Objective: Survivors of childhood cancer have increased cardiovascular (CV) morbidity and mortality possibly related to anticancer treatment. Therefore, we assessed CV risk profile and arterial function in the young adults with acute lymphoblastic leukemia (ALL) in whom chemotherapy was completed at least five years ago. Methods: Young (age: 18–30 years) survivors of ALL were invited for assessment of CV risk factors and arterial function. Medical history, physical examination with anthropological measurements, ambulatory blood pressure monitoring; levels of fasting glucose (FG), cholesterol, fibrinogen, hsCRP were measured. Arterial function was assessed using endothelium dependent flow-mediated dilatation (FMD%) of right brachial artery and carotid -femoral pulse wave velocity (PWV). Results: We present preliminary results of 14 subjects (7 men, age: 21,4 ± 3,08) years) who agreed to participate in the study. Mean BMI was 22(2,01) and WHR 0,79(0,06). 24-hour mean BP was 116,8(7,2)/68,3(4,7) mmHg. The values of laboratory findings were: FG: 4,6(0,3) mmol/l, hsCRP: 0,83(1,2) mg/l, TC: 4,28(0,8) mmol/l, LDL: 2,28(0,7) mmol/l, HDL: 1,57(0,4) mmol/l, TG: 0,97(0,48) mmol/l, fibrinogen: 3,1(0,5) g/l. Five subjects presented with 1 or more CV risk factors such as smoking (4), positive family history of CVD (2), hypercholesterolemia (2), masked hypertension (1). Patients had a mean basal brachial artery diameter of 3,40 ± 0,67 mm. Mean FMD response was 5,74 ± 5,99 % and reactive hyperemia: 51,66 ± 28,25%, the percent change in nitrogliceryne mediated dilatation was 23,36 ± 10,12%. 9 (64%) participants had FMD < 10% and 7 < 7%. When 9 subjects without CV risk factors were analysed in 6 of them FMD was found to be below 10% and in 5 < 7%. Mean PWV was 8,03(0,81) m/s and in 9 subjects exceeded 8 m/s. Moreover, PWV was increased in 4 out of 9 subjects without CV risk factors. Conclusions: These preliminary results indicate that even in the absence of major cardiovascular risk factors young adult survivors of ALL demonstrate impaired endothelial function and increased arterial stiffness.