Aim of the workto report our personal experience on hindfoot reconstruction by means of anterolateral thigh (ALT) flap after radical resection of a high-grade synovial sarcoma. Methodspatient underwent clinical and instrumental assessments, and a biopsy of the lesion confirmed the diagnosis of synovial sarcoma of the hindfoot. A multidisciplinary team was required to decide the better therapeutic strategy. ResultsAfter radical tumor mass resection, the coverage of the large skin gap was achieved with an ALT flap. No recurrences were observed during the follow-up. Today, after eighteen months after surgical treatment, the patient can walk independently with no major limitations in everyday life. Conclusionsthe complex management of this rare disease requires the presence of a reference center for foot and ankle surgery, and a multidisciplinary team including expert orthopedics and plastic surgeons, as well as oncologists, to ensure an optimal and correct treatment of the disease.