of the asphalt. From the test results, it is demonstrated that the low-temperature properties of polymer-modified asphalt were weakened after PPA was added. At low temperatures, the stiffness modulus (S) of PPA-CR composite-modified asphalt was half that of PPA-SBS, and the creep rate (m) was more than 9.4% higher. The results of relaxation time ( λ ), dissipated energy ratio (DER), and the derivative of creep compliance (J’(t)) showed that the creep property of PPA-CR composite-modified asphalt is better than that of PPA-SBS and SBS-modified asphalt at low temperatures. Moreover, the antiaging ability of polymer-modified asphalt was also ameliorated by incorporating PPA, regardless of SBS or CR.

Effect of Basalt Fiber Content and Length on the Strength and Crack Development of Polyvinyl Alcohol/Basalt Hybrid Fiber-Reinforced Cement Soil.

Polyvinyl alcohol (PVA) fiber is widely used in geotechnical engineering because of its excellent physical and mechanical properties; however, PVA fibers are prone to aging, while basalt fiber has a natural anti-aging ability, which can be added to cement material to effectively eliminate the effects of aging on PVA fiber. Previous experiments identified that the optimum content of PVA fiber is 0.5% (mass fraction, the same below). Based on this, we continued to add basalt fibers of different lengths (3 mm, 6 mm, 9 mm, 12 mm, 18 mm, 30 mm) and different contents (0%, 0.25%, 0.5%, 0.75%, 1%) to study the effect of both length and content of basalt fibers on the strength of cement soil specimens. It was concluded that adding 0.5 % of 9 mm basalt fiber results in the greatest increase in unconfined compressive strength (UCS). The UCS reached 12.59 MPa, which was 71% higher than specimens without fiber, and a regression analysis was carried out to obtain the relationship among them. The ratio of cement soil in the highest UCS and the relationship among the UCS, the length, and the content of basalt fiber can be used as a reference for practical projects. In addition, digital image correlation (DIC) technology was used to analyze the surface cracks and horizontal strain field when the peak strain was reached at each content and length of the basalt fiber. Finally, the curing mechanism for hybrid fiber cement soil was analyzed by combining the results of the UCS test, DIC test, and SEM test.

Anti-aging effects of the pistachio extract on mesenchymal stem cells proliferation and telomerase activity

PurposeUsing mesenchymal stem cells (MSCs) is a promising method in regenerative medicine. Limited proliferation and aging process of MSC are the most common problems in MSCs application. In the present study, we intend to investigate the anti-aging properties of pistachio pericarp in bone marrow-derived MSCs of old male rats. Materials and methodsFirst, 1000, 2000, and 3000 µg/mL AEPP were used to treat MSCs derived from bone marrow for 24 h at 37 °C. Then, cell viability, population doubling time, the percentage of senescent cells, telomere length, telomerase activity, and the expression of TRF1 and RAP1 when bone marrow-derived MSCs treated with AEPP were investigated. ResultsThe results showed that cell viability increased when MSCs derived from bone marrow were treated with 2000 and 3000 µg/mL AEPP, indicating this extract may stimulate proliferation. The population doubling time was also enhanced with an increase in AEPP concentration. Importantly, an increase in AEPP concentration significantly reduced senescent cell percentage. Telomere length, telomerase activity, and the expression of anti-aging genes were significantly increased with the increase of AEPP dose. ConclusionTaken together, AEPP has been used as a natural compound with excellent proliferation and anti-aging ability in MSCs. As new therapeutic candidates with promising effects, it can be used with high safety by multiplying cells and delaying the aging process. However, more studies are needed and the anti-aging effects of this extract should be well confirmed in animal models and clinical trials.

Preparation and evaluation of ovalbumin-fucoidan nanoparticles for nicotinamide mononucleotide encapsulation with enhanced stability and anti-aging activity

Nicotinamide mononucleotide (NMN) has been recognized as a promising bio-active compound in relieving aging-related mitochondrial dysfunction. Self-assembled nanoparticles were prepared based on interaction between ovalbumin (OVA) and fucoidan to improve the stability and bio-accessibility of NMN. The OVA-fucoidan nanoparticles (OFNPs) displayed outstanding thermal stability and entrapment ability of NMN. The reactive oxygen species (ROS) analysis and senescence-associated β-galactosidase (SA-β-gal) staining characterization indicated that NMN encapsulated by OFNPs could effectively alleviate the cellular senescence of d-galactose-induced senescent cells. In vivo Caenorhabitis elegans experiment demonstrated that NMN-loaded OFNPs caused less accumulation of lipofuscin and protected NMN from thermal damage. Compared with free NMN, the NMN-loaded OFNPs prolonged lifespan from 28 to 31 days, increased 26% reproductive ability, and improved 12% body length of Caenorhabitis elegans. The results indicated that the use of nanocarriers could be a good strategy to improve anti-oxidative stress and anti-aging ability of NMN.

Anti-Oxidative and Anti-Aging Effects of Probiotic Fermented Ginseng by Modulating Gut Microbiota and Metabolites in Caenorhabditis elegans.

Antioxidative and antiaging abilities of probiotic fermented ginseng (PG) were evaluated in Caenorhabditis elegans (C. elegans). Lifespan and effect on heat stress and acute oxidative stress in C. elegans were significantly enhanced by PG. Antioxidative enzymes such as T-SOD, GSH-PX, CAT were significantly up-regulated, and MDA, ROS and apoptosis levels were significantly down-regulated. At the same time, PG exerted antioxidant and anti-aging activities by reducing the expression of DAF-2 mRNA and increasing the expression of SKN-1 and SOD-3 mRNA in C. elegans. In addition, the mechanism of antioxidative and antiaging activities of PG was explored through gut microbiota sequencing and untargeted metabolomics. The results of gut microbiota indicated that PG could significantly improve the composition and structure of microbes in the gut of C. elegans, and the relative abundance of beneficial bacteria was up-regulated. Untargeted metabolomic results elucidated that PG modulated antioxidant and antiaging activities through neuroactive ligand-receptor interaction, Citrate cycle (TCA cycle), pyruvate metabolism, ascorbate and aldarate metabolism and D-Arginine and D-ornithine metabolism of C. elegans. These results indicated that PG had excellent antioxidant and anti-aging activities, providing research value for the development of functional foods and improvement of aging-related diseases.

The Major Stilbene Compound Accumulated in the Roots of a Resistant Variety of Phoenix dactylifera L. Activates Proteasome for a Path in Anti-Aging Strategy

The main objective of the present study is to estimate, through differential analysis, various biological activities of total phenolics content in alcoholic extracts of three date palm varieties sensitive or resistant to Fusarium oxysporum. sp Albidinis. Here, stilbene products with antioxidant and bioactive capacities were evidenced in resistant variety Taabdount (TAAR). Furthermore, the methanolic fraction of the TAAR-resistant date palm variety contains a significant product, determined by LC-MS/MS and 1H, 13C NMR, belonging to the family of hydroxystilbenes, which exhibits antioxidant capacities, inhibits the mushroom tyrosinase activity, and activates and exerts a protective effect on hypochlorite-induced damage in 20S proteasome of human dermal fibroblast aged cells. Altogether, the present results indicate that hydroxystilbene present in resistant Phoenix dactylifera L. should be studied to understand the way that the stilbene could exert anti-aging ability.

Physicochemical properties and biological activities of Tremella hydrocolloids

In this paper, the physicochemical properties, antioxidant and anti-aging abilities of three new Tremella hydrocolloids were studied. The physicochemical properties were characterized by Fourier transform infrared spectroscopy, differential scanning calorimeter, X-ray diffractometry etc. The antioxidant activities of Tremella hydrocolloids were determined by ABTS radical, DPPH radical scavenging activity. The anti-aging ability of Tremella hydrocolloids was also investigated by using the organism model of Caenorhabditis elegans (C. elegans). The results showed that the ES-THD displayed the highest radical scavenging capacity and the best anti-aging abilities. The ability of ES-THD to scavenge ABTS radicals reached 100 % at 2 mg/mL, the ability of ES-THD to scavenge DPPH radicals reached 45.55 %. Compared with the control group, the average lifespan was 29.17 % longer fed with ES-THD. These results provide the evidence basis for the use of Tremella hydrocolloids as food texture modifiers, antioxidants, and anti-aging agents in the food industries.

Rheological Properties and Microstructural Analysis of Asphalt Binder Doped with Anti-Stripping Agent after Aging

In order to comprehensively explore the long-term durability of asphalt mixed with an anti-stripping agent, laboratory tests were carried out on base asphalt, SBS modified asphalt and base asphalt mixed with an anti-stripping agent after long-term aging. The rheological properties, chemical composition and microscopic morphology of the three asphalts before and after aging were compared and analyzed from macroscopic and microscopic angles. The results show that the modulus of asphalt is more affected by temperature than aging, and the anti-aging ability of the asphalt with the anti-stripping agent is better than that of base asphalt and slightly worse than that of SBS modified asphalt. The change in the absorption peak intensity before and after the aging of asphalt with the anti-stripping agent is the same as those of the base asphalt and SBS modified asphalt at 2920 cm−1 and 2850 cm−1, while the opposite pattern is observed in other four places. The honeycomb structures of the base asphalt and SBS modified asphalt became longer and the number of peaks increased slightly after aging. However, the asphalt surface with the anti-stripping agent had no obvious honeycomb structures before aging, and there were obvious honeycomb structures after aging, the number of which was between those of the base asphalt and SBS modified asphalt after aging; moreover, the lengths of honeycomb structures were still significantly smaller than those of the base asphalt after aging. This study investigated the performance changes of the anti-stripping-agent asphalt before and after long-term aging at multiple scales and compared the asphalt mixed with the anti-stripping agent with base asphalt and SBS modified asphalt to fully evaluate its long-term durability.

Effect of reactive flexible rejuvenators on thermal-oxidative aging resistance of regenerated SBS modified asphalt

The high-quality regeneration of aged SBS modified asphalt could promote to achieve the objective of low-carbon development. In this study, to reconstruct the structure of aged SBS, two kinds of reactive flexible rejuvenator (RFRs) named T-PEG and T-HTPB were synthesized from 2,4-toluylene di-isocyanate, polyethylene glycol and hydroxyl terminated polybutadiene. The ordinary regenerated SBS modified asphalt (RSBSMA) and reactive RSBSMA were prepared by using aromatic hydrocarbon oil (AO) and (T-PEG/T-HTPB + AO) respectively. Afterward, the chemical structures and physio-rheological performance of RSBSMAs after short-term and long-term thermal-oxidative aging were explored. The results of Fourier transform infrared spectra showed that the butadiene and ether bond indices of reactive RSBSMA decreased significantly after aging, indicating that T-HTPB regenerated SBS mainly suffered the breaking of carbon-carbon double bonds, while the degradation of segments with ether bonds appeared in SBS restored by T-PEG. The carbonyl and sulfoxide indices of reactive RSBSMA were lower than those of ordinary RSBSMA, revealing that the effect of thermal-oxidative aging on asphalt was prevented by the restoration of aged SBS structure. The changing amplitude of physical and rheological properties of reactive RSBSMA after aging was less than that of ordinary RSBSMA, which confirmed that the aging resistance of reactive RSBSMA was stronger than that of ordinary RSBSMA due to the repair of aged SBS structure. Different RFRs could offer diverse anti-aging abilities on reactive RSBSMA. The research results suggested that T-PEG rather than T-HTPB was a better choice as a reactive rejuvenator of aged SBS modified asphalt.

Anti-Aging Effects of R-Phycocyanin from Porphyra haitanensis on HUVEC Cells and Drosophila melanogaster.

Aging has become a global public health challenge. Many studies have revealed that the excessive generation of ROS and oxidative stress could be the major causative factors contributing to aging. In this study, R-phycocyanin (R-PC) was isolated from Porphyra haitanensis, and its anti-aging ability was explored by natural aging Drosophila melanogaster and H2O2-induced HUVEC cells as the aging model. Results showed that R-PC α and β subunits expressed have antioxidant activity and can inhibit the generation of radicals, exhibiting a protective effect against H2O2-induced apoptotic HUVEC cells death. R-PC prevented the H2O2-induced HUVEC cell cycle phase arrest by regulating cell cycle-related protein. Furthermore, R-PC prevented the H2O2-induced HUVEC cell cycle phase arrest by regulating cell-cycle-related protein expression. In vivo study also indicated that R-PC significantly increased the survival time and alleviated the oxidative stress of Drosophila melanogaster. Moreover, R-PC notably decreased levels of ROS in natural aging flies and inhibited lipid peroxidation by enhancing the expressions of the endogenous stress marker genes (SOD1, SOD2, CAT of Drosophila melanogaster). Taken together, a study on the antioxidation extract from Porphyra haitanensis, such as R-PC, may open a new window for the prevention of anti-aging.

Preparation and properties of a novel high-viscosity modified bitumen

To develop a high-performance binder for open-graded porous asphalt mixtures, a novel high-viscosity modified bitumen (N-HVA) was prepared by melt blending base bitumen, terpene-styrene resin (TSR), styrene–butadienestyrene block copolymer (SBS), compatibilizer, and stabilizer, the optimal dosage of each modifier was determined. Properties and microstructure of the N-HVA were explored. Two commercially high-viscosity modified bitumens, TPS-HVA and SINOTPS-HVA, were adopted for comparison. The test results show that the appropriate dosage of modifiers is 7 wt% SBS, 4 wt% TSR, 3 wt% compatibilizer, and 0.2 wt% stabilizer. N-HVA shows improved rutting resistance, anti-aging ability, low-temperature flexibility, and meets the storage stability requirements. It demonstrated a more balanced performance than SINOTPS-HVA and TPS-HVA. During the preparation of N-HVA, the addition of the modifier inhibits the phase transition of the bitumen and raises the thermal stability of the composite system. In addition, the composite modifier possesses excellent compatibility with the base bitumen. The modification process is mainly based on physical blending, accompanied by chemical reactions..

Chlorogenic Acid Prevents UVA-Induced Skin Photoaging through Regulating Collagen Metabolism and Apoptosis in Human Dermal Fibroblasts.

Skin aging is categorized as chronological aging and photo-aging that affected by intrinsic and extrinsic factors. The present study aimed to investigate the anti-aging ability and its underlying mechanism of chlorogenic acid (CGA) on human dermal fibroblasts (HDFs). In this study, CGA specifically up-regulated collagen I (Col1) mRNA and protein expressions and increased the collagen secretion in the supernatant of HDFs without affecting the cell viability, the latter was also demonstrated in BioMAP HDF3CGF system. Under ultraviolet A (UVA)-induced photoaging, CGA regulated collagen metabolism by increasing Col1 expression and decreasing matrix metalloproteinase 1 (MMP1) and MMP3 levels in UVA-irradiated HDFs. The activation of transforming growth factor-β (TGF-β)-mediated Smad2/3 molecules, which is crucial in Col1 synthesis, was suppressed by UVA irradiation and but enhanced at the presence of CGA. In addition, CGA reduced the accumulation of UVA-induced reactive oxygen species (ROS), attenuated the DNA damage and promoted cell repair, resulting in reducing the apoptosis of UVA-irradiated HDFs. In conclusion, our study, for the first time, demonstrate that CGA has protective effects during skin photoaging, especially triggered by UVA-irradiation, and provide rationales for further investigation of CGA being used to prevent or treat skin aging.

Impacts of shell structure on nitrate-reduction activity and air stability of nanoscale zero-valent iron.

Nanoscale zero-valent iron (nZVI) has been intensively studied for pollution control because of its high reductive activity and environmental benignity, but the poor reaction selectivity and the aging problem have limited its practical decontamination application. Here, we shed light on the impacts of nZVI shell structure on its reactivity and air stability by systematically comparing two nZVI materials with distinct iron oxide shells. The nZVI with highly crystalline and weakly hydrophilic shell exhibited ninefold higher intrinsic activity for nitrate reduction and significantly improved air stability than that with amorphous, hydrophilic iron hydroxide oxide shell. The compact-structured crystalline shell of nZVI facilitated more efficient interfacial electronic transfer for nitrate reduction and suppressed side reaction of hydrogen evolution. The protective hematite shell endowed the nZVI with significantly improved anti-aging ability, and the reducing force remained 92.6% after exposed to air for 10days due to decreased oxygen diffusion. This work provides a better understanding of the pollutant degradation behavior of nZVI and may guide an improved synthesis and environmental application of nZVI.

Arbuscular mycorrhizal colonization increases plant above-belowground feedback in a northwest Chinese coal mining-degraded soil by increasing photosynthetic carbon assimilation and allocation to maize.

A three-compartment culture system was used to study the mechanism by which the AM fungus Funneliformis mosseae influences host plant growth and soil organic carbon (SOC) content in a northwest China coal mining area. A 13CO2 pulse tracing technique was used to trace the allocation of maize photosynthetic C in shoots, roots, AM fungus, and soil. Carbon accumulation and allocation in mycorrhizal (inoculated with Funneliformis mosseae) and non-mycorrhizal treatments were detected. AM fungal inoculation significantly increased the 13C concentration and content in both above- and below-ground plant parts and also significantly enhanced anti-aging ability by increasing soluble sugars and catalase activity (CAT) in maize leaves while reducing foliar malondialdehyde content (MDA) and leaf temperature and promoted plant growth. AM fungi also increased P uptake to promote maize growth. Soil organic carbon (SOC), glomalin, microbial biomass carbon (MBC), and nitrogen (MBN) contents increased significantly after inoculation. A mutually beneficial system was established involving maize, the AM fungus and the microbiome, and the AM fungus became an important regulator of C flux between the above- and below-ground parts of the system. Inoculation with the AM fungus promoted plant growth, C fixation and allocation belowground to enhance soil quality. A positive above-belowground feedback appeared to be established.

The synergistic effect of Angelica sinensis (Oliv.) Diels and Rehmannia glutinosa (Gaertn.) DC. on antioxidant activity and protective ability against cell injury.

Oxidative stress-induced dysfunction of nerve cells has been implicated as a crucial cause of cell death in neurodegenerative diseases. In Asian countries, herbs, such as Angelica sinensis (Oliv.) Diels (DG) and Rehmannia glutinosa (Gaertn.) DC. (SDH), have long be considered to have antiaging abilities. The herbs act as neuro protectants that rescue nerve cells from oxidative stress damage and apoptosis. Thus, developing herbal formulas can potentially lead to new treatments for neurodegenerative diseases. In this study, we compared the effective active components and antioxidant properties of extractive of DG and SDH (DG-SDH) when formulated at different ratios. DG-SDH formulated at a ratio of 3:2 (DG-SDH [3:2]) produced the highest content of polysaccharides, polyphenols, and flavonoids. It also showed the best ability in removing DPPH and hydroxyl free radicals compared to single herb or other compounding ratio. The antioxidant activity of DG-SDH (3:2) showed best synergistic effects in scavenging activity assays of DPPH free radicals and hydroxyl free radicals. DG-SDH (3:2) could increase the cell viability of SHSY-5Y cells, PC-12 cells, and BV-2 cells. In particular, DG-SDH (3:2) protected SHSY-5Y cells from H2 O2 -induced cell injury by inhibiting excessive expression of reactive oxygen species (ROS), reducing the rate of apoptosis and restoring mitochondrial membrane potential. Actin-Tracker Green and DAPI staining and fluorescence microscope observation confirmed that DG-SDH (3:2) helped in preserving cell morphology under oxidative stress. These findings support that DG-SDH (3:2) promote the neuroprotection against hydrogen peroxide and can serve as a novel therapy for neurodegenerative diseases. PRACTICAL APPLICATIONS: This is the first study to investigate DG and SDH interaction between effective ingredients. These findings support that DG-SDH (3:2) has the best synergistic effects in antioxidant activity and promote the neuroprotection against hydrogen peroxide. Hence, DG-SDH (3:2) will be an excellent candidate to be developed as a functional food ingredients or nutraceuticals for neurodegenerative diseases.

Feasibility assessment of CeO2 nanoparticles as aging-resistant agent of asphalt

Asphalt aging seriously decreases the pavement performances and service life of asphalt pavement. Previous studies have indicated that CeO2 nanoparticles reveal ultraviolet light absorption characteristics. While the function mechanism of CeO2 nanoparticles to asphalt is still not clear. To further enrich the types of aging-resistant agent and extend the service life of asphalt, the influence of CeO2 nanoparticles on the aging resistance of asphalt was explored in this paper. The optical characteristics of CeO2 nanoparticles crystal and layered double hydroxides (LDHs) crystal were analyzed by ultraviolet visible spectrophotometer. CeO2 nanoparticles modified asphalt and LDHs-modified asphalt were prepared and phase segregation tests were performed to evaluate the compatibility of modified asphalt. Subsequently, brookfield viscometer and dynamic shear rheometer (DSR) were conducted to evaluate the viscosity and rheological properties of virgin asphalt, CeO2 nanoparticles modified asphalt and LDHs modified asphalt before and after thin film oven test (TFOT), pressure aging vessel (PAV) and ultraviolet (UV) aging. And their functional group characteristics and micromorphology were investigated through fourier transform infrared spectrometer (FTIR) and atomic force microscope (AFM). The results show that CeO2 nanoparticles mainly absorb ultraviolet light, while LDHs mainly reflects ultraviolet light. The storage stability of CeO2 nanoparticles modified asphalt is slightly lower than that of LDHs modified asphalt, but the storage stability of the two modified asphalt met the specification requirements. Incorporating CeO2 nanoparticles to asphalt can augment the viscosity and complex modulus of asphalt and strengthen its anti-aging ability, especially for anti-ultraviolet aging. There is not new absorption peak on the infrared spectrum of CeO2 nanoparticles modified asphalt binder after the modification, which illustrates that modification of CeO2 into asphalt is considered to be a physical process. Moreover, LDHs modified asphalt demonstrates superior anti-aging effect than that of CeO2 nanoparticles modified asphalt. Overall, CeO2 nanoparticles can also be used as an aging-resistant agent of asphalt.

Research on Performance of SBS-PPA and SBR-PPA Compound Modified Asphalts.

Although several studies indicated that the addition of Styrene-Butadiene-Styrene (SBS) and Styrene-Butadiene Rubber (SBR) bring a lot of benefits on properties of asphalt binders, high production costs and poor storage stability confine the manufacture of better modified asphalt. To reduce the production costs, polyphosphoric acid (PPA) was applied to prepare better compound modified asphalt binders. In this research, five PPA (0.5%, 0.75%, 1.0%, 1.25% and 1.5%) and two SBR/SBS (4% and 6%) concentrations were selected. Dynamic shear rheometer (DSR) and Bending Beam Rheometer (BBR) tests were performed to evaluate the rheological properties of the compound modified asphalt. Rolling Thin Film Oven (RTFO) test was performed to evaluate the aging properties of the compound modified asphalts. The results indicate that SBS/SBR modified asphalts with the addition of PPA show better high-temperature properties significantly, the ability of asphalt to resist rutting is improved, and the elastic recovery is increased. However, the low-temperature properties of the compound modified asphalts are degraded by increasing the creep stiffness (S) and decreasing the creep rate (m). At the same time, RTFO tests results show that PPA was less prone to oxidation to improve the anti-aging ability of modified asphalts. Overall, the combination of 4% SBS and 0.75–1.0% PPA, the combination of 4% SBR and 0.5–0.75% PPA is recommended based on a comprehensive analysis of the performance of compound modified asphalt, respectively, which can be equivalent to 6% SBS/SBR modified asphalt with high-temperature properties, low-temperature properties, temperature sensitivity and aging properties.

Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age.

Alzheimer’s and Parkinson’s diseases are the two most common forms of neurodegenerative diseases. The exact etiology of these disorders is not well known; however, environmental, molecular, and genetic influences play a major role in the pathogenesis of these diseases. Using Alzheimer’s disease (AD) as the archetype, the pathological findings include the aggregation of Amyloid Beta (Aβ) peptides, mitochondrial dysfunction, synaptic degradation caused by inflammation, elevated reactive oxygen species (ROS), and cerebrovascular dysregulation. This review highlights the neuroinflammatory and neuroprotective role of epigallocatechin-3-gallate (EGCG): the medicinal component of green tea, a known nutraceutical that has shown promise in modulating AD progression due to its antioxidant, anti-inflammatory, and anti-aging abilities. This report also re-examines the current literature and provides innovative approaches for EGCG to be used as a preventive measure to alleviate AD and other neurodegenerative disorders.

The Composition and Anti-Aging Activities of Polyphenol Extract from Phyllanthus emblica L. Fruit.

Phyllanthus emblica L. (PE) is commonly known as a medicine and food homologous plant, which is abundant in natural products polyphenols. In the present study, polyphenols were extracted from PE fruit by response surface method, and the anti-aging ability was determined. PE fruit polyphenols exhibited strong antioxidant capacities in scavenging free radicals, and anti-cholinesterase ability by inhibition of AChE (IC50 0.2186 ± 0.0416 mg/mL) and BuChE (IC50 0.0542 ± 0.0054 mg/mL) in vitro. Moreover, PE fruit polyphenols showed strong protective effect against the aging process in Caenorhabditis elegans model, including increased thermal resistance, extended lifespan by 18.53% (p < 0.05), reduced activity of AChE by 34.71% and BuChE by 45.38% (p < 0.01). This was accompanied by the enhancement in antioxidant enzymes activity of SOD by 30.74% (p < 0.05) and CAT by 8.42% (p > 0.05), while decrease in MDA level by 36.25% (p < 0.05). These properties might be interrelated with the presence of abundant flavonols and phenolic acids identified by UPLC-ESI-QTOF-MS, such as quercetin, myricetin, ellagic, gallic, and chlorogenic acids, together with their glycosides. The remarkable antioxidant and anti-aging potential of PE fruit polyphenols could be implemented in the food and pharmaceutical industry.